羟甲唑啉（CAS 1491-59-4）：分子式 C16H24N2O、分子量 260.37。
| CAS号 | 1491-59-4 |
|---|---|
| 分子式 | C16H24N2O |
| 分子量 | 260.37 |
| 熔点 | 182 |
| LogP | 3.4 |
| 应用领域 | Uses: THERAP CAT: Adrenergic (vasoconstrictor)、nasal decongestant、MEDICATION、Oxymetazoline nasal spray is a potent、alpha 2、-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa.、Use (kg、approx.) in Germany (2009): >10、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Calculated removal (%): 86.2、Use Classification: Pharmaceuticals、Methods of Manufacturing: From (4-tert-butyl-2、6-dimethyl-3-hydroxyphenyl)acetonitrile & ethylenediamine: FRUHSTORFER、MUELLER-CALGAN...CHEM ABST 57、4674A (1962).、6-t-Butyl-2、4-dimethylphenol + formaldehyde + sodium cyanide + ethylenediamine (chloromethylation、cyanidation、condensation)、Formulations、Preparations: Nasal: Solution: 0.05%* Afrin ( with benzalkonium chloride、povidone、and propylene glycol、with or without menthol and regular drops and spray)、(Schering-Plough)、Afrin No Drip Extra Moisturizing 12 Hour Pump Mist ( with benzalkonium chloride、benzyl alcohol、glycerin、and povidone)、(Schering-Plough) Afrin No Drip Original 12 Hour Pump Mist ( with benzalkonium chloride、Afrin No Drip Severe Congestion 12 Hour Pump Mist ( with benzalkonium chloride、and propylene glycol)、(Schering-Plough) Afrin No Drip Sinus 12 Hour Pump Mist ( with benzalkonium chloride、Dristan 12 Hour Nasal Spray ( with benzalkonium chloride and benzyl alcohol)、(Wyeth)、Duramist Plus 12 Hour Nasal Decongestant Spray ( with benzalkonium chloride)、(Pfeiffer)、4-Way 12 Hour Long Lasting Spray ( with benzalkonium chloride and phenylmercuric acetate)、(Bristol-Myers Squibb)、Nasal Decongestant Maximum Strength Spray ( with benzalkonium chloride、(Taro)、Neo-Synephrine 12 Hour Extra Moisturizing Spray ( with benzalkonium chloride、and phenylmercuric acetate)、(Bayer)、Neo-Synephrine 12 Hour Long Acting Spray ( with benzalkonium chloride and phenylmercuric acetate)、Nostrilla12 Hour Nasal Decongestant ( with benzalkonium chloride、with metered pump spray)、(Insight)、Vicks Sinex 12 Hour Nasal Decongestant Spray ( with benzalkonium chloride and with regular or metered pump mist spray)、(Procter & Gamble).、Ophthalmic: Solution: 0.025% Visine L.R. Eye Drops (with benzalkonium chloride)、(Pfizer).、Trade names: Ocuclear Eye Drops (Schering)、Visine L.R. Eye Drops (Pfizer)、Oxymetazoline hydrochloride、General Manufacturing Information: PATENTS: GERMAN PATENT 1、117、588 (1961 TO E MERCK).、Available commercially as the free base or hydrochloride. |
登记用途：Uses: THERAP CAT: Adrenergic (vasoconstrictor)、nasal decongestant、MEDICATION、Oxymetazoline nasal spray is a potent、alpha 2、-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa.、Use (kg、approx.) in Germany (2009): >10、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Calculated removal (%): 86.2、Use Classification: Pharmaceuticals、Methods of Manufacturing: From (4-tert-butyl-2、6-dimethyl-3-hydroxyphenyl)acetonitrile & ethylenediamine: FRUHSTORFER、MUELLER-CALGAN...CHEM ABST 57、4674A (1962).、6-t-Butyl-2、4-dimethylphenol + formaldehyde + sodium cyanide + ethylenediamine (chloromethylation、cyanidation、condensation)、Formulations、Preparations: Nasal: Solution: 0.05%* Afrin ( with benzalkonium chloride、povidone、and propylene glycol、with or without menthol and regular drops and spray)、(Schering-Plough)、Afrin No Drip Extra Moisturizing 12 Hour Pump Mist ( with benzalkonium chloride、benzyl alcohol、glycerin、and povidone)、(Schering-Plough) Afrin No Drip Original 12 Hour Pump Mist ( with benzalkonium chloride、Afrin No Drip Severe Congestion 12 Hour Pump Mist ( with benzalkonium chloride、and propylene glycol)、(Schering-Plough) Afrin No Drip Sinus 12 Hour Pump Mist ( with benzalkonium chloride、Dristan 12 Hour Nasal Spray ( with benzalkonium chloride and benzyl alcohol)、(Wyeth)、Duramist Plus 12 Hour Nasal Decongestant Spray ( with benzalkonium chloride)、(Pfeiffer)、4-Way 12 Hour Long Lasting Spray ( with benzalkonium chloride and phenylmercuric acetate)、(Bristol-Myers Squibb)、Nasal Decongestant Maximum Strength Spray ( with benzalkonium chloride、(Taro)、Neo-Synephrine 12 Hour Extra Moisturizing Spray ( with benzalkonium chloride、and phenylmercuric acetate)、(Bayer)、Neo-Synephrine 12 Hour Long Acting Spray ( with benzalkonium chloride and phenylmercuric acetate)、Nostrilla12 Hour Nasal Decongestant ( with benzalkonium chloride、with metered pump spray)、(Insight)、Vicks Sinex 12 Hour Nasal Decongestant Spray ( with benzalkonium chloride and with regular or metered pump mist spray)、(Procter & Gamble).、Ophthalmic: Solution: 0.025% Visine L.R. Eye Drops (with benzalkonium chloride)、(Pfizer).、Trade names: Ocuclear Eye Drops (Schering)、Visine L.R. Eye Drops (Pfizer)、Oxymetazoline hydrochloride、General Manufacturing Information: PATENTS: GERMAN PATENT 1、117、588 (1961 TO E MERCK).、Available commercially as the free base or hydrochloride.。
羟甲唑啉 是一种化工化合物，登记 CAS 号为 1491-59-4，分子式 C16H24N2O（分子量 260.37）。
登记 CAS 号：1491-59-4
其分子式 C16H24N2O 由 16 个碳、24 个氢、2 个氮、1 个氧 组成。
别名/同义词：羟甲唑啉 · oxymetazoline
羟甲唑啉 的 CAS 登记号为 1491-59-4。
分子式 C16H24N2O，分子量 260.37。
别名/同义词：羟甲唑啉、oxymetazoline。
登记用途：Uses: THERAP CAT: Adrenergic (vasoconstrictor)、nasal decongestant、MEDICATION、Oxymetazoline nasal spray is a potent、alpha 2、-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa.、Use (kg、approx.) in Germany (2009): >10、Consumption (g per capita、approx.) in Germany (2009): 0.000122、Calculated removal (%): 86.2、Use Classification: Pharmaceuticals、Methods of Manufacturing: From (4-tert-butyl-2、6-dimethyl-3-hydroxyphenyl)acetonitrile & ethylenediamine: FRUHSTORFER、MUELLER-CALGAN...CHEM ABST 57、4674A (1962).、6-t-Butyl-2、4-dimethylphenol + formaldehyde + sodium cyanide + ethylenediamine (chloromethylation、cyanidation、condensation)、Formulations、Preparations: Nasal: Solution: 0.05%* Afrin ( with benzalkonium chloride、povidone、and propylene glycol、with or without menthol and regular drops and spray)、(Schering-Plough)、Afrin No Drip Extra Moisturizing 12 Hour Pump Mist ( with benzalkonium chloride、benzyl alcohol、glycerin、and povidone)、(Schering-Plough) Afrin No Drip Original 12 Hour Pump Mist ( with benzalkonium chloride、Afrin No Drip Severe Congestion 12 Hour Pump Mist ( with benzalkonium chloride、and propylene glycol)、(Schering-Plough) Afrin No Drip Sinus 12 Hour Pump Mist ( with benzalkonium chloride、Dristan 12 Hour Nasal Spray ( with benzalkonium chloride and benzyl alcohol)、(Wyeth)、Duramist Plus 12 Hour Nasal Decongestant Spray ( with benzalkonium chloride)、(Pfeiffer)、4-Way 12 Hour Long Lasting Spray ( with benzalkonium chloride and phenylmercuric acetate)、(Bristol-Myers Squibb)、Nasal Decongestant Maximum Strength Spray ( with benzalkonium chloride、(Taro)、Neo-Synephrine 12 Hour Extra Moisturizing Spray ( with benzalkonium chloride、and phenylmercuric acetate)、(Bayer)、Neo-Synephrine 12 Hour Long Acting Spray ( with benzalkonium chloride and phenylmercuric acetate)、Nostrilla12 Hour Nasal Decongestant ( with benzalkonium chloride、with metered pump spray)、(Insight)、Vicks Sinex 12 Hour Nasal Decongestant Spray ( with benzalkonium chloride and with regular or metered pump mist spray)、(Procter & Gamble).、Ophthalmic: Solution: 0.025% Visine L.R. Eye Drops (with benzalkonium chloride)、(Pfizer).、Trade names: Ocuclear Eye Drops (Schering)、Visine L.R. Eye Drops (Pfizer)、Oxymetazoline hydrochloride、General Manufacturing Information: PATENTS: GERMAN PATENT 1、117、588 (1961 TO E MERCK).、Available commercially as the free base or hydrochloride.。
羟甲唑啉（CAS 1491-59-4）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 1491-59-4 |
|---|---|
| PubChem CID | 4636 |
| Molecular formula | C16H24N2O |
| IUPAC name | 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol |
| UNII (FDA) | 8VLN5B44ZY |
| Molecular Weight | 260.37 |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 3 |
| Exact Mass | 260.188863393 |
| Monoisotopic Mass | 260.188863393 |
| Topological Polar Surface Area | 44.6 |
| Heavy Atom Count | 19 |
| Melting Point | 182 |
|---|---|
| Melting Point | 181-183 °C |
| Melting Point | 182 °C |
| Solubility | 5.15e-02 g/L |
| LogP | 3.4 |
oxymetazoline; 1491-59-4; Oxymethazoline; Hazol; Oximetazolinum; Oxylazine; Rhinofrenol; Sinerol; Iliadin; Navisin; Nezeril; Nafrine; Oxymetozoline; Oximetazolina; Oxymetazolinum; Afrin
| Reported hazard statements | H300, H330 (96.6%), H318 (100%), H412 (100%) |
|---|
H300+H330 (96.6%): Fatal if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
oxymetazoline · CAS 1491-59-4 · C16H24N2O. UNII 8VLN5B44ZY. Melting Point: 182; Melting Point: 181-183 °C; Melting Point: 182 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: oxymetazoline