奥氮平（CAS 132539-06-1）：分子式 C17H20N4S、分子量 312.4。
| CAS号 | 132539-06-1 |
|---|---|
| 分子式 | C17H20N4S |
| 分子量 | 312.4 |
| 熔点 | 189-195 °C |
| 沸点 | 476 |
| LogP | 4.094 |
| 应用领域 | Uses: THERAPEUTIC CATEGORY: Antipsychotic、Antiemetic、Antipsychotic Agent、Serotonin Uptake Inhibitor、MEDICATION、Use (kg) in Switzerland (2009): >50、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 1950、Consumption (g per capita) in Switzerland (2009): 0.0064、Consumption (g per capita、approx.) in Germany (2009): 0.0031、Consumption (g per capita) in the USA (2002): 0.0069、Excretion rate: 1、Calculated removal (%): 14.6、For the acute and maintenance treatment of schizophrenia and related psychotic disorders、as well as acute treatment of manic or mixed episodes of bipolar 1 disorder. Intramuscular olanzapine is indicated for the rapid control of agitated patients.、Use Classification: Pharmaceuticals、Methods of Manufacturing: A mixture of sulfur、propanol、DMF、and trimethylamine are heated during the addition of malononitrile to produce 2-amino-5-methylthiophene-3-carbonitrile. Reaction of this compound with 2-fluoronitrobenzene and sodium hydride form 2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile、which is subsequently treated with anhydrous stannous chloride to close the diazepine ring. The diazepine with 1-methylpiperazine in DMSO yields the product (base).、Preparation: J. K. Chakrabarti et al.、European Patent Office 454436、eidem、United States of America patent 5229382 (1991、1993 both to Lilly)、Formulations、Preparations: Table: Olanzapine Preparations [Table#8116]、Table: Olanzapine Combination Preparations [Table#8117] |
登记用途：Uses: THERAPEUTIC CATEGORY: Antipsychotic、Antiemetic、Antipsychotic Agent、Serotonin Uptake Inhibitor、MEDICATION、Use (kg) in Switzerland (2009): >50、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 1950、Consumption (g per capita) in Switzerland (2009): 0.0064、Consumption (g per capita、approx.) in Germany (2009): 0.0031、Consumption (g per capita) in the USA (2002): 0.0069、Excretion rate: 1、Calculated removal (%): 14.6、For the acute and maintenance treatment of schizophrenia and related psychotic disorders、as well as acute treatment of manic or mixed episodes of bipolar 1 disorder. Intramuscular olanzapine is indicated for the rapid control of agitated patients.、Use Classification: Pharmaceuticals、Methods of Manufacturing: A mixture of sulfur、propanol、DMF、and trimethylamine are heated during the addition of malononitrile to produce 2-amino-5-methylthiophene-3-carbonitrile. Reaction of this compound with 2-fluoronitrobenzene and sodium hydride form 2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile、which is subsequently treated with anhydrous stannous chloride to close the diazepine ring. The diazepine with 1-methylpiperazine in DMSO yields the product (base).、Preparation: J. K. Chakrabarti et al.、European Patent Office 454436、eidem、United States of America patent 5229382 (1991、1993 both to Lilly)、Formulations、Preparations: Table: Olanzapine Preparations [Table#8116]、Table: Olanzapine Combination Preparations [Table#8117]。
奥氮平 是一种化工化合物，登记 CAS 号为 132539-06-1，分子式 C17H20N4S（分子量 312.4）。
登记 CAS 号：132539-06-1
其分子式 C17H20N4S 由 17 个碳、20 个氢、4 个氮、1 个硫 组成。
别名/同义词：奥氮平 · Olanzapine
奥氮平 的 CAS 登记号为 132539-06-1。
分子式 C17H20N4S，分子量 312.4。
别名/同义词：奥氮平、Olanzapine。
登记用途：Uses: THERAPEUTIC CATEGORY: Antipsychotic、Antiemetic、Antipsychotic Agent、Serotonin Uptake Inhibitor、MEDICATION、Use (kg) in Switzerland (2009): >50、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 1950、Consumption (g per capita) in Switzerland (2009): 0.0064、Consumption (g per capita、approx.) in Germany (2009): 0.0031、Consumption (g per capita) in the USA (2002): 0.0069、Excretion rate: 1、Calculated removal (%): 14.6、For the acute and maintenance treatment of schizophrenia and related psychotic disorders、as well as acute treatment of manic or mixed episodes of bipolar 1 disorder. Intramuscular olanzapine is indicated for the rapid control of agitated patients.、Use Classification: Pharmaceuticals、Methods of Manufacturing: A mixture of sulfur、propanol、DMF、and trimethylamine are heated during the addition of malononitrile to produce 2-amino-5-methylthiophene-3-carbonitrile. Reaction of this compound with 2-fluoronitrobenzene and sodium hydride form 2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile、which is subsequently treated with anhydrous stannous chloride to close the diazepine ring. The diazepine with 1-methylpiperazine in DMSO yields the product (base).、Preparation: J. K. Chakrabarti et al.、European Patent Office 454436、eidem、United States of America patent 5229382 (1991、1993 both to Lilly)、Formulations、Preparations: Table: Olanzapine Preparations [Table#8116]、Table: Olanzapine Combination Preparations [Table#8117]。
奥氮平（CAS 132539-06-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 132539-06-1 |
|---|---|
| PubChem CID | 135398745 |
| Molecular formula | C17H20N4S |
| IUPAC name | 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine |
| UNII (FDA) | N7U69T4SZR |
| Molecular Weight | 312.4 |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 312.14086783 |
| Monoisotopic Mass | 312.14086783 |
| Topological Polar Surface Area | 59.1 |
| Heavy Atom Count | 22 |
| Boiling Point | 476 |
|---|---|
| Melting Point | 189-195 °C |
| Melting Point | 195 °C |
| LogP | 4.094 |
| LogP | log Kow = 3.00 |
| LogP | 3.0 |
| Dissociation Constants | 7.8 |
| Dissociation Constants | 10.57 |
| Collision Cross Section | 175.78 Ų [M+H]+ |
olanzapine; 132539-06-1; Olansek; Zyprexa Zydis; Zalasta; Zyprexa Velotab; Zyprexa Intramuscular; olanzapina; Olanzapine Mylan; LY-170053; 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine; 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine; Olazax; Olanzapine Teva; Olazax Disperzi; Olanzapine Glenmark
| Reported hazard statements | H301 (31.1%), H315 (75.4%), H317 (26.2%), H319 (91.8%), H336 (16.4%), H373 (16.4%) |
|---|
H301 (31.1%): Toxic if swallowed [Danger Acute toxicity, oral]
H315 (75.4%): Causes skin irritation [Warning Skin corrosion/irritation]
Olanzapine · CAS 132539-06-1 · C17H20N4S. UNII N7U69T4SZR. Boiling Point: 476; Melting Point: 189-195 °C; Melting Point: 195 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Olanzapine