尼罗替尼及其中间体

Name: 尼罗替尼及其中间体
Brand: 济南圣和化工有限公司

CAS 641571-10-0C28H22F3N7OMW 529.5

本页收录尼罗替尼及其中间体，CAS 登记号为 641571-10-0，分子式 C28H22F3N7O，分子量 529.5，归类于化工中间体。作为主营产品之一，济南圣和化工有限公司可提供从公斤级到吨级的稳定供货，随货附 COA 与质检资料。

产品概览

CAS号	641571-10-0
分子式	C28H22F3N7O
分子量	529.5
LogP	4.9
纯度	按批次COA提供(不公开发布)
包装	按订单/批次确认(不公开发布)
应用领域	化工中间体
类别	化工中间体

应用领域

化工中间体

该产品的下游应用集中在化工中间体。不同客户工艺差异较大，我们支持按需提供样品与小批量试用。

包装与储存

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

运输常规化工运输

样品可协商提供

交期现货/按订单安排

供货能力：尼罗替尼及其中间体备有现货，包装形式为按订单/批次确认(不公开发布)。我们支持对公转账并开具增值税发票，山东省内可安排快速配送，省外按物流时效发货，具体请联系 info@591daili.com。

质量与文件

每批产品随货提供 COA（分析证书）；可按需提供 MSDS/技术数据表及第三方检测报告。纯度与包装以批次 COA 及订单确认为准。

关于供应商

选择济南圣和化工有限公司的理由：产品信息透明（含 CAS、分子式、理化参数）、报价响应快（一个工作日内）、单证齐全（COA/MSS/质检资料按需提供）、支持批量与长期协议供货。如需尼罗替尼及其中间体以外的配套原料，也欢迎一并列出需求清单。

常见问题

尼罗替尼及其中间体的 CAS 号是多少？

尼罗替尼及其中间体的 CAS 号为 641571-10-0。

该产品的纯度和包装规格是什么？

常规纯度规格为按批次COA提供(不公开发布)，包装为按订单/批次确认(不公开发布)，随货提供 COA。

尼罗替尼及其中间体有什么用途？

主要应用于化工中间体。

如何购买或获取报价？

请发送邮件至 info@591daili.com 或通过 WhatsApp 联系，注明产品名称、CAS 号与需求数量，一个工作日内回复报价。供应商：济南圣和化工有限公司。

PubChem 公开数据

Description

Nilotinib & its intermediates · CAS 641571-10-0 · C28H22F3N7O. UNII F41401512X. Solubility: 2.01e-03 g/L; Dissociation Constants: pKa1 = 2.1; pKa2 = 5.4.

Identification

CAS Registry Number	641571-10-0
PubChem CID	644241
Molecular formula	C28H22F3N7O
IUPAC name	4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
UNII (FDA)	F41401512X

Computed Descriptors

Molecular Weight	529.5
XLogP3	4.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	529.18379284
Monoisotopic Mass	529.18379284
Topological Polar Surface Area	97.6
Heavy Atom Count	39
Formal Charge	0

Physical & Chemical Properties

Solubility	2.01e-03 g/L
Dissociation Constants	pKa1 = 2.1; pKa2 = 5.4

Physical description & handling notes

Solid
White to slightly yellowish to slightly greenish yellow powder
The solubility ... in aqueous solutions decreases with increasing pH
A monohydrate monohydrochloride
Nilotinib is a transduction inhibitor that targets BCR-ABL, c-kit and PDGF, for the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
Nilotinib preparations: (AHFS, 2010):

GHS Hazard Classification

Reported hazard statements	H361 (69.2%), H372 (15.4%), H373 (76.9%), H400 (69.2%), H410 (69.2%), H413 (23.1%)

H361 (69.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361fd (46.2%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]

Documented Uses

Use (kg; approx.) in Germany (2009): >75
Consumption (g per capita; approx.) in Germany (2009): 0.000916
For the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia. Nilotinib therapy is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.
Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
Oral - Solid - capsule: 150 mg; 200 mg

Synonyms

Nilotinib; 641571-10-0; AMN 107; AMN-107; nilotinibum; Danziten; NSC-747599; DTXSID5042663; F41401512X; CHEBI:52172; RefChem:58968; AMN 107 Base; DTXCID3022663; L01XE08; Tasigna; AMN107

Frequently Asked Questions

What are the CAS number and molecular formula of Nilotinib & its intermediates?

CAS 641571-10-0; molecular formula C28H22F3N7O; molecular weight — g/mol.

What other names is Nilotinib & its intermediates known by?

Nilotinib, 641571-10-0, AMN 107, AMN-107, nilotinibum, Danziten.

Is Nilotinib & its intermediates classified as hazardous?

Hazard statements reported: H361, H372, H373, H400, H410.

What are the key physical properties of Nilotinib & its intermediates?

Solubility: 2.01e-03 g/L; Dissociation Constants: pKa1 = 2.1; pKa2 = 5.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.