Lefunomide

Description

Lefunomide · CAS 75706-12-6 · C12H9F3N2O2. UNII G162GK9U4W. Melting Point: 165-166 °C; Melting Point: 166.5 °C; Melting Point: 165 - 166 °C.

Identification

CAS Registry Number	75706-12-6
PubChem CID	3899
Molecular formula	C12H9F3N2O2
IUPAC name	5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
UNII (FDA)	G162GK9U4W

Computed Descriptors

Molecular Weight	270.21
XLogP3	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	270.06161202
Monoisotopic Mass	270.06161202
Topological Polar Surface Area	55.1
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Melting Point	165-166 °C
Melting Point	166.5 °C
Melting Point	165 - 166 °C
Solubility	21
Solubility	8.44e-02 g/L
LogP	2.8
LogP	3.9

Physical description & handling notes

• Solid
• Crystals from toluene
• In water, 153 mg/L at 25 °C /Estimated/
• 1.25X10-6 mm Hg at 25 °C /Estimated/
• log Kow = 2.43 /Estimated/
• Henry's Law constant = 1.23X10-10 atm-cu m/mol at 25 °C /Estimated/

GHS Hazard Classification

Reported hazard statements	H301 (99.3%), H315 (96.3%), H319 (96.3%), H335 (96.3%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Use (kg; exact) in Germany (2009): 274
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita; exact) in Germany (2009): 0.00334
• Consumption (g per capita) in the USA (2002): 0.000783
• Preparation: F.J. Kaemmerer, R. Schleyerbach, DE 2854439; eidem, US 4284786 (1980, 1981 both to Hoechst)

Synonyms

leflunomide; 75706-12-6; Arava; Leflunomida; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomidum; HWA-486; Repso; leflunomide medac; SU101; Leflunomide teva; 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; SU-101; DTXSID9023201; Leflunomide winthrop; SULOL

Frequently Asked Questions

What are the CAS number and molecular formula of Lefunomide?

CAS 75706-12-6; molecular formula C12H9F3N2O2; molecular weight — g/mol.

What other names is Lefunomide known by?

leflunomide, 75706-12-6, Arava, Leflunomida, 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide, Leflunomidum.

Is Lefunomide classified as hazardous?

Hazard statements reported: H301, H315, H319, H335.

What are the key physical properties of Lefunomide?

Melting Point: 165-166 °C; Melting Point: 166.5 °C; Melting Point: 165 - 166 °C; Solubility: 21.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.