布洛芬（CAS 58560-75-1）：分子式 C13H18O2、分子量 206.28。
| CAS号 | 58560-75-1 |
|---|---|
| 分子式 | C13H18O2 |
| 分子量 | 206.28 |
| 熔点 | 75-77.5 ºC |
| 沸点 | 157 |
| LogP | 3.97 |
| 应用领域 | Uses: THERAP CAT: Anti-inflammatory、analgesic、antipyretic、THERAP CAT (VET): Anti-inflammatory、Ingredient in over-the-counter pain relievers、Indicated for both acute and long-term management of rheumatoid arthritis、osteoarthritis、and psoriatic arthritis.、For more Uses (Complete) data for IBUPROFEN (7 total)、please visit the HSDB record page.、For symptomatic treatment of rheumatoid arthritis、juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis、gout and psoriatic arthritis. May reduce pain、fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.、Industry Uses: Intermediate、Consumer Uses: Intermediate、Methods of Manufacturing: Prepn: J.S. Nicholson、S.S. Adams、GB971700、eidem US 3385886 (1964、1968 both to Boots Pure Drug)、T. Shiori、N. Kawai、J. Org. Chem. 43、2936 (1978)、J.T. Pinhey、B.A. Rowe、Tetrahedron Letters 21、965 (1980).、Production: isobutylbenzene + acetyl chloride + triethylaluminum + potassium cyanide (Friedel-Crafts acylation、cyanohydrin formation、hydrogenation、nitrile hydrolysis)、Production: isobutylbenzene + propionyl chloride + methanol (Friedel-Crafts acylation、ketal formation、alpha bromination、rearrangement)、Production: isobutylbenzene + acetyl chloride + carbon monoxide (Friedel-Crafts acylation、carbonyl reduction、carbonylation)、For more Methods of Manufacturing (Complete) data for IBUPROFEN (6 total)、Formulations、Preparations: Generic. Tablets 200 (nonprescription)、300、400、600、and 800 mg. Advil (Whitehall)、Medipren (McNeil)、Midol 200 (Glenbrook)、Nuprin (Bristol-Myers). Tablets 200 mg (nonprescription). Children's Advil Suspension (Whitehall)、Pedia-Profen (McNeil). Suspension 100 mg、5 ml. Motrin (Upjohn). Tablets 200 (Motrin IB、nonprescription)、400 600、and 800 mg. Rufen (Boots). Tablets 400、and 800 mg.、Consumption Patterns: (1995) Estimated prescription amounts in Germany was 105 tons per year.、U.S. Production: 2023: 50、000 - <250、000 lb、2022: 50、2021: 50、2020: 50、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Benzeneacetic acid、.alpha.-methyl-4-(2-methylpropyl)-: ACTIVE、Ibuprofen ... is on the top ten list of pharmaceuticals used in Denmark in 1995 |
登记用途：Uses: THERAP CAT: Anti-inflammatory、analgesic、antipyretic、THERAP CAT (VET): Anti-inflammatory、Ingredient in over-the-counter pain relievers、Indicated for both acute and long-term management of rheumatoid arthritis、osteoarthritis、and psoriatic arthritis.、For more Uses (Complete) data for IBUPROFEN (7 total)、please visit the HSDB record page.、For symptomatic treatment of rheumatoid arthritis、juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis、gout and psoriatic arthritis. May reduce pain、fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.、Industry Uses: Intermediate、Consumer Uses: Intermediate、Methods of Manufacturing: Prepn: J.S. Nicholson、S.S. Adams、GB971700、eidem US 3385886 (1964、1968 both to Boots Pure Drug)、T. Shiori、N. Kawai、J. Org. Chem. 43、2936 (1978)、J.T. Pinhey、B.A. Rowe、Tetrahedron Letters 21、965 (1980).、Production: isobutylbenzene + acetyl chloride + triethylaluminum + potassium cyanide (Friedel-Crafts acylation、cyanohydrin formation、hydrogenation、nitrile hydrolysis)、Production: isobutylbenzene + propionyl chloride + methanol (Friedel-Crafts acylation、ketal formation、alpha bromination、rearrangement)、Production: isobutylbenzene + acetyl chloride + carbon monoxide (Friedel-Crafts acylation、carbonyl reduction、carbonylation)、For more Methods of Manufacturing (Complete) data for IBUPROFEN (6 total)、Formulations、Preparations: Generic. Tablets 200 (nonprescription)、300、400、600、and 800 mg. Advil (Whitehall)、Medipren (McNeil)、Midol 200 (Glenbrook)、Nuprin (Bristol-Myers). Tablets 200 mg (nonprescription). Children's Advil Suspension (Whitehall)、Pedia-Profen (McNeil). Suspension 100 mg、5 ml. Motrin (Upjohn). Tablets 200 (Motrin IB、nonprescription)、400 600、and 800 mg. Rufen (Boots). Tablets 400、and 800 mg.、Consumption Patterns: (1995) Estimated prescription amounts in Germany was 105 tons per year.、U.S. Production: 2023: 50、000 - <250、000 lb、2022: 50、2021: 50、2020: 50、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Benzeneacetic acid、.alpha.-methyl-4-(2-methylpropyl)-: ACTIVE、Ibuprofen ... is on the top ten list of pharmaceuticals used in Denmark in 1995。
布洛芬 是一种化工化合物，登记 CAS 号为 58560-75-1，分子式 C13H18O2（分子量 206.28）。
登记 CAS 号：58560-75-1
其分子式 C13H18O2 由 13 个碳、18 个氢、2 个氧 组成。
别名/同义词：布洛芬 · Ibuprofen
布洛芬 的 CAS 登记号为 58560-75-1。
分子式 C13H18O2，分子量 206.28。
别名/同义词：布洛芬、Ibuprofen。
登记用途：Uses: THERAP CAT: Anti-inflammatory、analgesic、antipyretic、THERAP CAT (VET): Anti-inflammatory、Ingredient in over-the-counter pain relievers、Indicated for both acute and long-term management of rheumatoid arthritis、osteoarthritis、and psoriatic arthritis.、For more Uses (Complete) data for IBUPROFEN (7 total)、please visit the HSDB record page.、For symptomatic treatment of rheumatoid arthritis、juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis、gout and psoriatic arthritis. May reduce pain、fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.、Industry Uses: Intermediate、Consumer Uses: Intermediate、Methods of Manufacturing: Prepn: J.S. Nicholson、S.S. Adams、GB971700、eidem US 3385886 (1964、1968 both to Boots Pure Drug)、T. Shiori、N. Kawai、J. Org. Chem. 43、2936 (1978)、J.T. Pinhey、B.A. Rowe、Tetrahedron Letters 21、965 (1980).、Production: isobutylbenzene + acetyl chloride + triethylaluminum + potassium cyanide (Friedel-Crafts acylation、cyanohydrin formation、hydrogenation、nitrile hydrolysis)、Production: isobutylbenzene + propionyl chloride + methanol (Friedel-Crafts acylation、ketal formation、alpha bromination、rearrangement)、Production: isobutylbenzene + acetyl chloride + carbon monoxide (Friedel-Crafts acylation、carbonyl reduction、carbonylation)、For more Methods of Manufacturing (Complete) data for IBUPROFEN (6 total)、Formulations、Preparations: Generic. Tablets 200 (nonprescription)、300、400、600、and 800 mg. Advil (Whitehall)、Medipren (McNeil)、Midol 200 (Glenbrook)、Nuprin (Bristol-Myers). Tablets 200 mg (nonprescription). Children's Advil Suspension (Whitehall)、Pedia-Profen (McNeil). Suspension 100 mg、5 ml. Motrin (Upjohn). Tablets 200 (Motrin IB、nonprescription)、400 600、and 800 mg. Rufen (Boots). Tablets 400、and 800 mg.、Consumption Patterns: (1995) Estimated prescription amounts in Germany was 105 tons per year.、U.S. Production: 2023: 50、000 - <250、000 lb、2022: 50、2021: 50、2020: 50、General Manufacturing Information: Pharmaceutical and Medicine Manufacturing、Benzeneacetic acid、.alpha.-methyl-4-(2-methylpropyl)-: ACTIVE、Ibuprofen ... is on the top ten list of pharmaceuticals used in Denmark in 1995。
布洛芬（CAS 58560-75-1）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 58560-75-1 |
|---|---|
| PubChem CID | 3672 |
| Molecular formula | C13H18O2 |
| IUPAC name | 2-[4-(2-methylpropyl)phenyl]propanoic acid |
| UNII (FDA) | WK2XYI10QM |
| Molecular Weight | 206.28 |
|---|---|
| XLogP3 | 3.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 4 |
| Exact Mass | 206.130679813 |
| Monoisotopic Mass | 206.130679813 |
| Topological Polar Surface Area | 37.3 |
| Heavy Atom Count | 15 |
| Boiling Point | 157 |
|---|---|
| Melting Point | 75-77.5 ºC |
| Melting Point | 75-77 °C |
| Melting Point | 76 °C |
| Solubility | 21 |
| Solubility | In water, 21 mg/l @ 25 °C |
| Solubility | 0.021 mg/mL at 25 °C |
| Vapor Pressure | 4.74X10-5 mm Hg @ 25 °C |
| LogP | 3.97 |
| LogP | log Kow= 3.97 |
58560-75-1; IBUPROFEN, (+-)-; RefChem:6648; ibuprofen; 15687-27-1; 2-(4-Isobutylphenyl)propanoic acid; Brufen; Motrin; Advil; 2-[4-(2-methylpropyl)phenyl]propanoic acid; Medipren; Nurofen; Liptan; Nuprin; Anflagen; Buburone
| Reported hazard statements | H302 (100%), H319 (72%), H335 (70.8%), H361 (17.8%), H360, H362, H371, H373 |
|---|
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H319 (72%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
Ibuprofen · CAS 58560-75-1 · C13H18O2. UNII WK2XYI10QM. Boiling Point: 157; Melting Point: 75-77.5 ºC; Melting Point: 75-77 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Ibuprofen