异噻唑啉酮（CAS 26172-55-4）：分子式 C4H4ClNOS、分子量 149.60。
| CAS号 | 26172-55-4 |
|---|---|
| 分子式 | C4H4ClNOS |
| 分子量 | 149.60 |
| 熔点 | 54-55 °C |
| LogP | log Kow = 0.401 at 24 °C |
| 应用领域 | Uses: CIR ingredient: Methylchloroisothiazolinone、Kathon preparations are used as preservatives in cosmetics and in many industrial applications: metalworking fluids、latex paints、adhesives、glues、developing solutions、and slime control agents in paper mills. [Marks、p. 102-4] Used as a preservative in leather processing、[PMID 21938525] Exposed workers include house painters、printers、housekeepers、and machinists.、Metal Machining [Category: Heat or Machine]、Semiconductor Manufacturing [Category: Industry]、Pulp and Paper Processing [Category: Industry]、Painting (Pigments、Binders、and Biocides) [Category: Paint]、Working with Glues and Adhesives [Category: Other]、Using Disinfectants or Biocides [Category: Clean]、Leather Tanning and Processing [Category: Industry]、Photographic Processing [Category: Other]、Dressing Hair [Category: Other]、Isothiazolinones are used as preservatives、biocides、and disinfectants.、Ceramics making [Category: Hobbies]、For 5-chloro-2-methyl-4-isothiazolin-3-one (USEPA、OPP Pesticide Code: 107103) ACTIVE products with label matches.、SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Antimicrobial preservative in cosmetics、hygiene products、paints、emulsions、cutting oils、paper coatings、and water storage and cooling units.、Used in hydraulic fracturing fluids、The "mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one with magnesium chloride and magnesium nitrate" is currently regulated as a preservative in the cosmetic directive (76、768、EEC) ... with the maximum authorized concentration 0.0015% (15 ppm) of the mixture ... It is the formulated product sold to customers for cosmetic applications ... it is a cosmetic preservative. The main uses are rinse-off products、such as shampoos、conditioners、gels and surfactants. The European Union use concentration is a maximum of 15 ppm a.i. for rinse-off and leave-on products. However、the manufacturers recommend a maximum level of 7.5 ppm a.i. (0.05% by weight of product as supplied) for leave-on products. The manufacturers recommend the mixuture as a preservative in shower gels、body washes、bubble baths、liquid soaps、shampoos、hair conditioners and wipes. The mixtures have wide applications in household (domestic) and industrial products.、Type of Pesticide: Microbiocide、Microbiostat (slime-forming bacteria、fungi、and algae)、Fungicide (mold and mildew、sapstain) ... Use sites: Wood Protection Treatment To Forest Products (Seasoned)、Wood Pressure Treatment To Forest Products、Oil Recovery Drilling Muds、Packer Fluids ... Commercial、Industrial Water Cooling Systems、Packer Fluids、Pulp、Paper Mill Water Systems、Secondary Oil Recovery Injection Water、Wood Protection Treatment、Adhesives、Industrial Coatings、Industrial Emulsions、Resin、Latex、Polymer ... Microbiocide for oil recovery drilling muds and packer fluids - 0.34 to 34 ppm active ingredient.、Use Classification: EPA Safer Chemical Functional Use Classes -> Preservatives and Antioxidants、Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class、but has some hazard profile issues、Cosmetics -> Preservative、Industry Uses: Preservative、Not Known or Reasonably Ascertainable、Consumer Uses: Preservative、Formulations、Preparations: All of the products containing MIT、Methylisothiazolinone、and MIT、CMIT、Chloromethyliosthiazolinone、are formulated as ready to use solutions、flowable concentrates and liquid soluble concentrates.、The National Pesticide Information Retrieval System (NPIRS) identifies 32 companies with active labels for products containing the chemical 5-chloro-2-methyl-3(2H)-isothiazolone. To view the complete list of companies、product names and percent 5-chloro-2-methyl-3(2H)-isothiazolone in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field.、Aeroset Water Bath Additive (Abbptt Laboratories): Active ingredient: 5-Chloro-2-methyl-3(2H)-isothiazolone 0.211%、2-Methyl-3(2H)-isothiazolone 0.075%.、Mergal Mitz (Troy Chemical Company Limited): Active ingredient: 5-Chloro-2-methyl-3(2H)-isothiazolone 1.1%、2-Methyl-3(2H)-isothiazolone 3.5%.、For more Formulations、Preparations (Complete) data for 5-Chloro-2-methyl-4-isothiazolin-3-one (27 total)、please visit the HSDB record page.、U.S. Production: 2023: <50、000 lb、2022: <50、2021: 50、000 - <250、2020: 50、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: 3(2H)-Isothiazolone、5-chloro-2-methyl-. National Production Volume: 4、965 lb、yr.、General Manufacturing Information: Furniture and Related Product Manufacturing、Adhesive Manufacturing、Paint and Coating Manufacturing、Plastics Material and Resin Manufacturing、Wood Product Manufacturing、Transportation Equipment Manufacturing、3(2H)-Isothiazolone、5-chloro-2-methyl-: ACTIVE、2-Methyl-3(2H)-isothiazolinone and 5-chloro-3-methyl-3(2H)-isothiazolinone occur together in 101 currently registered products in approximately a 3:1 ratio、and are commonly referred to collectively as methylisothiazolinone. |
登记用途：Uses: CIR ingredient: Methylchloroisothiazolinone、Kathon preparations are used as preservatives in cosmetics and in many industrial applications: metalworking fluids、latex paints、adhesives、glues、developing solutions、and slime control agents in paper mills. [Marks、p. 102-4] Used as a preservative in leather processing、[PMID 21938525] Exposed workers include house painters、printers、housekeepers、and machinists.、Metal Machining [Category: Heat or Machine]、Semiconductor Manufacturing [Category: Industry]、Pulp and Paper Processing [Category: Industry]、Painting (Pigments、Binders、and Biocides) [Category: Paint]、Working with Glues and Adhesives [Category: Other]、Using Disinfectants or Biocides [Category: Clean]、Leather Tanning and Processing [Category: Industry]、Photographic Processing [Category: Other]、Dressing Hair [Category: Other]、Isothiazolinones are used as preservatives、biocides、and disinfectants.、Ceramics making [Category: Hobbies]、For 5-chloro-2-methyl-4-isothiazolin-3-one (USEPA、OPP Pesticide Code: 107103) ACTIVE products with label matches.、SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Antimicrobial preservative in cosmetics、hygiene products、paints、emulsions、cutting oils、paper coatings、and water storage and cooling units.、Used in hydraulic fracturing fluids、The "mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one with magnesium chloride and magnesium nitrate" is currently regulated as a preservative in the cosmetic directive (76、768、EEC) ... with the maximum authorized concentration 0.0015% (15 ppm) of the mixture ... It is the formulated product sold to customers for cosmetic applications ... it is a cosmetic preservative. The main uses are rinse-off products、such as shampoos、conditioners、gels and surfactants. The European Union use concentration is a maximum of 15 ppm a.i. for rinse-off and leave-on products. However、the manufacturers recommend a maximum level of 7.5 ppm a.i. (0.05% by weight of product as supplied) for leave-on products. The manufacturers recommend the mixuture as a preservative in shower gels、body washes、bubble baths、liquid soaps、shampoos、hair conditioners and wipes. The mixtures have wide applications in household (domestic) and industrial products.、Type of Pesticide: Microbiocide、Microbiostat (slime-forming bacteria、fungi、and algae)、Fungicide (mold and mildew、sapstain) ... Use sites: Wood Protection Treatment To Forest Products (Seasoned)、Wood Pressure Treatment To Forest Products、Oil Recovery Drilling Muds、Packer Fluids ... Commercial、Industrial Water Cooling Systems、Packer Fluids、Pulp、Paper Mill Water Systems、Secondary Oil Recovery Injection Water、Wood Protection Treatment、Adhesives、Industrial Coatings、Industrial Emulsions、Resin、Latex、Polymer ... Microbiocide for oil recovery drilling muds and packer fluids - 0.34 to 34 ppm active ingredient.、Use Classification: EPA Safer Chemical Functional Use Classes -> Preservatives and Antioxidants、Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class、but has some hazard profile issues、Cosmetics -> Preservative、Industry Uses: Preservative、Not Known or Reasonably Ascertainable、Consumer Uses: Preservative、Formulations、Preparations: All of the products containing MIT、Methylisothiazolinone、and MIT、CMIT、Chloromethyliosthiazolinone、are formulated as ready to use solutions、flowable concentrates and liquid soluble concentrates.、The National Pesticide Information Retrieval System (NPIRS) identifies 32 companies with active labels for products containing the chemical 5-chloro-2-methyl-3(2H)-isothiazolone. To view the complete list of companies、product names and percent 5-chloro-2-methyl-3(2H)-isothiazolone in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field.、Aeroset Water Bath Additive (Abbptt Laboratories): Active ingredient: 5-Chloro-2-methyl-3(2H)-isothiazolone 0.211%、2-Methyl-3(2H)-isothiazolone 0.075%.、Mergal Mitz (Troy Chemical Company Limited): Active ingredient: 5-Chloro-2-methyl-3(2H)-isothiazolone 1.1%、2-Methyl-3(2H)-isothiazolone 3.5%.、For more Formulations、Preparations (Complete) data for 5-Chloro-2-methyl-4-isothiazolin-3-one (27 total)、please visit the HSDB record page.、U.S. Production: 2023: <50、000 lb、2022: <50、2021: 50、000 - <250、2020: 50、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: 3(2H)-Isothiazolone、5-chloro-2-methyl-. National Production Volume: 4、965 lb、yr.、General Manufacturing Information: Furniture and Related Product Manufacturing、Adhesive Manufacturing、Paint and Coating Manufacturing、Plastics Material and Resin Manufacturing、Wood Product Manufacturing、Transportation Equipment Manufacturing、3(2H)-Isothiazolone、5-chloro-2-methyl-: ACTIVE、2-Methyl-3(2H)-isothiazolinone and 5-chloro-3-methyl-3(2H)-isothiazolinone occur together in 101 currently registered products in approximately a 3:1 ratio、and are commonly referred to collectively as methylisothiazolinone.。
异噻唑啉酮 是一种化工化合物，登记 CAS 号为 26172-55-4，分子式 C4H4ClNOS（分子量 149.60）。
登记 CAS 号：26172-55-4
其分子式 C4H4ClNOS 由 4 个碳、4 个氢、1 个氯、1 个氮、1 个氧、1 个硫 组成。
别名/同义词：异噻唑啉酮 · Methylchloroisothiazolinone
异噻唑啉酮 的 CAS 登记号为 26172-55-4。
分子式 C4H4ClNOS，分子量 149.60。
别名/同义词：异噻唑啉酮、Methylchloroisothiazolinone。
登记用途：Uses: CIR ingredient: Methylchloroisothiazolinone、Kathon preparations are used as preservatives in cosmetics and in many industrial applications: metalworking fluids、latex paints、adhesives、glues、developing solutions、and slime control agents in paper mills. [Marks、p. 102-4] Used as a preservative in leather processing、[PMID 21938525] Exposed workers include house painters、printers、housekeepers、and machinists.、Metal Machining [Category: Heat or Machine]、Semiconductor Manufacturing [Category: Industry]、Pulp and Paper Processing [Category: Industry]、Painting (Pigments、Binders、and Biocides) [Category: Paint]、Working with Glues and Adhesives [Category: Other]、Using Disinfectants or Biocides [Category: Clean]、Leather Tanning and Processing [Category: Industry]、Photographic Processing [Category: Other]、Dressing Hair [Category: Other]、Isothiazolinones are used as preservatives、biocides、and disinfectants.、Ceramics making [Category: Hobbies]、For 5-chloro-2-methyl-4-isothiazolin-3-one (USEPA、OPP Pesticide Code: 107103) ACTIVE products with label matches.、SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal、state and local authorities must be consulted for currently approved uses.、Antimicrobial preservative in cosmetics、hygiene products、paints、emulsions、cutting oils、paper coatings、and water storage and cooling units.、Used in hydraulic fracturing fluids、The "mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one with magnesium chloride and magnesium nitrate" is currently regulated as a preservative in the cosmetic directive (76、768、EEC) ... with the maximum authorized concentration 0.0015% (15 ppm) of the mixture ... It is the formulated product sold to customers for cosmetic applications ... it is a cosmetic preservative. The main uses are rinse-off products、such as shampoos、conditioners、gels and surfactants. The European Union use concentration is a maximum of 15 ppm a.i. for rinse-off and leave-on products. However、the manufacturers recommend a maximum level of 7.5 ppm a.i. (0.05% by weight of product as supplied) for leave-on products. The manufacturers recommend the mixuture as a preservative in shower gels、body washes、bubble baths、liquid soaps、shampoos、hair conditioners and wipes. The mixtures have wide applications in household (domestic) and industrial products.、Type of Pesticide: Microbiocide、Microbiostat (slime-forming bacteria、fungi、and algae)、Fungicide (mold and mildew、sapstain) ... Use sites: Wood Protection Treatment To Forest Products (Seasoned)、Wood Pressure Treatment To Forest Products、Oil Recovery Drilling Muds、Packer Fluids ... Commercial、Industrial Water Cooling Systems、Packer Fluids、Pulp、Paper Mill Water Systems、Secondary Oil Recovery Injection Water、Wood Protection Treatment、Adhesives、Industrial Coatings、Industrial Emulsions、Resin、Latex、Polymer ... Microbiocide for oil recovery drilling muds and packer fluids - 0.34 to 34 ppm active ingredient.、Use Classification: EPA Safer Chemical Functional Use Classes -> Preservatives and Antioxidants、Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class、but has some hazard profile issues、Cosmetics -> Preservative、Industry Uses: Preservative、Not Known or Reasonably Ascertainable、Consumer Uses: Preservative、Formulations、Preparations: All of the products containing MIT、Methylisothiazolinone、and MIT、CMIT、Chloromethyliosthiazolinone、are formulated as ready to use solutions、flowable concentrates and liquid soluble concentrates.、The National Pesticide Information Retrieval System (NPIRS) identifies 32 companies with active labels for products containing the chemical 5-chloro-2-methyl-3(2H)-isothiazolone. To view the complete list of companies、product names and percent 5-chloro-2-methyl-3(2H)-isothiazolone in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field.、Aeroset Water Bath Additive (Abbptt Laboratories): Active ingredient: 5-Chloro-2-methyl-3(2H)-isothiazolone 0.211%、2-Methyl-3(2H)-isothiazolone 0.075%.、Mergal Mitz (Troy Chemical Company Limited): Active ingredient: 5-Chloro-2-methyl-3(2H)-isothiazolone 1.1%、2-Methyl-3(2H)-isothiazolone 3.5%.、For more Formulations、Preparations (Complete) data for 5-Chloro-2-methyl-4-isothiazolin-3-one (27 total)、please visit the HSDB record page.、U.S. Production: 2023: <50、000 lb、2022: <50、2021: 50、000 - <250、2020: 50、Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: 3(2H)-Isothiazolone、5-chloro-2-methyl-. National Production Volume: 4、965 lb、yr.、General Manufacturing Information: Furniture and Related Product Manufacturing、Adhesive Manufacturing、Paint and Coating Manufacturing、Plastics Material and Resin Manufacturing、Wood Product Manufacturing、Transportation Equipment Manufacturing、3(2H)-Isothiazolone、5-chloro-2-methyl-: ACTIVE、2-Methyl-3(2H)-isothiazolinone and 5-chloro-3-methyl-3(2H)-isothiazolinone occur together in 101 currently registered products in approximately a 3:1 ratio、and are commonly referred to collectively as methylisothiazolinone.。
异噻唑啉酮（CAS 26172-55-4）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 26172-55-4 |
|---|---|
| PubChem CID | 33344 |
| Molecular formula | C4H4ClNOS |
| Molecular weight | 148.97 g/mol |
| IUPAC name | 5-chloro-2-methyl-1,2-thiazol-3-one |
| InChIKey | DHNRXBZYEKSXIM-UHFFFAOYSA-N |
| UNII (FDA) | DEL7T5QRPN |
| ChEBI ID | CHEBI:53621 |
| Molecular Weight | 149.60 |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 148.9702126 |
| Monoisotopic Mass | 148.9702126 |
| Topological Polar Surface Area | 45.6 |
| Heavy Atom Count | 8 |
| Melting Point | 54-55 °C |
|---|---|
| Solubility | In water, 706-751 g/L at 20 °C |
| Vapor Pressure | 0.018 mm Hg at 25 °C |
| LogP | log Kow = 0.401 at 24 °C |
5-Chloro-2-methyl-4-isothiazolin-3-one; 26172-55-4; Methylchloroisothiazolinone; CMIT; 5-Chloro-2-methyl-3(2H)-isothiazolone; 5-Chloro-2-methyl-3-isothiazolone; Kathon CG 5243; 3(2H)-Isothiazolone, 5-chloro-2-methyl-; 5-chloro-N-methylisothiazolone; 5-chloro-2-methylisothiazolin-3-one; 5-chloro-n-methylisothiazolin-3-one; HS 818; n-methyl-5-chloroisothiazolone; DEL7T5QRPN; DTXSID9034286; 4-ISOTHIAZOLIN-3-ONE, 5-CHLORO-2-METHYL-
| Regulatory & Food Contact | FDA Cumulative Estimated Daily Intake (CEDI): FCS FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS CIR / INCI: Cosmetic ingredients (Methylchloroisothiazolinone) -> CIR (Cosmetic Ingredient Review) CIR / INCI: Preservative |
|---|---|
| GHS notification summary | 1.3% (31 / 2393) |
| GHS notification summary | 1.3% (31 / 2393) |
|---|---|
| Reported hazard statements | H300 (20.2%), H301, H311 (24%), H310 (31.2%), H314 (98.3%), H317 (98.4%), H318 (64.9%), H330 (38.7%) |
This chemical does not meet GHS hazard criteria for 1.3% (31 of 2393) of reports.
H300 (20.2%): Fatal if swallowed [Danger Acute toxicity, oral]
Methylchloroisothiazolinone is identified by CAS 26172-55-4, molecular formula C4H4ClNOS and molecular weight 148.97 g/mol. UNII DEL7T5QRPN; ChEBI 53621; InChIKey DHNRXBZYEKSXIM-UHFFFAOYSA-N. Melting Point: 54-55 °C; Solubility: In water, 706-751 g/L at 20 °C; Vapor Pressure: 0.018 mm Hg at 25 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Methylchloroisothiazolinone