雌二醇（CAS 50-28-2）：分子式 C18H24O2、分子量 272.4。
| CAS号 | 50-28-2 |
|---|---|
| 分子式 | C18H24O2 |
| 分子量 | 272.4 |
| 熔点 | 173 |
| 沸点 | 445.9±45.0 |
| LogP | 4.01 |
| 应用领域 | Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 515、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Consumption (g per capita) in the USA (2002): 0.00183、Calculated removal (%): 67、For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness、burning、pruritus and dyspareunia) and、or the lower urinary tract (urinary urgency and dysuria).、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> PRODUCTION_AID -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Cosmetics product ingredient: Estradiol 17beta (Estradiol)、Also known as: estradiol、oestradiol、E2、estrace、Source: Estradiol is a form of estrogen、a steroid hormone that is critical to the function of the reproductive system. Estradiol in cosmetics often comes from placental extract. Estradiol may also be isolated from urine of pregnant horses or synthesized from a plant-based compound. Placental extracts containing estradiol are added to some skin and hair treatments、including shampoos.、Potential health impacts: The major routes of exposure to estradiol in cosmetics are by absorption through the skin or by ingestion、depending on the specific product. Exposure to certain estrogens during fetal development is known to cause abnormalities of the urinary system or genital organs in both females and males. The U.S. Food and Drug Administration (U.S. FDA) categorizes estradiol as Pregnancy Category X、meaning that there is a risk to human fetuses from exposure to it. Studies of women exposed to estradiol have found an increase in risk of endometrial cancer. Use of estrogens after menopause is associated with an increased risk of breast cancer、as well as stroke、blood clots、and heart attacks. The National Toxicology Program (NTP) classifies estradiol and other steroidal estrogens as known human carcinogens.、Product count: 3、Methods of Manufacturing: Estradiol-17beta is produced commercially by the reduction of estrone using、for example、complex metal hydrides、such as sodium borohydride and lithium aluminum hydride.、Has been isolated from ovarian follicular fluid and from placental tissue ... It is usually prepared through reduction of the 17-keto group of Estrone.、Isolated from human and mare pregnancy urine.、Commercial synthesis from cholesterol or ergosterol.、Has also been isolated from urine of pregnant women and mares.、Impurities: Reported impurities (for estradiol hemihydrate) include: estra-1、3、5(10)、9(11)-tetraene-3、17beta-diol、estra-1、5(10)-triene-3、17alpha-diol (17alpha-estradiol)、3-hydroxyestra-1、5(10)-trien-17-one (estrone) and 4-methylestra-1、17beta-diol.、Estradiol hemihydrate、Formulations、Preparations: Estradiol is available commercially as oral and vaginal tablets、as a metered topical gel、as topical transdermal patches、as a vaginal cream and as an extended-release vaginal insert (ring).、Grade: NF (beta-form)、Commonly used preparations are the benzoate、dipropionate、and valerate、as well as ethinylestradiol.、General Manufacturing Information: Carcinogen |
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 515、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Consumption (g per capita) in the USA (2002): 0.00183、Calculated removal (%): 67、For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness、burning、pruritus and dyspareunia) and、or the lower urinary tract (urinary urgency and dysuria).、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> PRODUCTION_AID -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Cosmetics product ingredient: Estradiol 17beta (Estradiol)、Also known as: estradiol、oestradiol、E2、estrace、Source: Estradiol is a form of estrogen、a steroid hormone that is critical to the function of the reproductive system. Estradiol in cosmetics often comes from placental extract. Estradiol may also be isolated from urine of pregnant horses or synthesized from a plant-based compound. Placental extracts containing estradiol are added to some skin and hair treatments、including shampoos.、Potential health impacts: The major routes of exposure to estradiol in cosmetics are by absorption through the skin or by ingestion、depending on the specific product. Exposure to certain estrogens during fetal development is known to cause abnormalities of the urinary system or genital organs in both females and males. The U.S. Food and Drug Administration (U.S. FDA) categorizes estradiol as Pregnancy Category X、meaning that there is a risk to human fetuses from exposure to it. Studies of women exposed to estradiol have found an increase in risk of endometrial cancer. Use of estrogens after menopause is associated with an increased risk of breast cancer、as well as stroke、blood clots、and heart attacks. The National Toxicology Program (NTP) classifies estradiol and other steroidal estrogens as known human carcinogens.、Product count: 3、Methods of Manufacturing: Estradiol-17beta is produced commercially by the reduction of estrone using、for example、complex metal hydrides、such as sodium borohydride and lithium aluminum hydride.、Has been isolated from ovarian follicular fluid and from placental tissue ... It is usually prepared through reduction of the 17-keto group of Estrone.、Isolated from human and mare pregnancy urine.、Commercial synthesis from cholesterol or ergosterol.、Has also been isolated from urine of pregnant women and mares.、Impurities: Reported impurities (for estradiol hemihydrate) include: estra-1、3、5(10)、9(11)-tetraene-3、17beta-diol、estra-1、5(10)-triene-3、17alpha-diol (17alpha-estradiol)、3-hydroxyestra-1、5(10)-trien-17-one (estrone) and 4-methylestra-1、17beta-diol.、Estradiol hemihydrate、Formulations、Preparations: Estradiol is available commercially as oral and vaginal tablets、as a metered topical gel、as topical transdermal patches、as a vaginal cream and as an extended-release vaginal insert (ring).、Grade: NF (beta-form)、Commonly used preparations are the benzoate、dipropionate、and valerate、as well as ethinylestradiol.、General Manufacturing Information: Carcinogen。
雌二醇 是一种化工化合物，登记 CAS 号为 50-28-2，分子式 C18H24O2（分子量 272.4）。
登记 CAS 号：50-28-2
其分子式 C18H24O2 由 18 个碳、24 个氢、2 个氧 组成。
别名/同义词：雌二醇 · Estradiol
雌二醇 的 CAS 登记号为 50-28-2。
分子式 C18H24O2，分子量 272.4。
别名/同义词：雌二醇、Estradiol。
登记用途：Uses: MEDICATION、Use (kg、approx.) in Germany (2009): >250、Use (kg) in USA (2002): 515、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Consumption (g per capita) in the USA (2002): 0.00183、Calculated removal (%): 67、For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness、burning、pruritus and dyspareunia) and、or the lower urinary tract (urinary urgency and dysuria).、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Veterinary Drug -> PRODUCTION_AID -> JECFA Functional Classes、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Cosmetics product ingredient: Estradiol 17beta (Estradiol)、Also known as: estradiol、oestradiol、E2、estrace、Source: Estradiol is a form of estrogen、a steroid hormone that is critical to the function of the reproductive system. Estradiol in cosmetics often comes from placental extract. Estradiol may also be isolated from urine of pregnant horses or synthesized from a plant-based compound. Placental extracts containing estradiol are added to some skin and hair treatments、including shampoos.、Potential health impacts: The major routes of exposure to estradiol in cosmetics are by absorption through the skin or by ingestion、depending on the specific product. Exposure to certain estrogens during fetal development is known to cause abnormalities of the urinary system or genital organs in both females and males. The U.S. Food and Drug Administration (U.S. FDA) categorizes estradiol as Pregnancy Category X、meaning that there is a risk to human fetuses from exposure to it. Studies of women exposed to estradiol have found an increase in risk of endometrial cancer. Use of estrogens after menopause is associated with an increased risk of breast cancer、as well as stroke、blood clots、and heart attacks. The National Toxicology Program (NTP) classifies estradiol and other steroidal estrogens as known human carcinogens.、Product count: 3、Methods of Manufacturing: Estradiol-17beta is produced commercially by the reduction of estrone using、for example、complex metal hydrides、such as sodium borohydride and lithium aluminum hydride.、Has been isolated from ovarian follicular fluid and from placental tissue ... It is usually prepared through reduction of the 17-keto group of Estrone.、Isolated from human and mare pregnancy urine.、Commercial synthesis from cholesterol or ergosterol.、Has also been isolated from urine of pregnant women and mares.、Impurities: Reported impurities (for estradiol hemihydrate) include: estra-1、3、5(10)、9(11)-tetraene-3、17beta-diol、estra-1、5(10)-triene-3、17alpha-diol (17alpha-estradiol)、3-hydroxyestra-1、5(10)-trien-17-one (estrone) and 4-methylestra-1、17beta-diol.、Estradiol hemihydrate、Formulations、Preparations: Estradiol is available commercially as oral and vaginal tablets、as a metered topical gel、as topical transdermal patches、as a vaginal cream and as an extended-release vaginal insert (ring).、Grade: NF (beta-form)、Commonly used preparations are the benzoate、dipropionate、and valerate、as well as ethinylestradiol.、General Manufacturing Information: Carcinogen。
雌二醇（CAS 50-28-2）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 50-28-2 |
|---|---|
| PubChem CID | 5757 |
| Molecular formula | C18H24O2 |
| IUPAC name | (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
| UNII (FDA) | 4TI98Z838E |
| Molecular Weight | 272.4 |
|---|---|
| XLogP3 | 4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 272.177630004 |
| Monoisotopic Mass | 272.177630004 |
| Topological Polar Surface Area | 40.5 |
| Heavy Atom Count | 20 |
| Boiling Point | 445.9±45.0 |
|---|---|
| Melting Point | 173 |
| Melting Point | 178.5 °C |
| Melting Point | 178-179 °C |
| Solubility | 3.6 |
| Solubility | In water, 3.90 mg/L at 27 °C |
| Solubility | 0.0036 mg/mL |
| LogP | 4.01 |
| LogP | 3.15 |
| Dissociation Constants | 10.46±0.03 |
estradiol; beta-Estradiol; 50-28-2; 17beta-Estradiol; Oestradiol; Estrace; Dihydrofolliculin; Aquadiol; Diogynets; Divigel; Vivelle; Diogyn; Dihydrotheelin; Dihydroxyestrin; Dimenformon; Estraderm
| Regulatory & Food Contact | PRODUCTION_AID: Veterinary Drug 0-50 ng/kg bw TRS 893-JECFA 52/57 FAS 43-JECFA 52/43 |
|---|
| Reported hazard statements | H350 (39.6%), H351 (57.9%), H360 (82.4%), H362 (32.7%), H372 (34.6%), H400 (30.8%), H410 (36.5%) |
|---|
H350 (39.6%): May cause cancer [Danger Carcinogenicity]
H351 (57.9%): Suspected of causing cancer [Warning Carcinogenicity]
Estradiol · CAS 50-28-2 · C18H24O2. UNII 4TI98Z838E. Boiling Point: 445.9±45.0; Melting Point: 173; Melting Point: 178.5 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Estradiol