Finerenone

Description

Finerenone · CAS 1050477-31-0 · C21H22N4O3. UNII DE2O63YV8R. LogP: 2.51.

Identification

CAS Registry Number	1050477-31-0
PubChem CID	60150535
Molecular formula	C21H22N4O3
IUPAC name	(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
UNII (FDA)	DE2O63YV8R

Computed Descriptors

Molecular Weight	378.4
XLogP3	2.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	378.16919058
Monoisotopic Mass	378.16919058
Topological Polar Surface Area	110
Heavy Atom Count	28
Formal Charge	0

Physical & Chemical Properties

LogP	2.51

GHS Hazard Classification

Reported hazard statements	H301 (100%), H360 (66.7%), H362 (33.3%), H373 (33.3%), H410 (66.7%)

Documented Uses

• Finerenone is a selective, nonsteroidal mineralocorticoid receptor antagonist that is used in the therapy of chronic renal disease in patients with type 2 diabetes to slow progression of renal dysfunction and reduce the risk of cardiovascular disease morbidity and mortality. Finerenone has not been linked to serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
• Breast Feeding; Lactation; Mineralocorticoid Receptor Antagonists
• Avoid grapefruit products. Grapefruit products may increase exposure to finerenone, increasing the risk and severity of adverse effects.
• Take with or without food. Food does not have a clinically significant effect on area under the curve.
• Established Pharmacologic Class [EPC] - Nonsteroidal Mineralocorticoid-Receptor Antagonist
• Mechanisms of Action [MoA] - Mineralocorticoid Receptor Antagonists

Synonyms

Finerenone; 1050477-31-0; Kerendia; (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide; BAY94-8862; BAY 94-8862; finerenona; finerenonum; DE2O63YV8R; BAY-94-8862; (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide; DTXSID10146928; RefChem:57201; DTXCID5069419; 814-499-5; Finerenone (BAY 94-8862)

Frequently Asked Questions

What are the CAS number and molecular formula of Finerenone?

CAS 1050477-31-0; molecular formula C21H22N4O3; molecular weight — g/mol.

What other names is Finerenone known by?

Finerenone, 1050477-31-0, Kerendia, (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide, BAY94-8862, BAY 94-8862.

Is Finerenone classified as hazardous?

Hazard statements reported: H301, H360, H362, H373, H410.

What are the key physical properties of Finerenone?

LogP: 2.51.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.