十五氟辛酸（CAS 335-67-1）：分子式 C8HF15O2、分子量 414.07。
| CAS号 | 335-67-1 |
|---|---|
| 分子式 | C8HF15O2 |
| 分子量 | 414.07 |
| 熔点 | 54.3 °C |
| 沸点 | 192 °C |
| LogP | 4.9 |
| 应用领域 | Uses: Used to produce fire-fighting applications、cosmetics、greases、lubricants、paints、polishes、and adhesives、[HSDB]、. . . major US manufacturers of AFFF [aqueous film-forming foam] indicated they would no longer produce PFOA-based fluorosurfactant foams after 2015. [PMID 31045850]、In fire-fighting applications、greases and lubricants、polishes and adhesives、Fluorinated surfactants、Long-chain perfluoroalkanecarboxylic acids and their salts are surface-active chemicals (surfactants)、which greatly reduce the surface tension (surface energy) of water、aqueous solutions、and organic liquids even at low concentrations. These acids (C6- C12) and derivatives are used as wetting、dispersing、emulsifying、and foaming agents.、Long-chain perfluoroalkanecarboxylic acids、non-polymer PFAS -> Personal Care products and cosmetics -> Sunscreen、non-polymer PFAS -> Laboratory Supplies -> Impregnation spray for leather and textile、non-polymer PFAS -> Pesticides -> General、non-polymer PFAS -> Cook and Bakingware -> Baking ware、non-polymer PFAS -> Medicinal Utensils -> Dental floss、non-polymer PFAS -> Textile and upholstery -> Impregnation spray for textiles、non-polymer PFAS -> Floor coverings -> Carpets in general、non-polymer PFAS -> Laboratory Supplies -> Polish for leather、including leather of shoes、non-polymer PFAS -> Personal Care products and cosmetics -> Cosmetics and personal care products in general、non-polymer PFAS -> Personal Care products and cosmetics -> Eye cream、eye shadow、non-polymer PFAS -> Floor coverings -> Nylon carpets、non-polymer PFAS -> Wood processing -> Wood building materials、non-polymer PFAS -> Sports articles -> (Sailing) boat equipment - textiles for maritime applications、non-polymer PFAS -> Coatings、Paints and Varnishes -> Paints in general、non-polymer PFAS -> Personal Care products and cosmetics -> Manicure product、non-polymer PFAS -> Oil and Gas Industry -> Chemical driven oil production、non-polymer PFAS -> Photographic Industry -> Photographic material、non-polymer PFAS -> Fire-Fighting Foam -> Aqueous film-forming foams (AFFF)、non-polymer PFAS -> Sealants and adhesives -> Sealants、non-polymer PFAS -> Automotive -> Automotive waxes and polish、Paints and Varnishes -> Coatings in general、non-polymer PFAS -> Personal Care products and cosmetics -> Lip balm、lip stick、lip gloss、non-polymer PFAS -> Personal Care products and cosmetics -> Body lotion、body cream、body oil、non-polymer PFAS -> Personal Care products and cosmetics -> Concealer、corrector、non-polymer PFAS -> Apparel -> Apparel、non-polymer PFAS -> Cleaning compositions -> Cleaning compositions for dishes and glasses、non-polymer PFAS -> Laboratory Supplies -> Impregnation of genuine leather、non-polymer PFAS -> Building and Construction -> Greenhouse、non-polymer PFAS -> Floor coverings -> Floor polish、non-polymer PFAS -> Sports articles -> Bicycle lubricant、non-polymer PFAS -> Paper and packaging -> Food-contact articles、non-polymer PFAS -> Electronic Industry -> Pulsed plasma nano-coating to manufacture smartphone、non-polymer PFAS -> Personal Care products and cosmetics -> Highlighter、non-polymer PFAS -> Personal Care products and cosmetics -> BB、CC cream、foundation、non-polymer PFAS -> Textile and upholstery -> Textile and upholstery、non-polymer PFAS -> Automotive -> General use、non-polymer PFAS -> Sports articles -> Ski wax、It has been used in the manufacture of such prominent consumer goods as Teflon and Gore-Tex. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion range、and levels are higher in chemical plant employees and surrounding subpopulations. Exposure has been associated with increased cholesterol and uric acid levels、and recently higher serum levels of PFOA were found to be associated with increased risk of chronic kidney disease in the general United States population、consistent with earlier animal studies. This association was independent of confounders such as age、sex、race、ethnicity、body mass index、diabetes、hypertension、and serum cholesterol level.、Use Classification: Food Contaminant -> CONTAMINANT、Food Contaminant -> -> JECFA Functional Classes、PFAS -> PFcarboxylic acids (PFCA)、PFAS (per- and polyfluoroalkyl substances) -> OECD Category、PFAS、Household Products: Information on 1 consumer products that contain Perfluorooctanoic acid in the following categories is provided:、• Commercial、Institutional、Methods of Manufacturing: PFOA can be commercially manufactured by two major alternative processes: The Simons Electro-Chemical Fluorination (ECF) process、and a telomerization process. ... In the ECF process、an electric current is passed through a solution of anhydrous hydrogen fluoride and an organic feedstock of octanoic acid or a derivative. The ECF process replaces the carbon-hydrogen bonds on molecules of the organic feedstock with carbon-fluorine bonds. Perfluorination occurs when all the carbon-hydrogen bonds are replaced with carbon-fluorine ones. The ECF process yields between 30-45% straight chain (normal) perfluorooctanonyl fluoride (PFOF)、along with a variable mixture of byproducts and impurities. The output of the ECF process consists of a complex combination of chemical substances with varying molecular weights、including higher and lower straight-chain homologues、branched-chain perfluoroalkyl fluorides of various chain lengths、straight-chain、branched、and cyclic perfluoroalkanes and ethers、and other byproducts. After disposal or recovery of some of the byproducts and impurities、the acid fluoride is base hydrolyzed in batch reactors to yield PFOA. The PFOA salts are synthesized by base neutralization of the acid to the salt in a separate reactor. In the telomerization process、tetrafluoroethylene is reacted with other fluorine-bearing chemicals to yield fluorinated intermediates which are readily converted |
登记用途：Uses: Used to produce fire-fighting applications、cosmetics、greases、lubricants、paints、polishes、and adhesives、[HSDB]、. . . major US manufacturers of AFFF [aqueous film-forming foam] indicated they would no longer produce PFOA-based fluorosurfactant foams after 2015. [PMID 31045850]、In fire-fighting applications、greases and lubricants、polishes and adhesives、Fluorinated surfactants、Long-chain perfluoroalkanecarboxylic acids and their salts are surface-active chemicals (surfactants)、which greatly reduce the surface tension (surface energy) of water、aqueous solutions、and organic liquids even at low concentrations. These acids (C6- C12) and derivatives are used as wetting、dispersing、emulsifying、and foaming agents.、Long-chain perfluoroalkanecarboxylic acids、non-polymer PFAS -> Personal Care products and cosmetics -> Sunscreen、non-polymer PFAS -> Laboratory Supplies -> Impregnation spray for leather and textile、non-polymer PFAS -> Pesticides -> General、non-polymer PFAS -> Cook and Bakingware -> Baking ware、non-polymer PFAS -> Medicinal Utensils -> Dental floss、non-polymer PFAS -> Textile and upholstery -> Impregnation spray for textiles、non-polymer PFAS -> Floor coverings -> Carpets in general、non-polymer PFAS -> Laboratory Supplies -> Polish for leather、including leather of shoes、non-polymer PFAS -> Personal Care products and cosmetics -> Cosmetics and personal care products in general、non-polymer PFAS -> Personal Care products and cosmetics -> Eye cream、eye shadow、non-polymer PFAS -> Floor coverings -> Nylon carpets、non-polymer PFAS -> Wood processing -> Wood building materials、non-polymer PFAS -> Sports articles -> (Sailing) boat equipment - textiles for maritime applications、non-polymer PFAS -> Coatings、Paints and Varnishes -> Paints in general、non-polymer PFAS -> Personal Care products and cosmetics -> Manicure product、non-polymer PFAS -> Oil and Gas Industry -> Chemical driven oil production、non-polymer PFAS -> Photographic Industry -> Photographic material、non-polymer PFAS -> Fire-Fighting Foam -> Aqueous film-forming foams (AFFF)、non-polymer PFAS -> Sealants and adhesives -> Sealants、non-polymer PFAS -> Automotive -> Automotive waxes and polish、Paints and Varnishes -> Coatings in general、non-polymer PFAS -> Personal Care products and cosmetics -> Lip balm、lip stick、lip gloss、non-polymer PFAS -> Personal Care products and cosmetics -> Body lotion、body cream、body oil、non-polymer PFAS -> Personal Care products and cosmetics -> Concealer、corrector、non-polymer PFAS -> Apparel -> Apparel、non-polymer PFAS -> Cleaning compositions -> Cleaning compositions for dishes and glasses、non-polymer PFAS -> Laboratory Supplies -> Impregnation of genuine leather、non-polymer PFAS -> Building and Construction -> Greenhouse、non-polymer PFAS -> Floor coverings -> Floor polish、non-polymer PFAS -> Sports articles -> Bicycle lubricant、non-polymer PFAS -> Paper and packaging -> Food-contact articles、non-polymer PFAS -> Electronic Industry -> Pulsed plasma nano-coating to manufacture smartphone、non-polymer PFAS -> Personal Care products and cosmetics -> Highlighter、non-polymer PFAS -> Personal Care products and cosmetics -> BB、CC cream、foundation、non-polymer PFAS -> Textile and upholstery -> Textile and upholstery、non-polymer PFAS -> Automotive -> General use、non-polymer PFAS -> Sports articles -> Ski wax、It has been used in the manufacture of such prominent consumer goods as Teflon and Gore-Tex. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion range、and levels are higher in chemical plant employees and surrounding subpopulations. Exposure has been associated with increased cholesterol and uric acid levels、and recently higher serum levels of PFOA were found to be associated with increased risk of chronic kidney disease in the general United States population、consistent with earlier animal studies. This association was independent of confounders such as age、sex、race、ethnicity、body mass index、diabetes、hypertension、and serum cholesterol level.、Use Classification: Food Contaminant -> CONTAMINANT、Food Contaminant -> -> JECFA Functional Classes、PFAS -> PFcarboxylic acids (PFCA)、PFAS (per- and polyfluoroalkyl substances) -> OECD Category、PFAS、Household Products: Information on 1 consumer products that contain Perfluorooctanoic acid in the following categories is provided:、• Commercial、Institutional、Methods of Manufacturing: PFOA can be commercially manufactured by two major alternative processes: The Simons Electro-Chemical Fluorination (ECF) process、and a telomerization process. ... In the ECF process、an electric current is passed through a solution of anhydrous hydrogen fluoride and an organic feedstock of octanoic acid or a derivative. The ECF process replaces the carbon-hydrogen bonds on molecules of the organic feedstock with carbon-fluorine bonds. Perfluorination occurs when all the carbon-hydrogen bonds are replaced with carbon-fluorine ones. The ECF process yields between 30-45% straight chain (normal) perfluorooctanonyl fluoride (PFOF)、along with a variable mixture of byproducts and impurities. The output of the ECF process consists of a complex combination of chemical substances with varying molecular weights、including higher and lower straight-chain homologues、branched-chain perfluoroalkyl fluorides of various chain lengths、straight-chain、branched、and cyclic perfluoroalkanes and ethers、and other byproducts. After disposal or recovery of some of the byproducts and impurities、the acid fluoride is base hydrolyzed in batch reactors to yield PFOA. The PFOA salts are synthesized by base neutralization of the acid to the salt in a separate reactor. In the telomerization process、tetrafluoroethylene is reacted with other fluorine-bearing chemicals to yield fluorinated intermediates which are readily converted。
十五氟辛酸 是一种化工化合物，登记 CAS 号为 335-67-1，分子式 C8HF15O2（分子量 414.07）。
登记 CAS 号：335-67-1
其分子式 C8HF15O2 由 8 个碳、1 个氢、15 个氟、2 个氧 组成。
别名/同义词：十五氟辛酸 · Pentadecafluorooctanoic acid
十五氟辛酸 的 CAS 登记号为 335-67-1。
分子式 C8HF15O2，分子量 414.07。
别名/同义词：十五氟辛酸、Pentadecafluorooctanoic acid。
登记用途：Uses: Used to produce fire-fighting applications、cosmetics、greases、lubricants、paints、polishes、and adhesives、[HSDB]、. . . major US manufacturers of AFFF [aqueous film-forming foam] indicated they would no longer produce PFOA-based fluorosurfactant foams after 2015. [PMID 31045850]、In fire-fighting applications、greases and lubricants、polishes and adhesives、Fluorinated surfactants、Long-chain perfluoroalkanecarboxylic acids and their salts are surface-active chemicals (surfactants)、which greatly reduce the surface tension (surface energy) of water、aqueous solutions、and organic liquids even at low concentrations. These acids (C6- C12) and derivatives are used as wetting、dispersing、emulsifying、and foaming agents.、Long-chain perfluoroalkanecarboxylic acids、non-polymer PFAS -> Personal Care products and cosmetics -> Sunscreen、non-polymer PFAS -> Laboratory Supplies -> Impregnation spray for leather and textile、non-polymer PFAS -> Pesticides -> General、non-polymer PFAS -> Cook and Bakingware -> Baking ware、non-polymer PFAS -> Medicinal Utensils -> Dental floss、non-polymer PFAS -> Textile and upholstery -> Impregnation spray for textiles、non-polymer PFAS -> Floor coverings -> Carpets in general、non-polymer PFAS -> Laboratory Supplies -> Polish for leather、including leather of shoes、non-polymer PFAS -> Personal Care products and cosmetics -> Cosmetics and personal care products in general、non-polymer PFAS -> Personal Care products and cosmetics -> Eye cream、eye shadow、non-polymer PFAS -> Floor coverings -> Nylon carpets、non-polymer PFAS -> Wood processing -> Wood building materials、non-polymer PFAS -> Sports articles -> (Sailing) boat equipment - textiles for maritime applications、non-polymer PFAS -> Coatings、Paints and Varnishes -> Paints in general、non-polymer PFAS -> Personal Care products and cosmetics -> Manicure product、non-polymer PFAS -> Oil and Gas Industry -> Chemical driven oil production、non-polymer PFAS -> Photographic Industry -> Photographic material、non-polymer PFAS -> Fire-Fighting Foam -> Aqueous film-forming foams (AFFF)、non-polymer PFAS -> Sealants and adhesives -> Sealants、non-polymer PFAS -> Automotive -> Automotive waxes and polish、Paints and Varnishes -> Coatings in general、non-polymer PFAS -> Personal Care products and cosmetics -> Lip balm、lip stick、lip gloss、non-polymer PFAS -> Personal Care products and cosmetics -> Body lotion、body cream、body oil、non-polymer PFAS -> Personal Care products and cosmetics -> Concealer、corrector、non-polymer PFAS -> Apparel -> Apparel、non-polymer PFAS -> Cleaning compositions -> Cleaning compositions for dishes and glasses、non-polymer PFAS -> Laboratory Supplies -> Impregnation of genuine leather、non-polymer PFAS -> Building and Construction -> Greenhouse、non-polymer PFAS -> Floor coverings -> Floor polish、non-polymer PFAS -> Sports articles -> Bicycle lubricant、non-polymer PFAS -> Paper and packaging -> Food-contact articles、non-polymer PFAS -> Electronic Industry -> Pulsed plasma nano-coating to manufacture smartphone、non-polymer PFAS -> Personal Care products and cosmetics -> Highlighter、non-polymer PFAS -> Personal Care products and cosmetics -> BB、CC cream、foundation、non-polymer PFAS -> Textile and upholstery -> Textile and upholstery、non-polymer PFAS -> Automotive -> General use、non-polymer PFAS -> Sports articles -> Ski wax、It has been used in the manufacture of such prominent consumer goods as Teflon and Gore-Tex. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion range、and levels are higher in chemical plant employees and surrounding subpopulations. Exposure has been associated with increased cholesterol and uric acid levels、and recently higher serum levels of PFOA were found to be associated with increased risk of chronic kidney disease in the general United States population、consistent with earlier animal studies. This association was independent of confounders such as age、sex、race、ethnicity、body mass index、diabetes、hypertension、and serum cholesterol level.、Use Classification: Food Contaminant -> CONTAMINANT、Food Contaminant -> -> JECFA Functional Classes、PFAS -> PFcarboxylic acids (PFCA)、PFAS (per- and polyfluoroalkyl substances) -> OECD Category、PFAS、Household Products: Information on 1 consumer products that contain Perfluorooctanoic acid in the following categories is provided:、• Commercial、Institutional、Methods of Manufacturing: PFOA can be commercially manufactured by two major alternative processes: The Simons Electro-Chemical Fluorination (ECF) process、and a telomerization process. ... In the ECF process、an electric current is passed through a solution of anhydrous hydrogen fluoride and an organic feedstock of octanoic acid or a derivative. The ECF process replaces the carbon-hydrogen bonds on molecules of the organic feedstock with carbon-fluorine bonds. Perfluorination occurs when all the carbon-hydrogen bonds are replaced with carbon-fluorine ones. The ECF process yields between 30-45% straight chain (normal) perfluorooctanonyl fluoride (PFOF)、along with a variable mixture of byproducts and impurities. The output of the ECF process consists of a complex combination of chemical substances with varying molecular weights、including higher and lower straight-chain homologues、branched-chain perfluoroalkyl fluorides of various chain lengths、straight-chain、branched、and cyclic perfluoroalkanes and ethers、and other byproducts. After disposal or recovery of some of the byproducts and impurities、the acid fluoride is base hydrolyzed in batch reactors to yield PFOA. The PFOA salts are synthesized by base neutralization of the acid to the salt in a separate reactor. In the telomerization process、tetrafluoroethylene is reacted with other fluorine-bearing chemicals to yield fluorinated intermediates which are readily converted。
十五氟辛酸（CAS 335-67-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 335-67-1 |
|---|---|
| PubChem CID | 9554 |
| Molecular formula | C8HF15O2 |
| IUPAC name | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoic acid |
| UNII (FDA) | 947VD76D3L |
| Molecular Weight | 414.07 |
|---|---|
| XLogP3 | 4.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 17 |
| Rotatable Bond Count | 6 |
| Exact Mass | 413.9737017 |
| Monoisotopic Mass | 413.9737017 |
| Topological Polar Surface Area | 37.3 |
| Heavy Atom Count | 25 |
| Boiling Point | 192 °C |
|---|---|
| Boiling Point | 189 °C |
| Boiling Point | 189 °C @760 [mm Hg] |
| Melting Point | 54.3 °C |
| Melting Point | 52-54 °C |
| Solubility | In water, 3300 mg/L at 25 °C |
| Solubility | In water, 4340 mg/L at 24.1 °C |
| Density | 1.792 g/mL at 20 °C |
| Density | 1.79 g/cm³ |
| Density | 1.792 @ 20°C |
PERFLUOROOCTANOIC ACID; 335-67-1; Pentadecafluorooctanoic acid; PFOA; 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoic acid; Perfluorocaprylic acid; Perfluoroctanoic acid; Perfluoroheptanecarboxylic acid; Perfluoro-n-octanoic acid; Pentadecafluoro-1-octanoic acid; Pentadecafluoro-n-octanoic acid; DTXSID8031865; NSC 95114; AI3-19341; 947VD76D3L; Hexanoyl fluoride, 3,3,4,4,5,5,6,6,6-nonafluoro-2-oxo-
| Regulatory & Food Contact | CONTAMINANT; Food Contaminant ->: Food Contaminant |
|---|
| Reported hazard statements | H302, H318, H332, H351, H362, H372, H314 (31.8%), H360 (68.2%) |
|---|
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
Pentadecafluorooctanoic acid · CAS 335-67-1 · C8HF15O2. UNII 947VD76D3L. Boiling Point: 192 °C; Boiling Point: 189 °C; Boiling Point: 189 °C @760 [mm Hg].
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Pentadecafluorooctanoic acid