Levofloxacin

Description

Levofloxacin · CAS 100986-85-4 · C18H20FN3O4. UNII RIX4E89Y14. Melting Point: 225-227C; Melting Point: 225-227 °C (decomposes); LogP: 2.1.

Identification

CAS Registry Number	100986-85-4
PubChem CID	149096
Molecular formula	C18H20FN3O4
IUPAC name	(2S)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
UNII (FDA)	RIX4E89Y14

Computed Descriptors

Molecular Weight	361.4
XLogP3	-0.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Exact Mass	361.14378429
Monoisotopic Mass	361.14378429
Topological Polar Surface Area	73.3
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	225-227C
Melting Point	225-227 °C (decomposes)
LogP	2.1
LogP	log Kow = -0.39
Dissociation Constants	8.12
Dissociation Constants	6.1
Dissociation Constants	8.6
Dissociation Constants	6.25

Physical description & handling notes

• Solid
• Light yellowish -white to yellow-white crystal or crystalline powder
• Needles from ethanol + ethyl ether
• Sparingly soluble
• Freely soluble in glacial acetic acid, chloroform; sparingly soluble in water
• >54.2 [ug/mL] (The mean of the results at pH 7.4)

GHS Hazard Classification

Reported hazard statements	H302 (98.3%), H317 (96%), H334 (97.1%), H361 (54.6%), H362 (53.4%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >7500
• Use (kg; exact) in Germany (2009): 7956
• Consumption (g per capita; approx.) in Germany (2009): 0.0916
• Consumption (g per capita; exact) in Germany (2009): 0.0972
• Consumption (g per capita) in the USA (2002): 0.16
• For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium</i> species, <i>Staphylococus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Streptococcus pneumoniae</i>, <i>Streptococcus</i> (Groups C/F/G), Viridans group streptococci, <i>Acinetobacter lwoffii</i>, <i>Haemophilus influenzae</i>, <i>Serratia marcescens</i>. Levofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening bacterial infection (L1009).

Synonyms

LEVOFLOXACIN; 100986-85-4; Levaquin; Quixin; (-)-Ofloxacin; Iquix; Cravit; (S)-Ofloxacin; Levofloxacine; Tavanic; Levofloxacino; Levofloxacinum; Elequine; Oftaquix; L-Ofloxacin; Floxacin

Frequently Asked Questions

What are the CAS number and molecular formula of Levofloxacin?

CAS 100986-85-4; molecular formula C18H20FN3O4; molecular weight — g/mol.

What other names is Levofloxacin known by?

LEVOFLOXACIN, 100986-85-4, Levaquin, Quixin, (-)-Ofloxacin, Iquix.

Is Levofloxacin classified as hazardous?

Hazard statements reported: H302, H317, H334, H361, H362.

What are the key physical properties of Levofloxacin?

Melting Point: 225-227C; Melting Point: 225-227 °C (decomposes); LogP: 2.1; LogP: log Kow = -0.39.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.