对氨基苯甲酸（CAS 150-13-0）：分子式 C7H7NO2、分子量 137.14。
| CAS号 | 150-13-0 |
|---|---|
| 分子式 | C7H7NO2 |
| 分子量 | 137.14 |
| 熔点 | 370 to 372 °F (NTP, 1992) |
| LogP | 0.83 |
| 应用领域 | Uses: Used to make local anesthetics、folic acid、and azo dyes、Also used in feed additives、sunscreens、and medications、[HSDB] Occurs naturally as B complex factor--about 10-100 ppm in brewer's yeast、Farming (Feed Additives) [Category: Industry]、For 4-aminobenzic acid (USEPA、OPP Pesticide Code: 233300) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Manufacture、of、various esters (local anesthetics)、... . Used in laboratories as sulfonamide antagonist.、Dye intermediate、pharmaceuticals、nutrition、UV absorber in suntan lotions.、Used principally in the pharmaceuticals industry、other uses are as a cross-linking agent for polyurethane resins、dyes、and feedstock additives.、MEDICATION、Use (kg、approx.) in Germany (2009): >2500、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Calculated removal (%): 92.1、Use Classification: Cosmetics -> Uv filter、Uv absorber、Methods of Manufacturing: p-Nitrotoluene is oxidized with permanganate to p-nitrobenzoic acid、and the nitro group then is reduced to an amino group with iron and hydrochloric acid.、It is manufactured commercially by the catalytic hydrogenation of 4-nitrobenzoic acid using a platinum or palladium catalyst or by reduction with tin or iron and hydrochloric acid.、The Hofmann degradation reaction of terephthalic acid is ...、a、source of 4-aminobenzoic acid. Dimethyl terephthalate reacts with one equivalent of potassium hydroxide in methanol. The resultant salt is then amidated with liquid ammonia indimethylformamide at 130 - 140 °C to give potassium terephthalamate. This then reacts with sodium hypochlorite solution at 50 - 92 °C. The overall yield is approximately 70%. A two-stage Hofmann reaction has been developed. The yield is 93%.、Formulations、Preparations: Sunscreens are available in a variety of dosage forms and formulations. ... Because these formulations frequently change and the manufacturers often are reluctant to reveal specific ingredients in their formulations、a listing of commercially available sunscreens is not included in this monograph.、Technical、National Formulary、Capsules and tablets (as the potassium salt)、500 mg、Packets (as the potassium salt) 2 g、Powder、U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#6344]、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzoic acid、4-amino-. National Production Volume: Withheld.、General Manufacturing Information: Benzoic acid、4-amino-: ACTIVE、Commercially available as the calcium、potassium、and sodium salts.、p-Aminobenzoic acid is also known as anti-gray hair factor (in rats only).、Absorbs UV light of wavelengths in the region of 260 to 313 nm、its molar absorptivity at 288.5 nm is 18、300. However、it does not absorb throughout the near UV range ... Nevertheless、in the 260 to 313 nm range、it has the highest protection index of current sunscreen agents.、The drug occurs as white or slightly yellow、odorless crystals or crystalline powder. The drug is slightly soluble in water and freely soluble in alcohol. PABA is incompatible with ferric salts and oxidizing agents and darkens on exposure to air or light、preparations of the drug should be stored in light-resistant containers. |
登记用途：Uses: Used to make local anesthetics、folic acid、and azo dyes、Also used in feed additives、sunscreens、and medications、[HSDB] Occurs naturally as B complex factor--about 10-100 ppm in brewer's yeast、Farming (Feed Additives) [Category: Industry]、For 4-aminobenzic acid (USEPA、OPP Pesticide Code: 233300) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Manufacture、of、various esters (local anesthetics)、... . Used in laboratories as sulfonamide antagonist.、Dye intermediate、pharmaceuticals、nutrition、UV absorber in suntan lotions.、Used principally in the pharmaceuticals industry、other uses are as a cross-linking agent for polyurethane resins、dyes、and feedstock additives.、MEDICATION、Use (kg、approx.) in Germany (2009): >2500、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Calculated removal (%): 92.1、Use Classification: Cosmetics -> Uv filter、Uv absorber、Methods of Manufacturing: p-Nitrotoluene is oxidized with permanganate to p-nitrobenzoic acid、and the nitro group then is reduced to an amino group with iron and hydrochloric acid.、It is manufactured commercially by the catalytic hydrogenation of 4-nitrobenzoic acid using a platinum or palladium catalyst or by reduction with tin or iron and hydrochloric acid.、The Hofmann degradation reaction of terephthalic acid is ...、a、source of 4-aminobenzoic acid. Dimethyl terephthalate reacts with one equivalent of potassium hydroxide in methanol. The resultant salt is then amidated with liquid ammonia indimethylformamide at 130 - 140 °C to give potassium terephthalamate. This then reacts with sodium hypochlorite solution at 50 - 92 °C. The overall yield is approximately 70%. A two-stage Hofmann reaction has been developed. The yield is 93%.、Formulations、Preparations: Sunscreens are available in a variety of dosage forms and formulations. ... Because these formulations frequently change and the manufacturers often are reluctant to reveal specific ingredients in their formulations、a listing of commercially available sunscreens is not included in this monograph.、Technical、National Formulary、Capsules and tablets (as the potassium salt)、500 mg、Packets (as the potassium salt) 2 g、Powder、U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#6344]、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzoic acid、4-amino-. National Production Volume: Withheld.、General Manufacturing Information: Benzoic acid、4-amino-: ACTIVE、Commercially available as the calcium、potassium、and sodium salts.、p-Aminobenzoic acid is also known as anti-gray hair factor (in rats only).、Absorbs UV light of wavelengths in the region of 260 to 313 nm、its molar absorptivity at 288.5 nm is 18、300. However、it does not absorb throughout the near UV range ... Nevertheless、in the 260 to 313 nm range、it has the highest protection index of current sunscreen agents.、The drug occurs as white or slightly yellow、odorless crystals or crystalline powder. The drug is slightly soluble in water and freely soluble in alcohol. PABA is incompatible with ferric salts and oxidizing agents and darkens on exposure to air or light、preparations of the drug should be stored in light-resistant containers.。
对氨基苯甲酸 是一种化工化合物，登记 CAS 号为 150-13-0，分子式 C7H7NO2（分子量 137.14）。
登记 CAS 号：150-13-0
其分子式 C7H7NO2 由 7 个碳、7 个氢、1 个氮、2 个氧 组成。
别名/同义词：对氨基苯甲酸 · p-Aminobenzoic acid · 4-Aminobenzoic acid
对氨基苯甲酸 的 CAS 登记号为 150-13-0。
分子式 C7H7NO2，分子量 137.14。
别名/同义词：对氨基苯甲酸、p-Aminobenzoic acid、4-Aminobenzoic acid。
登记用途：Uses: Used to make local anesthetics、folic acid、and azo dyes、Also used in feed additives、sunscreens、and medications、[HSDB] Occurs naturally as B complex factor--about 10-100 ppm in brewer's yeast、Farming (Feed Additives) [Category: Industry]、For 4-aminobenzic acid (USEPA、OPP Pesticide Code: 233300) there are 0 labels match.、SRP: Not registered for current use in the U.S.、but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Manufacture、of、various esters (local anesthetics)、... . Used in laboratories as sulfonamide antagonist.、Dye intermediate、pharmaceuticals、nutrition、UV absorber in suntan lotions.、Used principally in the pharmaceuticals industry、other uses are as a cross-linking agent for polyurethane resins、dyes、and feedstock additives.、MEDICATION、Use (kg、approx.) in Germany (2009): >2500、Consumption (g per capita、approx.) in Germany (2009): 0.0305、Calculated removal (%): 92.1、Use Classification: Cosmetics -> Uv filter、Uv absorber、Methods of Manufacturing: p-Nitrotoluene is oxidized with permanganate to p-nitrobenzoic acid、and the nitro group then is reduced to an amino group with iron and hydrochloric acid.、It is manufactured commercially by the catalytic hydrogenation of 4-nitrobenzoic acid using a platinum or palladium catalyst or by reduction with tin or iron and hydrochloric acid.、The Hofmann degradation reaction of terephthalic acid is ...、a、source of 4-aminobenzoic acid. Dimethyl terephthalate reacts with one equivalent of potassium hydroxide in methanol. The resultant salt is then amidated with liquid ammonia indimethylformamide at 130 - 140 °C to give potassium terephthalamate. This then reacts with sodium hypochlorite solution at 50 - 92 °C. The overall yield is approximately 70%. A two-stage Hofmann reaction has been developed. The yield is 93%.、Formulations、Preparations: Sunscreens are available in a variety of dosage forms and formulations. ... Because these formulations frequently change and the manufacturers often are reluctant to reveal specific ingredients in their formulations、a listing of commercially available sunscreens is not included in this monograph.、Technical、National Formulary、Capsules and tablets (as the potassium salt)、500 mg、Packets (as the potassium salt) 2 g、Powder、U.S. Production: Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#6344]、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzoic acid、4-amino-. National Production Volume: Withheld.、General Manufacturing Information: Benzoic acid、4-amino-: ACTIVE、Commercially available as the calcium、potassium、and sodium salts.、p-Aminobenzoic acid is also known as anti-gray hair factor (in rats only).、Absorbs UV light of wavelengths in the region of 260 to 313 nm、its molar absorptivity at 288.5 nm is 18、300. However、it does not absorb throughout the near UV range ... Nevertheless、in the 260 to 313 nm range、it has the highest protection index of current sunscreen agents.、The drug occurs as white or slightly yellow、odorless crystals or crystalline powder. The drug is slightly soluble in water and freely soluble in alcohol. PABA is incompatible with ferric salts and oxidizing agents and darkens on exposure to air or light、preparations of the drug should be stored in light-resistant containers.。
对氨基苯甲酸（CAS 150-13-0）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 150-13-0 |
|---|---|
| PubChem CID | 978 |
| Molecular formula | C7H7NO2 |
| IUPAC name | 4-aminobenzoic acid |
| UNII (FDA) | TL2TJE8QTX |
| Molecular Weight | 137.14 |
|---|---|
| XLogP3 | 0.8 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 137.047678466 |
| Monoisotopic Mass | 137.047678466 |
| Topological Polar Surface Area | 63.3 |
| Heavy Atom Count | 10 |
| Melting Point | 370 to 372 °F (NTP, 1992) |
|---|---|
| Melting Point | 188.5 |
| Melting Point | 188.5 °C |
| Melting Point | 188 °C |
| Solubility | 6110 |
| Solubility | 6.11 mg/mL |
| Vapor Pressure | 0.000278 [mmHg] |
| LogP | 0.83 |
| LogP | log Kow = 0.83 |
| pH | pH (0.5% solution): 3.5 |
4-aminobenzoic acid; 150-13-0; p-aminobenzoic acid; PABA; Vitamin BX; p-Carboxyaniline; para-aminobenzoic acid; Sunbrella; 4-Carboxyaniline; Paraminol; Pabacyd; Amben; Benzoic acid, 4-amino-; p-Carboxyphenylamine; Pabafilm; Pabamine
| Regulatory & Food Contact | FDA Substance added to food: NUTRIENT SUPPLEMENT CIR / INCI: Uv absorber; Uv filter |
|---|---|
| GHS notification summary | 21.9% (53 / 242) |
| GHS notification summary | 21.9% (53 / 242) |
|---|---|
| Reported hazard statements | H315 (32.2%), H317 (27.7%), H319 (33.1%), H335 (32.2%), H412 (44.6%) |
This chemical does not meet GHS hazard criteria for 21.9% (53 of 242) of reports.
H315 (32.2%): Causes skin irritation [Warning Skin corrosion/irritation]
4-Aminobenzoic acid · CAS 150-13-0 · C7H7NO2. UNII TL2TJE8QTX. Melting Point: 370 to 372 °F (NTP, 1992); Melting Point: 188.5; Melting Point: 188.5 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: p-Aminobenzoic acid