山楂酸（CAS 4373-41-5）：分子式 C30H48O4、分子量 472.7。
| CAS号 | 4373-41-5 |
|---|---|
| 分子式 | C30H48O4 |
| 分子量 | 472.7 |
| 熔点 | 249 - 250 °C |
| LogP | 6.5 |
| 应用领域 | Uses: Maslinic acid is reported to have potent antioxidant、anti-cancer、anti-HIV and anti-inflammatory activities、Maslinic acid is a protease inhibitor that、among other features、has the capacity of regulating cell growth. It is useful for cancer treatment、as it allows to control the hyperplasia and hypertrophy processes、typical of this disease.、... investigated the mechanisms of maslinic acid with regard to its inhibitory effects on the growth of HT29 colon-cancer cells. High concentrations of maslinic acid are present in the protective wax-like coating of olives. Our results show that treatment with maslinic acid results in a significant inhibition of cell proliferation in a dose-dependent manner and causes apoptotic death in colon-cancer cells. We found that it inhibits considerably the expression of Bcl-2 whilst increasing that of Bax、it also stimulates the release of mitochondrial cytochrome-c and activates caspase-9 and caspase-3. All these results point clearly to the activation of the mitochondrial apoptotic pathway in response to the treatment of HT29 colon-cancer cells with maslinic acid. Our results suggest that maslinic acid has the potential to provide significant natural defence against colon-cancer.、Maslinic acid has multiple biological and antimicrobial activities including anti-malarial activity、For more Uses (Complete) data for Maslinic Acid (6 total)、please visit the HSDB record page.、General Manufacturing Information: ... Interest for maslinic acid has increased because of its beneficial effects on health、which include antitumoral、antidiabetic、and antioxidant activities. Moreover、it has been attributed to anti-HIV and antiparasitic effects as well as vasorelaxant and stimulant of growth and protein-turnover properties.、Malinic acid is available as a dietary supplement as being a strong antioxidant and natural anti-inflammatory、available in consumer products such as olive oil、high protein fiber bars and skin care lotion products |
登记用途：Uses: Maslinic acid is reported to have potent antioxidant、anti-cancer、anti-HIV and anti-inflammatory activities、Maslinic acid is a protease inhibitor that、among other features、has the capacity of regulating cell growth. It is useful for cancer treatment、as it allows to control the hyperplasia and hypertrophy processes、typical of this disease.、... investigated the mechanisms of maslinic acid with regard to its inhibitory effects on the growth of HT29 colon-cancer cells. High concentrations of maslinic acid are present in the protective wax-like coating of olives. Our results show that treatment with maslinic acid results in a significant inhibition of cell proliferation in a dose-dependent manner and causes apoptotic death in colon-cancer cells. We found that it inhibits considerably the expression of Bcl-2 whilst increasing that of Bax、it also stimulates the release of mitochondrial cytochrome-c and activates caspase-9 and caspase-3. All these results point clearly to the activation of the mitochondrial apoptotic pathway in response to the treatment of HT29 colon-cancer cells with maslinic acid. Our results suggest that maslinic acid has the potential to provide significant natural defence against colon-cancer.、Maslinic acid has multiple biological and antimicrobial activities including anti-malarial activity、For more Uses (Complete) data for Maslinic Acid (6 total)、please visit the HSDB record page.、General Manufacturing Information: ... Interest for maslinic acid has increased because of its beneficial effects on health、which include antitumoral、antidiabetic、and antioxidant activities. Moreover、it has been attributed to anti-HIV and antiparasitic effects as well as vasorelaxant and stimulant of growth and protein-turnover properties.、Malinic acid is available as a dietary supplement as being a strong antioxidant and natural anti-inflammatory、available in consumer products such as olive oil、high protein fiber bars and skin care lotion products。
山楂酸 是一种化工化合物，登记 CAS 号为 4373-41-5，分子式 C30H48O4（分子量 472.7）。
登记 CAS 号：4373-41-5
其分子式 C30H48O4 由 30 个碳、48 个氢、4 个氧 组成。
别名/同义词：山楂酸 · Maslinic acid
山楂酸 的 CAS 登记号为 4373-41-5。
分子式 C30H48O4，分子量 472.7。
别名/同义词：山楂酸、Maslinic acid。
登记用途：Uses: Maslinic acid is reported to have potent antioxidant、anti-cancer、anti-HIV and anti-inflammatory activities、Maslinic acid is a protease inhibitor that、among other features、has the capacity of regulating cell growth. It is useful for cancer treatment、as it allows to control the hyperplasia and hypertrophy processes、typical of this disease.、... investigated the mechanisms of maslinic acid with regard to its inhibitory effects on the growth of HT29 colon-cancer cells. High concentrations of maslinic acid are present in the protective wax-like coating of olives. Our results show that treatment with maslinic acid results in a significant inhibition of cell proliferation in a dose-dependent manner and causes apoptotic death in colon-cancer cells. We found that it inhibits considerably the expression of Bcl-2 whilst increasing that of Bax、it also stimulates the release of mitochondrial cytochrome-c and activates caspase-9 and caspase-3. All these results point clearly to the activation of the mitochondrial apoptotic pathway in response to the treatment of HT29 colon-cancer cells with maslinic acid. Our results suggest that maslinic acid has the potential to provide significant natural defence against colon-cancer.、Maslinic acid has multiple biological and antimicrobial activities including anti-malarial activity、For more Uses (Complete) data for Maslinic Acid (6 total)、please visit the HSDB record page.、General Manufacturing Information: ... Interest for maslinic acid has increased because of its beneficial effects on health、which include antitumoral、antidiabetic、and antioxidant activities. Moreover、it has been attributed to anti-HIV and antiparasitic effects as well as vasorelaxant and stimulant of growth and protein-turnover properties.、Malinic acid is available as a dietary supplement as being a strong antioxidant and natural anti-inflammatory、available in consumer products such as olive oil、high protein fiber bars and skin care lotion products。
山楂酸（CAS 4373-41-5）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 4373-41-5 |
|---|---|
| PubChem CID | 73659 |
| Molecular formula | C30H48O4 |
| IUPAC name | (4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
| UNII (FDA) | E233J88OHQ |
| Molecular Weight | 472.7 |
|---|---|
| XLogP3 | 6.5 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 1 |
| Exact Mass | 472.35526001 |
| Monoisotopic Mass | 472.35526001 |
| Topological Polar Surface Area | 77.8 |
| Heavy Atom Count | 34 |
| Melting Point | 249 - 250 °C |
|---|---|
| Density | 1.15 g/cu cm |
Maslinic acid; 4373-41-5; Crategolic acid; Crataegolic acid; Maslic acid; Masilinic acid; 2alpha-hydroxyoleanolic acid; E233J88OHQ; 2alpha,3beta-dihydroxyurs-12-en-29-oic acid; CHEBI:66682; DTXSID30905074; 2-hydroxyoleanolic acid; Olean-12-en-28-oic acid, 2,3-dihydroxy-, (2alpha,3beta)-; RefChem:41765; (2alpha, 3beta)-2,3-dihydroxyolean-12-en-28-oic acid; (2beta, 3alpha)-2,3-dihydroxyolean-12-en-28-oic acid
Maslinic acid · CAS 4373-41-5 · C30H48O4. UNII E233J88OHQ. Melting Point: 249 - 250 °C; Density: 1.15 g/cu cm.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Maslinic acid