N-氨甲酰-L-谷氨酸

N-氨甲酰-L-谷氨酸（CAS 1188-38-1）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的理化数值

在册的记载用途

For the treatment of acute and chronic hyperammonaemia in patients with N-acetylglutamate synthase (NAGS) deficiency. This enzyme is an important component of the urea cycle to prevent build up of neurotoxic ammonium in the blood.Carglumic acid is an orphan drug and a derivative of N-acetylglutamate that activates the first enzyme in the urea cycle that is responsible for removal and detoxification of ammonia, making this drug a valuable agent for therapy of hyperammonemia caused by rare forms of urea cycle defects. Clinical experience with carglumic acid is limited, but it has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.

同义词与商品名

Carglumic acid; 1188-38-1; N-Carbamyl-L-glutamic acid; Carbaglu; N-Carbamoyl-L-glutamic acid; (2S)-2-(carbamoylamino)pentanedioic acid; Ureidoglutaric acid; Carbamylglutamic acid; Carbamino-L-glutamic acid; L-N-Carbamoylglutamic acid; acido carglumico; acide carglumique; L-Glutamic acid, N-(aminocarbonyl)-; DTXSID7046706; acidum carglumicum; 5L0HB4V1EW

GHS 危害分类

Reported hazard statements	H302 (100%), H315 (100%), H319 (100%), H335 (100%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

公开数据库对它的描述

N-carbamyl-L-glutamic acid · CAS 1188-38-1 · C6H10N2O5. UNII 5L0HB4V1EW. LogP: -1.097.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。