Nicotinic acid

Nicotinic acid (CAS 59-67-6) — formula C6H5NO2, molecular weight 123.03 g/mol.

Product Overview

Applications

Documented applications: Uses: CIR ingredient: Niacin, Occurs naturally especially in liver, fish, yeast, and cereal grains, Used as a drug (antilipemic and vitamin), [Merck Index] Used in the chemical, agricultural, animal feed, and food industries, in cosmetics, pharmaceuticals, as a food additive, intermediate, and laboratory chemical, [IUCLID] Used as a medication, nutrient, in animal feeds, enriched flours, as a chemical intermediate, and in electroplating bathes, [HSDB] Used as a nutritional supplement, [FDA] Permitted for use as an inert ingredient in non-food pesticide products, [EPA], Electroplating [Category: Plate], Farming (Feed Additives) [Category: Industry], Hypolipidemic Agents, Vasodilator Agents, Vitamin B Complex, For nicotinic acid (USEPA, OPP Pesticide Code: 056701) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., Medicine (cholesterol-lowering agent), nutrition, feeds, dietary supplement, ..., Has, been used in the enrichment of bread, flour, and other grain-derived products. Animal feed is routinely supplemented with nicotinic acid ... ., For more Uses (Complete) data for Nicotinic acid (8 total), please visit the HSDB record page., Synthetic Polymer MALDI Matrix Compounds, Use (kg, approx.) in Germany (2009): >2500, Use (kg) in USA (2002): 97300, Consumption (g per capita, approx.) in Germany (2009): 0.0305, Consumption (g per capita) in the USA (2002): 0.345, Calculated removal (%): 92.1, For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy. It can be found in various foods, such as liver, chicken, beef, cereal, peanuts and legumes. Niacin is also used as a pharmaceutical to reverse atherosclerosis. (A729), Use Classification: Cosmetics -> Smoothing, Antistatic, Industry Uses: Flavoring and nutrient, Intermediate, Consumer Uses: Flavoring and nutrient, Household Products: Information on 1 consumer products that contain Niacin in the following categories is provided:, • Personal Care, Methods of Manufacturing: In an aqueous solution 5-ethyl-2-methylpyridine is oxidized to nicotinic acid in a single-tube reactor by using an excess of nitric acid. The continuous process takes place at 230-270 °C and 6-8 MPa. Pyridine-2, 5-dicarboxylic acid is formed as an intermediate, but is not stable under the reaction conditions, undergoing decarboxylation to nicotinic acid nitrate. Neutralization of the nitrate with 5-ethyl-2-methylpyridine yields nicotinic acid. Water and carbon dioxide formed in the reaction are separated from the product. The nitrogen oxide formed is oxidized with air to nitrogen dioxide and then absorbed in water to yield nitric acid, which is recycled into the process., Preparation by oxidation of alkyl beta-substituted pyridines, Preparation by oxidation of nicotine, Commercial sources: Synthetic nicotinic acid is made by oxidation of nicotine, quinoline, or 2-methyl-5-ethylpyridine (from ammonia and formaldehyde or acetaldehyde)., Formulations, Preparations: Table: Niacin Preparations [Table#4463], Table: Niacin Combination Preparations [Table#4464], Table: Niacin Preparations [Table#4465], Grades: National Formulary, Food Chemical Codex, blended with soy flour (animal feeds), Niacin is commercially available as conventional (immediate-release) and extended-release preparations and in fixed combination with lovastatin. Niacin also is available as a dietary supplement, these preparations are not FDA-labeled for management of dyslipidemias and should not be used as substitutes for prescription-only niacin preparations., U.S. Production: 2023: 235, 012 lb, 2022: 334, 132 lb, 2021: 710, 858 lb, 2020: 396, 391 lb, (1972) 2.49X10+9 GRAMS, NIACIN & NICOTINAMIDE, (1975) 2.5X10+9 GRAMS, Non-confidential 2016 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Nicotinic acid:, Table: National Aggregate Production Volume (pounds) [Table#4468], General Manufacturing Information: Pharmaceutical and Medicine Manufacturing, Food, beverage, and tobacco product manufacturing, Other (requires additional information), 3-Pyridinecarboxylic acid: ACTIVE, Niacin is a naturally occurring substance. Nicotinic acid is the form present in food of plant origin, whereas nicotinamide occurs in animal products., The terms niacin, Vitamin B3, and Vitamin PP have been used to refer to both nicotinamide and nicotinic acid., NIACIN, MOST STABLE OF VIT, IS NOT DESTROYED BY HEATING IN ACID OR ALKALINE SOLN. IT WITHSTANDS MILD OXIDATION, & RETAINS ITS BIOLOGICAL ACTIVITY DURING PROCESSING OF FOOD & PREPN & STORAGE OF PHARMACEUTICALS., RECOMMENDED ALLOWANCE OF THE DIETARY ALLOWANCES COMMITTEE OF THE NATIONAL RESEARCH COUNCIL, EXPRESSED IN NICOTINIC ACID EQUIVALENTS, IS 6.6 MG, 1000 KCAL..

Technical Profile

What this product is

Nicotinic acid is a chemical compound with CAS registry number 59-67-6 and molecular formula C6H5NO2 (molecular weight 123.03 g/mol).

Identification

CAS number: 59-67-6

Its molecular formula C6H5NO2 comprises 6 C, 5 H, 1 N, 2 O atoms.

Also known as: Nicotinic acid · 烟酸 · Vitamin B3

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