消炎痛（CAS 53-86-1）：分子式 C19H16ClNO4、分子量 357.8。
| CAS号 | 53-86-1 |
|---|---|
| 分子式 | C19H16ClNO4 |
| 分子量 | 357.8 |
| 熔点 | 311 or 323.6 °F (NTP, 1992) |
| LogP | 4.27 |
| 应用领域 | Uses: MEDICATION、Anti-Inflammatory Agents、Non-Steroidal、Cardiovascular Agents、Cyclooxygenase Inhibitors、Gout Suppressants、Tocolytic Agents、Use (kg) in Switzerland (2009): >100、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 4630、Consumption (g per capita) in Switzerland (2009): 0.013、Consumption (g per capita、approx.) in Germany (2009): 0.012、Consumption (g per capita) in the USA (2002): 0.016、Excretion rate: 0.275、Calculated removal (%): 78.5、For moderate to severe rheumatoid arthritis including acute flares of chronic disease、ankylosing spondylitis、osteoarthritis、acute painful shoulder (bursitis and、or tendinitis) and acute gouty arthritis.、Use Classification: Pharmaceuticals、Methods of Manufacturing: p-Anisidine + ethyl levulinate + p-chlorobenzoyl chloride (diazotisation、hydrogenation、Fischer indole synthesis、amide formation、saponification).、Acylation of sodium 2-(4-methoxy-phenyl)hydrazine-1-sulfonate with 4-chlorobenzoyl chloride followed by heating yields 1-(4- chlorobenzoyl)-1-(4-methoxyphenyl)hydrazine. Condensation with levulinic acid in a Fischer indole synthesis affords indomethacin.、Formulations、Preparations: Table: Indomethacin Preparations [Table#4437]、Table: Indomethacin Sodium Preparations [Table#4438]、General Manufacturing Information: 1H-Indole-3-acetic acid、1-(4-chlorobenzoyl)-5-methoxy-2-methyl-: ACTIVE、TRANSDERMAL INDOMETHACIN PHARMACEUTICALS CONTAIN POLYOXYETHYLENE ALKYL ETHERS AND、OR POLYOXYETHYLENE ALKYLPHENYL ESTERS (WHICH ARE LIQ AT 25 DEG) AND ACRYLIC ADHESIVES. |
登记用途：Uses: MEDICATION、Anti-Inflammatory Agents、Non-Steroidal、Cardiovascular Agents、Cyclooxygenase Inhibitors、Gout Suppressants、Tocolytic Agents、Use (kg) in Switzerland (2009): >100、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 4630、Consumption (g per capita) in Switzerland (2009): 0.013、Consumption (g per capita、approx.) in Germany (2009): 0.012、Consumption (g per capita) in the USA (2002): 0.016、Excretion rate: 0.275、Calculated removal (%): 78.5、For moderate to severe rheumatoid arthritis including acute flares of chronic disease、ankylosing spondylitis、osteoarthritis、acute painful shoulder (bursitis and、or tendinitis) and acute gouty arthritis.、Use Classification: Pharmaceuticals、Methods of Manufacturing: p-Anisidine + ethyl levulinate + p-chlorobenzoyl chloride (diazotisation、hydrogenation、Fischer indole synthesis、amide formation、saponification).、Acylation of sodium 2-(4-methoxy-phenyl)hydrazine-1-sulfonate with 4-chlorobenzoyl chloride followed by heating yields 1-(4- chlorobenzoyl)-1-(4-methoxyphenyl)hydrazine. Condensation with levulinic acid in a Fischer indole synthesis affords indomethacin.、Formulations、Preparations: Table: Indomethacin Preparations [Table#4437]、Table: Indomethacin Sodium Preparations [Table#4438]、General Manufacturing Information: 1H-Indole-3-acetic acid、1-(4-chlorobenzoyl)-5-methoxy-2-methyl-: ACTIVE、TRANSDERMAL INDOMETHACIN PHARMACEUTICALS CONTAIN POLYOXYETHYLENE ALKYL ETHERS AND、OR POLYOXYETHYLENE ALKYLPHENYL ESTERS (WHICH ARE LIQ AT 25 DEG) AND ACRYLIC ADHESIVES.。
消炎痛 是一种化工化合物，登记 CAS 号为 53-86-1，分子式 C19H16ClNO4（分子量 357.8）。
登记 CAS 号：53-86-1
其分子式 C19H16ClNO4 由 19 个碳、16 个氢、1 个氯、1 个氮、4 个氧 组成。
别名/同义词：消炎痛 · Indomethacin
消炎痛 的 CAS 登记号为 53-86-1。
分子式 C19H16ClNO4，分子量 357.8。
别名/同义词：消炎痛、Indomethacin。
登记用途：Uses: MEDICATION、Anti-Inflammatory Agents、Non-Steroidal、Cardiovascular Agents、Cyclooxygenase Inhibitors、Gout Suppressants、Tocolytic Agents、Use (kg) in Switzerland (2009): >100、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 4630、Consumption (g per capita) in Switzerland (2009): 0.013、Consumption (g per capita、approx.) in Germany (2009): 0.012、Consumption (g per capita) in the USA (2002): 0.016、Excretion rate: 0.275、Calculated removal (%): 78.5、For moderate to severe rheumatoid arthritis including acute flares of chronic disease、ankylosing spondylitis、osteoarthritis、acute painful shoulder (bursitis and、or tendinitis) and acute gouty arthritis.、Use Classification: Pharmaceuticals、Methods of Manufacturing: p-Anisidine + ethyl levulinate + p-chlorobenzoyl chloride (diazotisation、hydrogenation、Fischer indole synthesis、amide formation、saponification).、Acylation of sodium 2-(4-methoxy-phenyl)hydrazine-1-sulfonate with 4-chlorobenzoyl chloride followed by heating yields 1-(4- chlorobenzoyl)-1-(4-methoxyphenyl)hydrazine. Condensation with levulinic acid in a Fischer indole synthesis affords indomethacin.、Formulations、Preparations: Table: Indomethacin Preparations [Table#4437]、Table: Indomethacin Sodium Preparations [Table#4438]、General Manufacturing Information: 1H-Indole-3-acetic acid、1-(4-chlorobenzoyl)-5-methoxy-2-methyl-: ACTIVE、TRANSDERMAL INDOMETHACIN PHARMACEUTICALS CONTAIN POLYOXYETHYLENE ALKYL ETHERS AND、OR POLYOXYETHYLENE ALKYLPHENYL ESTERS (WHICH ARE LIQ AT 25 DEG) AND ACRYLIC ADHESIVES.。
消炎痛（CAS 53-86-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 53-86-1 |
|---|---|
| PubChem CID | 3715 |
| Molecular formula | C19H16ClNO4 |
| IUPAC name | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid |
| UNII (FDA) | XXE1CET956 |
| Molecular Weight | 357.8 |
|---|---|
| XLogP3 | 4.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 357.0767857 |
| Monoisotopic Mass | 357.0767857 |
| Topological Polar Surface Area | 68.5 |
| Heavy Atom Count | 25 |
| Melting Point | 311 or 323.6 °F (NTP, 1992) |
|---|---|
| Melting Point | 151 |
| Melting Point | MP: 160 °C |
| Melting Point | 158 °C |
| Solubility | 0.937 |
| Solubility | In water, 0.937 mg/L at 25 °C |
| Solubility | 2.40e-03 g/L |
| LogP | 4.27 |
| LogP | 3.4 |
| LogP | 3.86 |
indomethacin; 53-86-1; indometacin; Indomethacine; Indometacine; Indocid; Metindol; Reumacide; Indomethazine; Idomethine; Imbrilon; Mikametan; Indacin; Mobilan; Tannex; Amuno
| Reported hazard statements | H300 (81%), H301 (19%), H317 (24.9%), H318 (18.5%), H335 (18.5%), H336 (18.5%), H360 (25.4%), H373 (19%) |
|---|
H300 (81%): Fatal if swallowed [Danger Acute toxicity, oral]
H301 (19%): Toxic if swallowed [Danger Acute toxicity, oral]
Indomethacin · CAS 53-86-1 · C19H16ClNO4. UNII XXE1CET956. Melting Point: 311 or 323.6 °F (NTP, 1992); Melting Point: 151; Melting Point: MP: 160 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Indomethacin