Grepafloxacin

Description

Grepafloxacin · CAS 119914-60-2 · C19H22FN3O3. UNII L1M1U2HC31. Solubility: 6.32e-01 g/L; LogP: 2.9.

Identification

CAS Registry Number	119914-60-2
PubChem CID	72474
Molecular formula	C19H22FN3O3
IUPAC name	1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
UNII (FDA)	L1M1U2HC31

Computed Descriptors

Molecular Weight	359.4
XLogP3	-0.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	359.16451973
Monoisotopic Mass	359.16451973
Topological Polar Surface Area	72.9
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Solubility	6.32e-01 g/L
LogP	2.9

Physical description & handling notes

• Solid
• Grepafloxacin has in vitro activity against a wide range of gram-positive and gram-negative aerobic microorganisms, as well as some atypical microorganisms.

GHS Hazard Classification

Reported hazard statements	H301 (100%)

Documented Uses

• For treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.
• Take with or without food. The absorption is unaffected by food.
• Substances that inhibit the growth or reproduction of BACTERIA.
• Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.
• J - Antiinfectives for systemic use
• J01 - Antibacterials for systemic use

Synonyms

Grepafloxacin; 119914-60-2; 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; Grepafloxacine; Grepafloxacino; 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; L1M1U2HC31; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-; OPC-17116; DTXSID2048321; grepafloxacinum; RefChem:922501; DTXCID0028296; J01MA11; (+--)-1-cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; (RS)-1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Grepafloxacin?

CAS 119914-60-2; molecular formula C19H22FN3O3; molecular weight — g/mol.

What other names is Grepafloxacin known by?

Grepafloxacin, 119914-60-2, 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid, Grepafloxacine, Grepafloxacino, 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

Is Grepafloxacin classified as hazardous?

Hazard statements reported: H301.

What are the key physical properties of Grepafloxacin?

Solubility: 6.32e-01 g/L; LogP: 2.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.