Insulin

Description

Insulin · CAS 9004-10-8 · C256H381N65O77S6. pH: 2.5-3.5.

Identification

CAS Registry Number	9004-10-8
PubChem CID	70678557
Molecular formula	C256H381N65O77S6

Computed Descriptors

Molecular Weight	5794
XLogP3	-12.8
Hydrogen Bond Donor Count	78
Hydrogen Bond Acceptor Count	89
Rotatable Bond Count	178
Exact Mass	5791.6287098
Monoisotopic Mass	5789.6220002
Topological Polar Surface Area	2450
Heavy Atom Count	404
Formal Charge	0

Physical & Chemical Properties

pH	2.5-3.5

Physical description & handling notes

• Solid; [Merck Index]
• COLORLESS OR ALMOST COLORLESS IF CONTAINING NOT MORE THAN 100 USP UNITS/ML; STRAW-COLORED IF CONTAINING 500 UNITS
• CRYSTALS HEXAGONAL SYSTEM, USUALLY OBTAINED AS FLAT RHOMBOHEDRA & CONTAINING 0.4% ZINC
• READILY SOL IN DILUTE ACIDS; SOL IN WATER
• READILY SOL IN ALKALIES; PRACTICALLY INSOL FROM PH 4.5-7.0; CRYSTALS CONTAINING 2% ZN @ PH 7 ARE MUCH LESS SOL
• SHOULD BE STORED AT 2 TO 8 °C & SHOULD NOT BE SUBJECTED TO FREEZING OR EXTREMES IN TEMP

Regulatory Status

GHS notification summary	99.1% (116 / 117)

GHS Hazard Classification

GHS notification summary	99.1% (116 / 117)

Documented Uses

• Hormone of carbohydrate and lipid metabolism that is used to treat diabetes; [Merck Index]
• Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• EXTRACTION OF THE PANCREAS OF SLAUGHTERED ANIMALS WITH ACIDIFIED DILUTE ALCOHOL, FOLLOWED BY PRECIPITATION WITH ABSOLUTE ALCOHOL, REDISSOLUTION, PRECIPITATION WITH ZINC CHLORIDE, & REDISSOLUTION IN WATER
• SYNTHESIS OF HUMAN INSULIN: KATSOYAMIS ET AL, J AM CHEM SOC 88, 164, 166 (1966); RUTTENBERG, SCIENCE 177, 623 (1972) (FROM PORCINE INSULIN). ... APPROACHES TO COMMERCIAL SYNTHESIS: CHEM & ENG NEWS 52, 19 (APRIL 29, 1974).
• BY USE OF PORCINE INSULIN AS STARTING MATERIAL, HUMAN INSULIN CAN NOW BE SYNTHESIZED WITH RELATIVE EASE.

Synonyms

9004-10-8; Endopancrine; Decurvon; Dermulin; Insular; Insulyl; Iszilin; Musulin; Iletin; Intesulin B; Insulina dalanatada; Insulinum dalanatum; AERx; INSULIN INJECTION; Insulina iniettabile neutra; Insulini injectio neutralis

Frequently Asked Questions

What are the CAS number and molecular formula of Insulin?

CAS 9004-10-8; molecular formula C256H381N65O77S6; molecular weight — g/mol.

What other names is Insulin known by?

9004-10-8, Endopancrine, Decurvon, Dermulin, Insular, Insulyl.

Is Insulin classified as hazardous?

99.1% of GHS notifications report no hazard classification (116 of 117).

What are the key physical properties of Insulin?

pH: 2.5-3.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.