吡嘧司特钾

Description

Pemirolast Potassium · CAS 100299-08-9 · C10H8N6O. UNII 2C09NV773M. Melting Point: 310-311 °C (decomposes); Solubility: 4.62e-01 g/L.

Identification

CAS Registry Number	100299-08-9
PubChem CID	57697
Molecular formula	C10H8N6O
IUPAC name	9-methyl-3-(2H-tetrazol-5-yl)pyrido[1,2-a]pyrimidin-4-one
UNII (FDA)	2C09NV773M

Computed Descriptors

Molecular Weight	228.21
XLogP3	-0.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	228.07595890
Monoisotopic Mass	228.07595890
Topological Polar Surface Area	87.1
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	310-311 °C (decomposes)
Solubility	4.62e-01 g/L

Physical description & handling notes

• Solid
• Crystals from dimethylformamide
• In water, 1.9X10+4 mg/L at 25 °C /Estimated/
• 3.3X10-6 mm Hg at 25 °C /Estimated/
• log Kow = 0.36 /Estimated/
• Henry's Law constant = 4.9X10-11 atm-cu m/mole at 25 °C /Estimated/

Documented Uses

• Preparation: P.F. Juby, US 4122274 (1978 to Bristol-Myers)
• Information available in 2004 indicated that Pemirolast potassium was used in the manufacture of pharmaceutical preparations in the following countries: Japan, USA (1,2)
• For the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis
• Breast Feeding; Lactation; Milk, Human; Anti-Allergic Agents; Histamine Antagonists
• Pemirolast ophthalmic solution is indicated for the prophylaxis of itching of the eye associated with allergic conjunctivitis. /Included in US product labeling/ /Pemirolast potassium/
• Headaches, rhinitis, and cold/flu symptoms occurred in 10-25% of patients in clinical trials. ... Ocular burning/stinging, dry eye, foreign body sensation, and ocular discomfort, which occurre in 1-2% of patients, were the most common adverse ocular effects reported in clinical studies. /Pemirolast potassium/

Synonyms

Pemirolast; 69372-19-6; Pemirolastum; Pemirox; Permirolast; 2C09NV773M; 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one; DTXSID1048338; BMY-26517; 4H-Pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-; 9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido(1,2-a)pyrimidin-4-one; 9-methyl-3-(2H-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one; 9-methyl-3-(2H-1,2,3,4-tetrazol-5-yl)-4H-pyrido(1,2-a)pyrimidin-4-one; RefChem:859193; DTXCID6028313; Pemirolast [INN]

Frequently Asked Questions

What are the CAS number and molecular formula of Pemirolast Potassium?

CAS 100299-08-9; molecular formula C10H8N6O; molecular weight — g/mol.

What other names is Pemirolast Potassium known by?

Pemirolast, 69372-19-6, Pemirolastum, Pemirox, Permirolast, 2C09NV773M.

What are the key physical properties of Pemirolast Potassium?

Melting Point: 310-311 °C (decomposes); Solubility: 4.62e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.