Isosorbide

Description

Isosorbide is identified by CAS 652-67-5, molecular formula C6H10O4 and molecular weight 146.06 g/mol. UNII WXR179L51S; ChEBI 6060; InChIKey KLDXJTOLSGUMSJ-JGWLITMVSA-N. Boiling Point: 175; Melting Point: 60-63; Melting Point: 61-64 °C.

Identification

CAS Registry Number	652-67-5
PubChem CID	12597
Molecular formula	C6H10O4
Molecular weight	146.06 g/mol
IUPAC name	(3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
InChIKey	KLDXJTOLSGUMSJ-JGWLITMVSA-N
UNII (FDA)	WXR179L51S
ChEBI ID	CHEBI:6060

Computed Descriptors

Molecular Weight	146.14
XLogP3	-1.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	146.05790880
Monoisotopic Mass	146.05790880
Topological Polar Surface Area	58.9
Heavy Atom Count	10
Formal Charge	0

Physical & Chemical Properties

Boiling Point	175
Melting Point	60-63
Melting Point	61-64 °C
Solubility	29

Physical description & handling notes

• Liquid; Dry Powder; Liquid
• CRYSTALS
• SPECIFIC OPTICAL ROTATION: +44 DEG/D
• Isosorbide reduces intraocular pressure through its effects on ocular blood vessels. While in the blood, isosorbide promotes redistribution of water toward the circulation, promoting the excretion of urine.
• ISMOTIC (ALCON), ORAL AS 45% SOLUTION.

Regulatory Status

Regulatory & Food Contact	FDA Cumulative Estimated Daily Intake (CEDI): FCS
GHS notification summary	99.3% (145 / 146)

GHS Hazard Classification

GHS notification summary	99.3% (145 / 146)

Documented Uses

• Not Known or Reasonably Ascertainable
• PREPARED BY ACID DEHYDRATION OF D-GLUCITOL: HAWORTH, WIGGINS, BRITISH PATENT 600,870 (1948). PURIFICATION: HARTMANN, US PATENT 3,160,641 (1964 TO ATLAS CHEM INDUSTRIES).
• Plastics Material and Resin Manufacturing
• D-Glucitol, 1,4:3,6-dianhydro-: ACTIVE
• A POLYOL WITH HYDROXYL GROUP ATTACHED TO EACH OF TWO CIS-ORIENTED SATURATED FURAN RINGS.
• Isosorbide was previously indicated for temporary reduction of intraocular pressure and used to interrupt an acute glaucoma attack, however, this is not a currently approved indication. Refer to [isosorbide mononitrate] and [isosorbide dinitrate] drug entries for more isosorbide indications.

Synonyms

isosorbide; 652-67-5; Isobide; Devicoran; 1,4:3,6-Dianhydro-D-glucitol; Hydronol; Ismotic; (3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol; (+)-D-Isosorbide; D-Glucitol, 1,4:3,6-dianhydro-; 1,4:3,6-Dianhydro-D-sorbitol; 1,4:3,6-Dianhydrosorbitol; DTXSID5046196; NSC-40725; Glucitol, 1,4:3,6-dianhydro-, D-; WXR179L51S

Frequently Asked Questions

What are the CAS number and molecular formula of Isosorbide?

CAS 652-67-5; molecular formula C6H10O4; molecular weight 146.06 g/mol.

What other names is Isosorbide known by?

isosorbide, 652-67-5, Isobide, Devicoran, 1,4:3,6-Dianhydro-D-glucitol, Hydronol.

What is the regulatory status of Isosorbide?

Documented regulatory listings: FDA Cumulative Estimated Daily Intake (CEDI): FCS.

Is Isosorbide classified as hazardous?

99.3% of GHS notifications report no hazard classification (145 of 146).

What are the key physical properties of Isosorbide?

Boiling Point: 175; Melting Point: 60-63; Melting Point: 61-64 °C; Solubility: 29.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.