荧光素(CAS 2321-07-5):分子式 C20H12O5、分子量 332.3。
| CAS号 | 2321-07-5 |
|---|---|
| 分子式 | C20H12O5 |
| 分子量 | 332.3 |
| 熔点 | 315 |
| LogP | 3.4 |
| 应用领域 | Uses: Used as dye for cosmetics、cleansers、other household products、and vascular and ophthalmic diagnosis (may be in form of sodium salt)、Used as water indicator (detect leaks、pollution sources、and for sea rescues)、adsorption indicator、and dye intermediate、[HSDB] Used as analytical and clinical reagent、[Merck Index]、A presumptive reagent for dilute blood detection other than luminol is fluorescein.、Yellow dye for cosmetics、and other household products、tracing agent for water leaks、dye to detect water pollution sources、stic agent in ophthalmology (sodium salt)、chem int for dyes、As a marker for life saving at sea ...、and、detecting water leaks.、Dyeing seawater for spotting purposes、tracer to locate impurities in wells、dyeing silk and wool、indicator and reagent for bromine.、For more Uses (Complete) data for FLUORESCEIN (7 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 47.4、For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.、Methods of Manufacturing: Condensation of resorcinol with phthalic anhydride in the presence of zinc chloride、By heating phthalic anhydride and resorcinol.、Impurities: 2-(2-4、dihydroxybenzoyl)benzoic acid、Phthalic acid、Resorcinol、U.S. Production: (1986) No Data、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3868]、[US EPA、Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Spiro[isobenzofuran-1(3H)、9'-、U.S. Imports: (1983) 2.07X10+6、Acid Yellow 73、U.S. Exports: (1986) No Data、General Manufacturing Information: Spiro[isobenzofuran-1(3H)、9'-[9H]xanthen]-3-one、3'、6'-dihydroxy-: ACTIVE、Its diagnostic usefulness rests upon its fluorescence ... Appears readily in extracellular fluid and gains access only to viable cells ... Ulcerated areas ... stained green、foreign bodies ... surrounded by green ring、and loss of substance in conjunctiva ... indicated by yellow stain.、Color additives were initially regulated in the United States under the U.S. Department of Agriculture's (USDA) Bureau of Chemistry. In 1906、the Food and Drugs Act was passed by Congress、which prohibited the use of poisonous or deleterious colors in confectionery and the coloring or staining of food to conceal damage or inferiority. In 1927、responsibility of the Food and Drugs Act was transferred to FDA. Increasing government oversight、the Federal Food、Drug、and Cosmetic Act (FFDCA) was passed in 1938 and established the three following categories for colors: FD&C: colors used in foods、drugs and cosmetics、D&C: colors used in drugs and cosmetics when in contact with mucous membranes or ingested、and Ext. D&C: colors used in products applied externally. |
登记用途:Uses: Used as dye for cosmetics、cleansers、other household products、and vascular and ophthalmic diagnosis (may be in form of sodium salt)、Used as water indicator (detect leaks、pollution sources、and for sea rescues)、adsorption indicator、and dye intermediate、[HSDB] Used as analytical and clinical reagent、[Merck Index]、A presumptive reagent for dilute blood detection other than luminol is fluorescein.、Yellow dye for cosmetics、and other household products、tracing agent for water leaks、dye to detect water pollution sources、stic agent in ophthalmology (sodium salt)、chem int for dyes、As a marker for life saving at sea ...、and、detecting water leaks.、Dyeing seawater for spotting purposes、tracer to locate impurities in wells、dyeing silk and wool、indicator and reagent for bromine.、For more Uses (Complete) data for FLUORESCEIN (7 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 47.4、For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.、Methods of Manufacturing: Condensation of resorcinol with phthalic anhydride in the presence of zinc chloride、By heating phthalic anhydride and resorcinol.、Impurities: 2-(2-4、dihydroxybenzoyl)benzoic acid、Phthalic acid、Resorcinol、U.S. Production: (1986) No Data、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3868]、[US EPA、Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Spiro[isobenzofuran-1(3H)、9'-、U.S. Imports: (1983) 2.07X10+6、Acid Yellow 73、U.S. Exports: (1986) No Data、General Manufacturing Information: Spiro[isobenzofuran-1(3H)、9'-[9H]xanthen]-3-one、3'、6'-dihydroxy-: ACTIVE、Its diagnostic usefulness rests upon its fluorescence ... Appears readily in extracellular fluid and gains access only to viable cells ... Ulcerated areas ... stained green、foreign bodies ... surrounded by green ring、and loss of substance in conjunctiva ... indicated by yellow stain.、Color additives were initially regulated in the United States under the U.S. Department of Agriculture's (USDA) Bureau of Chemistry. In 1906、the Food and Drugs Act was passed by Congress、which prohibited the use of poisonous or deleterious colors in confectionery and the coloring or staining of food to conceal damage or inferiority. In 1927、responsibility of the Food and Drugs Act was transferred to FDA. Increasing government oversight、the Federal Food、Drug、and Cosmetic Act (FFDCA) was passed in 1938 and established the three following categories for colors: FD&C: colors used in foods、drugs and cosmetics、D&C: colors used in drugs and cosmetics when in contact with mucous membranes or ingested、and Ext. D&C: colors used in products applied externally.。
荧光素 是一种化工化合物,登记 CAS 号为 2321-07-5,分子式 C20H12O5(分子量 332.3)。
登记 CAS 号:2321-07-5
其分子式 C20H12O5 由 20 个碳、12 个氢、5 个氧 组成。
别名/同义词:荧光素 · Fluorescein
荧光素 的 CAS 登记号为 2321-07-5。
分子式 C20H12O5,分子量 332.3。
别名/同义词:荧光素、Fluorescein。
登记用途:Uses: Used as dye for cosmetics、cleansers、other household products、and vascular and ophthalmic diagnosis (may be in form of sodium salt)、Used as water indicator (detect leaks、pollution sources、and for sea rescues)、adsorption indicator、and dye intermediate、[HSDB] Used as analytical and clinical reagent、[Merck Index]、A presumptive reagent for dilute blood detection other than luminol is fluorescein.、Yellow dye for cosmetics、and other household products、tracing agent for water leaks、dye to detect water pollution sources、stic agent in ophthalmology (sodium salt)、chem int for dyes、As a marker for life saving at sea ...、and、detecting water leaks.、Dyeing seawater for spotting purposes、tracer to locate impurities in wells、dyeing silk and wool、indicator and reagent for bromine.、For more Uses (Complete) data for FLUORESCEIN (7 total)、please visit the HSDB record page.、Use (kg、approx.) in Germany (2009): >75、Consumption (g per capita、approx.) in Germany (2009): 0.000916、Calculated removal (%): 47.4、For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.、Methods of Manufacturing: Condensation of resorcinol with phthalic anhydride in the presence of zinc chloride、By heating phthalic anhydride and resorcinol.、Impurities: 2-(2-4、dihydroxybenzoyl)benzoic acid、Phthalic acid、Resorcinol、U.S. Production: (1986) No Data、Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#3868]、[US EPA、Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Spiro[isobenzofuran-1(3H)、9'-、U.S. Imports: (1983) 2.07X10+6、Acid Yellow 73、U.S. Exports: (1986) No Data、General Manufacturing Information: Spiro[isobenzofuran-1(3H)、9'-[9H]xanthen]-3-one、3'、6'-dihydroxy-: ACTIVE、Its diagnostic usefulness rests upon its fluorescence ... Appears readily in extracellular fluid and gains access only to viable cells ... Ulcerated areas ... stained green、foreign bodies ... surrounded by green ring、and loss of substance in conjunctiva ... indicated by yellow stain.、Color additives were initially regulated in the United States under the U.S. Department of Agriculture's (USDA) Bureau of Chemistry. In 1906、the Food and Drugs Act was passed by Congress、which prohibited the use of poisonous or deleterious colors in confectionery and the coloring or staining of food to conceal damage or inferiority. In 1927、responsibility of the Food and Drugs Act was transferred to FDA. Increasing government oversight、the Federal Food、Drug、and Cosmetic Act (FFDCA) was passed in 1938 and established the three following categories for colors: FD&C: colors used in foods、drugs and cosmetics、D&C: colors used in drugs and cosmetics when in contact with mucous membranes or ingested、and Ext. D&C: colors used in products applied externally.。
荧光素(CAS 2321-07-5)的独立参考数据,整理自公开化学数据库。
| CAS 号 | 2321-07-5 |
|---|---|
| PubChem CID | 16850 |
| 分子式 | C20H12O5 |
| IUPAC 名称 | 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one |
| UNII(FDA) | TPY09G7XIR |
| Molecular Weight | 332.3 |
|---|---|
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 0 |
| Exact Mass | 332.06847348 |
| Monoisotopic Mass | 332.06847348 |
| Topological Polar Surface Area | 76 |
| Heavy Atom Count | 25 |
| Melting Point | 315 |
|---|---|
| Melting Point | 315 °C (decomposes) |
| Melting Point | 315 °C |
| Solubility | 600 |
| Solubility | In water, 50 mg/L at 20 °C |
| Solubility | 2.55e-02 g/L |
| LogP | 3.4 |
| LogP | 4.3 |
| Color Additive Status | 74.1707 |
| Color Additive Status | 74.2707 |
荧光素; 2321-07-5;溶剂黄94;间苯二酚酞;黄色荧光素;荧光素;荧光素酸; 3,6-氟二醇; D&C 黄7号; 3',6'-二羟基荧烷;日本黄201; D和C黄7号; C.I.溶剂黄94;皂黄F;希达酸荧光素;黄7号
| 法规与食品接触 | FDA Regulatory Status of Color Additives: Drugs, Cosmetics |
|---|---|
| GHS 通报统计 | 3.4% (13 / 383) |
| GHS 通报统计 | 3.4% (13 / 383) |
|---|---|
| 已通报的危害声明 | H302 (13.6%), H319 (96.6%) |
荧光素 · CAS 2321-07-5 · C20H12O5. UNII TPY09G7XIR. Melting Point: 315; Melting Point: 315 °C (decomposes); Melting Point: 315 °C.
数据来源:PubChem / Wikidata;与随货 COA 不一致时以 COA 为准。
English page: Fluorescein