新生霉素（CAS 303-81-1）：分子式 C31H36N2O11、分子量 612.6。
| CAS号 | 303-81-1 |
|---|---|
| 分子式 | C31H36N2O11 |
| 分子量 | 612.6 |
| 熔点 | 152-156 °C (decomposes) |
| LogP | 4.1 |
| 应用领域 | Uses: Mesh Heading: anti-bacterial agents、enzyme inhibitors、MEDICATION (VET)、Medicinal feed additive for chicken and turkey、Novobiocin is a narrow-spectrum antibiotic that may be bacteriostatic or bactericidal at higher concentrations. It is active mostly against gram-positive bacteria but also against a few gram-negative bacteria. ... Its main use is in combination with other agents for the treatment of bovine mastitis.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Antibiotic substance produced by Streptomyces spheroides ... US patent 3、000、873 (1961 to Merck and Co.) ... US patents 3、049、475、3、476、534 (1962 to Merck and Co.). ... Synthesis ... US patents 2、925、411 (1960)、2、966、484 (1960 to Merck and Co.).、Produced、by Streptomyces niveus、US patent 3068221 (1962 to Upjohn). ... Conversion of isonovobiocin to novobiocin: US patent 2983723 (1961 to Upjohn). |
登记用途：Uses: Mesh Heading: anti-bacterial agents、enzyme inhibitors、MEDICATION (VET)、Medicinal feed additive for chicken and turkey、Novobiocin is a narrow-spectrum antibiotic that may be bacteriostatic or bactericidal at higher concentrations. It is active mostly against gram-positive bacteria but also against a few gram-negative bacteria. ... Its main use is in combination with other agents for the treatment of bovine mastitis.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Antibiotic substance produced by Streptomyces spheroides ... US patent 3、000、873 (1961 to Merck and Co.) ... US patents 3、049、475、3、476、534 (1962 to Merck and Co.). ... Synthesis ... US patents 2、925、411 (1960)、2、966、484 (1960 to Merck and Co.).、Produced、by Streptomyces niveus、US patent 3068221 (1962 to Upjohn). ... Conversion of isonovobiocin to novobiocin: US patent 2983723 (1961 to Upjohn).。
新生霉素 是一种化工化合物，登记 CAS 号为 303-81-1，分子式 C31H36N2O11（分子量 612.6）。
登记 CAS 号：303-81-1
其分子式 C31H36N2O11 由 31 个碳、36 个氢、2 个氮、11 个氧 组成。
别名/同义词：新生霉素 · novobiocin
新生霉素 的 CAS 登记号为 303-81-1。
分子式 C31H36N2O11，分子量 612.6。
别名/同义词：新生霉素、novobiocin。
登记用途：Uses: Mesh Heading: anti-bacterial agents、enzyme inhibitors、MEDICATION (VET)、Medicinal feed additive for chicken and turkey、Novobiocin is a narrow-spectrum antibiotic that may be bacteriostatic or bactericidal at higher concentrations. It is active mostly against gram-positive bacteria but also against a few gram-negative bacteria. ... Its main use is in combination with other agents for the treatment of bovine mastitis.、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> ANTIMICROBIAL_AGENT -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Methods of Manufacturing: Antibiotic substance produced by Streptomyces spheroides ... US patent 3、000、873 (1961 to Merck and Co.) ... US patents 3、049、475、3、476、534 (1962 to Merck and Co.). ... Synthesis ... US patents 2、925、411 (1960)、2、966、484 (1960 to Merck and Co.).、Produced、by Streptomyces niveus、US patent 3068221 (1962 to Upjohn). ... Conversion of isonovobiocin to novobiocin: US patent 2983723 (1961 to Upjohn).。
新生霉素（CAS 303-81-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 303-81-1 |
|---|---|
| PubChem CID | 54675769 |
| Molecular formula | C31H36N2O11 |
| IUPAC name | [(3R,4S,5R,6R)-5-hydroxy-6-[4-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-2-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate |
| UNII (FDA) | 17EC19951N |
| Molecular Weight | 612.6 |
|---|---|
| XLogP3 | 3.3 |
| Hydrogen Bond Donor Count | 5 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 9 |
| Exact Mass | 612.23190997 |
| Monoisotopic Mass | 612.23190997 |
| Topological Polar Surface Area | 196 |
| Heavy Atom Count | 44 |
| Melting Point | 152-156 °C (decomposes) |
|---|---|
| Solubility | 9.66e-03 g/L |
| Density | 1.3448 g/cu cm |
| LogP | 4.1 |
| LogP | 1.33 |
| Dissociation Constants | 4.3 |
novobiocin; 303-81-1; Streptonivicin; Cardelmycin; Inamycin; Spheromycin; Novobiocina; Novobiocine; Crystallinic acid; Cathocin; Novobiocinum; PA 93; 17EC19951N; DTXSID3041083; CHEBI:28368; NSC2382
| Regulatory & Food Contact | ANTIMICROBIAL_AGENT: Veterinary Drug NMRS 45/TRS 430-JECFA 12/43 |
|---|
| Reported hazard statements | H302 (100%), H317 (100%) |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
novobiocin · CAS 303-81-1 · C31H36N2O11. UNII 17EC19951N. Melting Point: 152-156 °C (decomposes); Solubility: 9.66e-03 g/L; Density: 1.3448 g/cu cm.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: novobiocin