Lefunomide（CAS 75706-12-6）：分子式 C12H9F3N2O2、分子量 270.21；类别 有机化学品。
| CAS号 | 75706-12-6 |
|---|---|
| 分子式 | C12H9F3N2O2 |
| 分子量 | 270.21 |
| 熔点 | 165-166 °C |
| LogP | 2.8 |
| 应用领域 | Uses: Medication: antirheumatic、Use (kg、approx.) in Germany (2009): >250、exact) in Germany (2009): 274、Use (kg) in USA (2002): 221、Consumption (g per capita、approx.) in Germany (2009): 0.00305、exact) in Germany (2009): 0.00334、Consumption (g per capita) in the USA (2002): 0.000783、Calculated removal (%): 10.4、Formulations、Preparations: Oral: Tablets 10 mg Arava (Aventis)、20 mg Arava (Aventis)、100 mg Arava (Aventis).、General Manufacturing Information: Preparation: F.J. Kaemmerer、R. Schleyerbach、DE 2854439、eidem、US 4284786 (1980、1981 both to Hoechst)、Information available in 2004 indicated that Leflunomide was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Colombia、Costa Rica、Croatia、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Hong Kong、Hungary、India、Indonesia、Ireland、Israel、Italy、Japan、Malaysia、Mexico、Netherlands、Norway、New Zealand、Panama、Portugal、Romania、Singapore、Slovenia、South Africa、Spain、Sweden、Switzerland、Thailand、United Kingdom、USA、Yugoslavia (1、2) |
| 类别 | Organic Chemicals |
登记用途：Uses: Medication: antirheumatic、Use (kg、approx.) in Germany (2009): >250、exact) in Germany (2009): 274、Use (kg) in USA (2002): 221、Consumption (g per capita、approx.) in Germany (2009): 0.00305、exact) in Germany (2009): 0.00334、Consumption (g per capita) in the USA (2002): 0.000783、Calculated removal (%): 10.4、Formulations、Preparations: Oral: Tablets 10 mg Arava (Aventis)、20 mg Arava (Aventis)、100 mg Arava (Aventis).、General Manufacturing Information: Preparation: F.J. Kaemmerer、R. Schleyerbach、DE 2854439、eidem、US 4284786 (1980、1981 both to Hoechst)、Information available in 2004 indicated that Leflunomide was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Colombia、Costa Rica、Croatia、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Hong Kong、Hungary、India、Indonesia、Ireland、Israel、Italy、Japan、Malaysia、Mexico、Netherlands、Norway、New Zealand、Panama、Portugal、Romania、Singapore、Slovenia、South Africa、Spain、Sweden、Switzerland、Thailand、United Kingdom、USA、Yugoslavia (1、2)。
Lefunomide 是一种以碳骨架为基础的有机化合物，登记 CAS 号为 75706-12-6，分子式 C12H9F3N2O2（分子量 270.21），归属于有机化学品大类化工原料。
登记 CAS 号：75706-12-6
其分子式 C12H9F3N2O2 由 12 个碳、9 个氢、3 个氟、2 个氮、2 个氧 组成。
别名/同义词：Lefunomide · leflunomide
所属分类：有机化学品
Lefunomide 的 CAS 登记号为 75706-12-6。
分子式 C12H9F3N2O2，分子量 270.21。
别名/同义词：Lefunomide、leflunomide。
登记用途：Uses: Medication: antirheumatic、Use (kg、approx.) in Germany (2009): >250、exact) in Germany (2009): 274、Use (kg) in USA (2002): 221、Consumption (g per capita、approx.) in Germany (2009): 0.00305、exact) in Germany (2009): 0.00334、Consumption (g per capita) in the USA (2002): 0.000783、Calculated removal (%): 10.4、Formulations、Preparations: Oral: Tablets 10 mg Arava (Aventis)、20 mg Arava (Aventis)、100 mg Arava (Aventis).、General Manufacturing Information: Preparation: F.J. Kaemmerer、R. Schleyerbach、DE 2854439、eidem、US 4284786 (1980、1981 both to Hoechst)、Information available in 2004 indicated that Leflunomide was used in the manufacture of pharmaceutical preparations in the following countries: Algeria、Argentina、Australia、Austria、Belgium、Brazil、Canada、Chile、Colombia、Costa Rica、Croatia、Czech Republic、Denmark、Dominican Republic、Ecuador、El Salvador、Finland、France、Germany、Greece、Guatemala、Hong Kong、Hungary、India、Indonesia、Ireland、Israel、Italy、Japan、Malaysia、Mexico、Netherlands、Norway、New Zealand、Panama、Portugal、Romania、Singapore、Slovenia、South Africa、Spain、Sweden、Switzerland、Thailand、United Kingdom、USA、Yugoslavia (1、2)。
所属分类：Organic Chemicals。
Lefunomide（CAS 75706-12-6）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 75706-12-6 |
|---|---|
| PubChem CID | 3899 |
| Molecular formula | C12H9F3N2O2 |
| IUPAC name | 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide |
| UNII (FDA) | G162GK9U4W |
| Molecular Weight | 270.21 |
|---|---|
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 2 |
| Exact Mass | 270.06161202 |
| Monoisotopic Mass | 270.06161202 |
| Topological Polar Surface Area | 55.1 |
| Heavy Atom Count | 19 |
| Melting Point | 165-166 °C |
|---|---|
| Melting Point | 166.5 °C |
| Melting Point | 165 - 166 °C |
| Solubility | 21 |
| Solubility | 8.44e-02 g/L |
| LogP | 2.8 |
| LogP | 3.9 |
leflunomide; 75706-12-6; Arava; Leflunomida; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomidum; HWA-486; Repso; leflunomide medac; SU101; Leflunomide teva; 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; SU-101; DTXSID9023201; Leflunomide winthrop; SULOL
| Reported hazard statements | H301 (99.3%), H315 (96.3%), H319 (96.3%), H335 (96.3%) |
|---|
H301 (99.3%): Toxic if swallowed [Danger Acute toxicity, oral]
H315 (96.3%): Causes skin irritation [Warning Skin corrosion/irritation]
Lefunomide · CAS 75706-12-6 · C12H9F3N2O2. UNII G162GK9U4W. Melting Point: 165-166 °C; Melting Point: 166.5 °C; Melting Point: 165 - 166 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Lefunomide