乳清酸（CAS 65-86-1）：分子式 C5H4N2O4、分子量 156.10。
| CAS号 | 65-86-1 |
|---|---|
| 分子式 | C5H4N2O4 |
| 分子量 | 156.10 |
| 熔点 | 653 to 655 °F (NTP, 1992) |
| LogP | -0.83 |
| 应用领域 | Uses: Biochemical research、especially the biosynthesis of nucleic acids.、Has been proposed as feed supplement in combination with methionine to aid growth of calves.、This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions、catabolic reactions or waste generation.、Methods of Manufacturing: Preparation by condensation of urea with monoethyl ester of oxalacetic acid in methanol: US Patent 2937175 (1963 to Kyowa)、Synthesized from aspartic acid.、Prepn by condensation of urea with monoethyl ester of oxalacetic acid in methanol: Scriabine、US 2937175、The oldest known method for synthesizing orotic acid is the condensation of urea with diethyl oxalacetate and subsequent alkaline hydrolysis of the reaction product. Free orotic acid is obtained from the alkali salt by treatment with mineral acid. A newer synthesis starts by condensing chloroacetoacetyl chlorine、obtained from diketene and chlorine、with urea to give 6-chloromethyluracil. Oxidation of the latter with hydrogen peroxide in an alkaline medium yields orotic acid. In another method、hydantoin or hydantonitrile is treated with glycolic acid in an alkaline medium to give carboxymethylene hydantoin、which rearranges to form orotic acid. Orotic acid is also produced in fermentation by using microorganisms such as Corynebacterium、Brevibacterium.、General Manufacturing Information: 4-Pyrimidinecarboxylic acid、1、2、3、6-tetrahydro-2、6-dioxo-: ACTIVE、Classified as a vitamin (vitamin B13) |
登记用途：Uses: Biochemical research、especially the biosynthesis of nucleic acids.、Has been proposed as feed supplement in combination with methionine to aid growth of calves.、This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions、catabolic reactions or waste generation.、Methods of Manufacturing: Preparation by condensation of urea with monoethyl ester of oxalacetic acid in methanol: US Patent 2937175 (1963 to Kyowa)、Synthesized from aspartic acid.、Prepn by condensation of urea with monoethyl ester of oxalacetic acid in methanol: Scriabine、US 2937175、The oldest known method for synthesizing orotic acid is the condensation of urea with diethyl oxalacetate and subsequent alkaline hydrolysis of the reaction product. Free orotic acid is obtained from the alkali salt by treatment with mineral acid. A newer synthesis starts by condensing chloroacetoacetyl chlorine、obtained from diketene and chlorine、with urea to give 6-chloromethyluracil. Oxidation of the latter with hydrogen peroxide in an alkaline medium yields orotic acid. In another method、hydantoin or hydantonitrile is treated with glycolic acid in an alkaline medium to give carboxymethylene hydantoin、which rearranges to form orotic acid. Orotic acid is also produced in fermentation by using microorganisms such as Corynebacterium、Brevibacterium.、General Manufacturing Information: 4-Pyrimidinecarboxylic acid、1、2、3、6-tetrahydro-2、6-dioxo-: ACTIVE、Classified as a vitamin (vitamin B13)。
乳清酸 是一种化工化合物，登记 CAS 号为 65-86-1，分子式 C5H4N2O4（分子量 156.10）。
登记 CAS 号：65-86-1
其分子式 C5H4N2O4 由 5 个碳、4 个氢、2 个氮、4 个氧 组成。
别名/同义词：乳清酸 · Orotic acid
乳清酸 的 CAS 登记号为 65-86-1。
分子式 C5H4N2O4，分子量 156.10。
别名/同义词：乳清酸、Orotic acid。
登记用途：Uses: Biochemical research、especially the biosynthesis of nucleic acids.、Has been proposed as feed supplement in combination with methionine to aid growth of calves.、This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions、catabolic reactions or waste generation.、Methods of Manufacturing: Preparation by condensation of urea with monoethyl ester of oxalacetic acid in methanol: US Patent 2937175 (1963 to Kyowa)、Synthesized from aspartic acid.、Prepn by condensation of urea with monoethyl ester of oxalacetic acid in methanol: Scriabine、US 2937175、The oldest known method for synthesizing orotic acid is the condensation of urea with diethyl oxalacetate and subsequent alkaline hydrolysis of the reaction product. Free orotic acid is obtained from the alkali salt by treatment with mineral acid. A newer synthesis starts by condensing chloroacetoacetyl chlorine、obtained from diketene and chlorine、with urea to give 6-chloromethyluracil. Oxidation of the latter with hydrogen peroxide in an alkaline medium yields orotic acid. In another method、hydantoin or hydantonitrile is treated with glycolic acid in an alkaline medium to give carboxymethylene hydantoin、which rearranges to form orotic acid. Orotic acid is also produced in fermentation by using microorganisms such as Corynebacterium、Brevibacterium.、General Manufacturing Information: 4-Pyrimidinecarboxylic acid、1、2、3、6-tetrahydro-2、6-dioxo-: ACTIVE、Classified as a vitamin (vitamin B13)。
乳清酸（CAS 65-86-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 65-86-1 |
|---|---|
| PubChem CID | 967 |
| Molecular formula | C5H4N2O4 |
| IUPAC name | 2,4-dioxo-1H-pyrimidine-6-carboxylic acid |
| UNII (FDA) | 61H4T033E5 |
| Molecular Weight | 156.10 |
|---|---|
| XLogP3 | -1.4 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 156.01710661 |
| Monoisotopic Mass | 156.01710661 |
| Topological Polar Surface Area | 95.5 |
| Heavy Atom Count | 11 |
| Melting Point | 653 to 655 °F (NTP, 1992) |
|---|---|
| Melting Point | 345.5 |
| Melting Point | 345-346 °C |
| Melting Point | 345.5 °C |
| Solubility | 1820 |
| Solubility | In water, 1,820 mg/L at 25 °C |
| Solubility | 1.82 mg/mL at 18 °C |
| LogP | -0.83 |
| LogP | log Kow = -0.83 |
| Dissociation Constants | pKa1 = 2.07; pKa2 = 9.45 |
Orotic acid; 65-86-1; 6-Carboxyuracil; Oropur; Orodin; Orotyl; Vitamin B13; Orotonin; Whey factor; Orotonsan; Animal galactose factor; Uracil-6-carboxylic acid; 6-Uracilcarboxylic acid; Molkensaeure; Orotsaeure; Acido orotico
| GHS notification summary | 6.7% (4 / 60) |
|---|
| GHS notification summary | 6.7% (4 / 60) |
|---|---|
| Reported hazard statements | H302 (93.3%), H315 (88.3%), H319 (88.3%), H335 (81.7%) |
This chemical does not meet GHS hazard criteria for 6.7% (4 of 60) of reports.
H302 (93.3%): Harmful if swallowed [Warning Acute toxicity, oral]
Orotic acid · CAS 65-86-1 · C5H4N2O4. UNII 61H4T033E5. Melting Point: 653 to 655 °F (NTP, 1992); Melting Point: 345.5; Melting Point: 345-346 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Orotic acid