没食子酸正丙酯（CAS 56274-95-4）：分子式 C10H12O5、分子量 212.20。
| CAS号 | 56274-95-4 |
|---|---|
| 分子式 | C10H12O5 |
| 分子量 | 212.20 |
| 熔点 | 302 °F (NTP, 1992) |
| LogP | log Kow = 1.80 |
| 应用领域 | Uses: CIR ingredient: Propyl Gallate、Used as antioxidant to prevent rancidity in fats、oils、and other food products、Also used as a laboratory reagent and stabilizer for synthetic vitamin A、[HSDB] Used as an antioxidant for cosmetics、ethers、emulsions、waxes、and transformer oils、[Merck Index] Contact dermatitis documented in a baker and confectioner、[Kanerva、p. 1830]、Reported uses (ppm):、Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association、1994) [Table#1691]、It is used as an antioxidant for foods and cosmetics、especially fats、and waxes. It is also used in transformer oils and as a stabilizer for synthetic vitamin A.、Reactive peroxides in povidone often lead to degradation of oxidation-labile drugs. ... The antioxidants ascorbic acid、propyl gallate、and sodium sulfite reduced the peroxide concentration in povidone ... .、Synthetic antioxidants commonly used in food include butylated hydroxyanisole (BHA)、butylated hydroxytoluene (BHT)、propyl gallate (PG)、and tert-butylhydroquinone (TBHQ).、MEDICATION、Use Classification: Food additives、Fragrance Ingredients、Food Additives -> ANTIOXIDANT -> JECFA Functional Classes、Cosmetics -> Antioxidant、Household Products: Information on 8 consumer products that contain Propyl gallate in the following categories is provided:、• Personal Care、Methods of Manufacturing: Propyl gallate is manufactured via a reaction of n-propanol with 3、4、5-trihydroxybenzoic acid.、Produced commercially by the esterification of gallic acid with propyl alcohol followed by distillation to remove the excess alcohol.、REACTION OF N-PROPYL ALCOHOL WITH 3、5-TRIHYDROXYBENZOIC ACID、Formulations、Preparations: Trade Names: NIPA 49、Nipagallin P、Progallin P、and Tenox PG.、The antioxidant formulations most commonly used in edible products contain various combinations of BHA、BHT、and、or propyl gallate together with citric acid in a suitable solvent.、U.S. Production: (1975) PROBABLY GREATER THAN 9.08X10+5 GRAMS、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzoic acid、3、5-trihydroxy-、propyl ester. National Production Volume: 232、076 lb、yr.、General Manufacturing Information: Benzoic acid、propyl ester: ACTIVE、The Panel on Food Additives and Nutrient Sources added to Food (ANS)、European Food Safety Authority (EFSA)、concluded in a 2014 report、that the use of propyl gallate as food additive at the current uses and use levels is not of safety concern.、Propyl gallate is used as an antioxidant in pesticide formulations at typical concentrations of 0.25% or less.、Used in foods restricted to 0.02% of fat content.、or propyl gallate together with citric acid in suitable solvent.、Tocopherols、gum guaiac、and similar natural antioxidants usually lack potency in most products compared to combinations of BHA、butylated hydroxyanisole、butylated hydroxytoluene、and propyl gallate. |
登记用途：Uses: CIR ingredient: Propyl Gallate、Used as antioxidant to prevent rancidity in fats、oils、and other food products、Also used as a laboratory reagent and stabilizer for synthetic vitamin A、[HSDB] Used as an antioxidant for cosmetics、ethers、emulsions、waxes、and transformer oils、[Merck Index] Contact dermatitis documented in a baker and confectioner、[Kanerva、p. 1830]、Reported uses (ppm):、Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association、1994) [Table#1691]、It is used as an antioxidant for foods and cosmetics、especially fats、and waxes. It is also used in transformer oils and as a stabilizer for synthetic vitamin A.、Reactive peroxides in povidone often lead to degradation of oxidation-labile drugs. ... The antioxidants ascorbic acid、propyl gallate、and sodium sulfite reduced the peroxide concentration in povidone ... .、Synthetic antioxidants commonly used in food include butylated hydroxyanisole (BHA)、butylated hydroxytoluene (BHT)、propyl gallate (PG)、and tert-butylhydroquinone (TBHQ).、MEDICATION、Use Classification: Food additives、Fragrance Ingredients、Food Additives -> ANTIOXIDANT -> JECFA Functional Classes、Cosmetics -> Antioxidant、Household Products: Information on 8 consumer products that contain Propyl gallate in the following categories is provided:、• Personal Care、Methods of Manufacturing: Propyl gallate is manufactured via a reaction of n-propanol with 3、4、5-trihydroxybenzoic acid.、Produced commercially by the esterification of gallic acid with propyl alcohol followed by distillation to remove the excess alcohol.、REACTION OF N-PROPYL ALCOHOL WITH 3、5-TRIHYDROXYBENZOIC ACID、Formulations、Preparations: Trade Names: NIPA 49、Nipagallin P、Progallin P、and Tenox PG.、The antioxidant formulations most commonly used in edible products contain various combinations of BHA、BHT、and、or propyl gallate together with citric acid in a suitable solvent.、U.S. Production: (1975) PROBABLY GREATER THAN 9.08X10+5 GRAMS、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzoic acid、3、5-trihydroxy-、propyl ester. National Production Volume: 232、076 lb、yr.、General Manufacturing Information: Benzoic acid、propyl ester: ACTIVE、The Panel on Food Additives and Nutrient Sources added to Food (ANS)、European Food Safety Authority (EFSA)、concluded in a 2014 report、that the use of propyl gallate as food additive at the current uses and use levels is not of safety concern.、Propyl gallate is used as an antioxidant in pesticide formulations at typical concentrations of 0.25% or less.、Used in foods restricted to 0.02% of fat content.、or propyl gallate together with citric acid in suitable solvent.、Tocopherols、gum guaiac、and similar natural antioxidants usually lack potency in most products compared to combinations of BHA、butylated hydroxyanisole、butylated hydroxytoluene、and propyl gallate.。
没食子酸正丙酯 是一种化工化合物，登记 CAS 号为 56274-95-4，分子式 C10H12O5（分子量 212.20）。
登记 CAS 号：56274-95-4
其分子式 C10H12O5 由 10 个碳、12 个氢、5 个氧 组成。
别名/同义词：没食子酸正丙酯 · n-Propyl Gallate
没食子酸正丙酯 的 CAS 登记号为 56274-95-4。
分子式 C10H12O5，分子量 212.20。
别名/同义词：没食子酸正丙酯、n-Propyl Gallate。
登记用途：Uses: CIR ingredient: Propyl Gallate、Used as antioxidant to prevent rancidity in fats、oils、and other food products、Also used as a laboratory reagent and stabilizer for synthetic vitamin A、[HSDB] Used as an antioxidant for cosmetics、ethers、emulsions、waxes、and transformer oils、[Merck Index] Contact dermatitis documented in a baker and confectioner、[Kanerva、p. 1830]、Reported uses (ppm):、Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association、1994) [Table#1691]、It is used as an antioxidant for foods and cosmetics、especially fats、and waxes. It is also used in transformer oils and as a stabilizer for synthetic vitamin A.、Reactive peroxides in povidone often lead to degradation of oxidation-labile drugs. ... The antioxidants ascorbic acid、propyl gallate、and sodium sulfite reduced the peroxide concentration in povidone ... .、Synthetic antioxidants commonly used in food include butylated hydroxyanisole (BHA)、butylated hydroxytoluene (BHT)、propyl gallate (PG)、and tert-butylhydroquinone (TBHQ).、MEDICATION、Use Classification: Food additives、Fragrance Ingredients、Food Additives -> ANTIOXIDANT -> JECFA Functional Classes、Cosmetics -> Antioxidant、Household Products: Information on 8 consumer products that contain Propyl gallate in the following categories is provided:、• Personal Care、Methods of Manufacturing: Propyl gallate is manufactured via a reaction of n-propanol with 3、4、5-trihydroxybenzoic acid.、Produced commercially by the esterification of gallic acid with propyl alcohol followed by distillation to remove the excess alcohol.、REACTION OF N-PROPYL ALCOHOL WITH 3、5-TRIHYDROXYBENZOIC ACID、Formulations、Preparations: Trade Names: NIPA 49、Nipagallin P、Progallin P、and Tenox PG.、The antioxidant formulations most commonly used in edible products contain various combinations of BHA、BHT、and、or propyl gallate together with citric acid in a suitable solvent.、U.S. Production: (1975) PROBABLY GREATER THAN 9.08X10+5 GRAMS、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Benzoic acid、3、5-trihydroxy-、propyl ester. National Production Volume: 232、076 lb、yr.、General Manufacturing Information: Benzoic acid、propyl ester: ACTIVE、The Panel on Food Additives and Nutrient Sources added to Food (ANS)、European Food Safety Authority (EFSA)、concluded in a 2014 report、that the use of propyl gallate as food additive at the current uses and use levels is not of safety concern.、Propyl gallate is used as an antioxidant in pesticide formulations at typical concentrations of 0.25% or less.、Used in foods restricted to 0.02% of fat content.、or propyl gallate together with citric acid in suitable solvent.、Tocopherols、gum guaiac、and similar natural antioxidants usually lack potency in most products compared to combinations of BHA、butylated hydroxyanisole、butylated hydroxytoluene、and propyl gallate.。
没食子酸正丙酯（CAS 56274-95-4）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 56274-95-4 |
|---|---|
| PubChem CID | 4947 |
| Molecular formula | C10H12O5 |
| IUPAC name | propyl 3,4,5-trihydroxybenzoate |
| UNII (FDA) | 8D4SNN7V92 |
| FEMA number | 2947 |
| Molecular Weight | 212.20 |
|---|---|
| XLogP3 | 1.8 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Exact Mass | 212.06847348 |
| Monoisotopic Mass | 212.06847348 |
| Topological Polar Surface Area | 87 |
| Heavy Atom Count | 15 |
| Melting Point | 302 °F (NTP, 1992) |
|---|---|
| Melting Point | 147-149 °C |
| Melting Point | 150 °C |
| Flash Point | 368 °F (NTP, 1992) |
| Flash Point | 187 °C (369 °F) - closed cup |
| Solubility | 3.5 mg/mL at 25 °C |
| Density | 1.21 |
| LogP | log Kow = 1.80 |
| LogP | 1.80 |
| LogP | 1.8 |
propyl gallate; 121-79-9; Propyl 3,4,5-trihydroxybenzoate; N-Propyl gallate; Progallin P; Gallic acid, propyl ester; Tenox PG; Nipagallin P; Gallic acid propyl ester; NIPA 49; Propylester kyseliny gallove; Benzoic acid, 3,4,5-trihydroxy-, propyl ester; FEMA No. 2947; n-Propyl 3,4,5-trihydroxybenzoate; 3,4,5-Trihydroxybenzene-1-propylcarboxylate; Gallate, Propyl
| Regulatory & Food Contact | FDA Substance added to food: ANTIOXIDANT, FLAVORING AGENT OR ADJUVANT FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS ANTIOXIDANT: Food Additives JECFA ADI: 0-1.4 mg/kg bw (1993) The 1993 ADI was maintained at the forty-sixth meeting (1996) TRS 868-JECFA 46/15 |
|---|
| Reported hazard statements | H302, H317, H400, H410, H318, H411, H334 |
|---|
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
n-Propyl Gallate · CAS 56274-95-4 · C10H12O5. UNII 8D4SNN7V92. Melting Point: 302 °F (NTP, 1992); Melting Point: 147-149 °C; Melting Point: 150 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: n-Propyl Gallate