EPLERENONE

Description

EPLERENONE · CAS 107724-20-9 · C24H30O6. UNII 6995V82D0B. Solubility: 9.03e-03 g/L; LogP: 1.3.

Identification

CAS Registry Number	107724-20-9
PubChem CID	443872
Molecular formula	C24H30O6
IUPAC name	methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate
UNII (FDA)	6995V82D0B

Computed Descriptors

Molecular Weight	414.5
XLogP3	1.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	414.20423867
Monoisotopic Mass	414.20423867
Topological Polar Surface Area	82.2
Heavy Atom Count	30
Formal Charge	0

Physical & Chemical Properties

Solubility	9.03e-03 g/L
LogP	1.3

Physical description & handling notes

• Solid
• White to off-white crystalline powder
• Odorless
• Slightly soluble
• Very slightly soluble in water, with its solubility essentially pH dependent
• log Kow = 7.1 at pH 7.0

Regulatory Status

GHS notification summary	50% (2 / 4)

GHS Hazard Classification

GHS notification summary	50% (2 / 4)
Reported hazard statements	H302 (50%), H312 (25%), H317 (25%), H332 (25%), H361 (25%)

Documented Uses

• THERAP CAT: Antihypertensive. In treatment of congestive heart failure.
• Indicated to improve survival of stable patients with left ventricular systolic dysfunction ... and clinical evidence of congestive heart failure after acute myocardial infarction
• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Preparation: J. Grob, J. Kalvoda, EP 122232; eidem, US 4559332 (1984, 1985 both to Ciba-Geigy).
• For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.

Synonyms

Eplerenone; 107724-20-9; Inspra; SC-66110; (+)-Eplerenone; Eplerenona; DTXSID2046094; SC-6611O; 6995V82D0B; 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester; DTXCID0026094; CHEBI:31547; eplerenon; eplerenonum; RefChem:56430; C03DA04

Frequently Asked Questions

What are the CAS number and molecular formula of EPLERENONE?

CAS 107724-20-9; molecular formula C24H30O6; molecular weight — g/mol.

What other names is EPLERENONE known by?

Eplerenone, 107724-20-9, Inspra, SC-66110, (+)-Eplerenone, Eplerenona.

Is EPLERENONE classified as hazardous?

50% of GHS notifications report no hazard classification (2 of 4).

What are the key physical properties of EPLERENONE?

Solubility: 9.03e-03 g/L; LogP: 1.3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.