艾立康唑（CAS 164650-44-6）：分子式 C18H22F2N4O、分子量 348.4。
| CAS号 | 164650-44-6 |
|---|---|
| 分子式 | C18H22F2N4O |
| 分子量 | 348.4 |
| LogP | 2 |
| 应用领域 | Uses: Antifungal Agents、MEDICATION、Methods of Manufacturing: A new synthetic route、the shortest reported to date、to access a key intermediate for the synthesis of various triazole antifungal agents was developed. The elusive tetrasubstituted stereogenic center that is essential in advanced triazole antifungal agents was constructed via the catalytic asymmetric cyanosilylation of a ketone. The subsequent transformations were performed in two one-pot operations、enhancing the overall synthetic efficiency toward the intermediate. This streamlined synthetic approach was successfully applied to efficient enantioselective syntheses of efinaconazole (Jublia) ... .、Formulations、Preparations: For the topical treatment of onychomycosis、efinaconazole is commercially available as a 10% solution. The clear colorless to pale yellow solution contains efinaconazole in an alcohol-based vehicle. The topical solution also contains anhydrous citric acid、butylated hydroxytoluene、C12-15 alkyl lactate、cyclomethicone、diiospropyl adipate、disodium edetate、and purified water.、Topical: Solution、10%、(Jublia) Valeant. |
登记用途：Uses: Antifungal Agents、MEDICATION、Methods of Manufacturing: A new synthetic route、the shortest reported to date、to access a key intermediate for the synthesis of various triazole antifungal agents was developed. The elusive tetrasubstituted stereogenic center that is essential in advanced triazole antifungal agents was constructed via the catalytic asymmetric cyanosilylation of a ketone. The subsequent transformations were performed in two one-pot operations、enhancing the overall synthetic efficiency toward the intermediate. This streamlined synthetic approach was successfully applied to efficient enantioselective syntheses of efinaconazole (Jublia) ... .、Formulations、Preparations: For the topical treatment of onychomycosis、efinaconazole is commercially available as a 10% solution. The clear colorless to pale yellow solution contains efinaconazole in an alcohol-based vehicle. The topical solution also contains anhydrous citric acid、butylated hydroxytoluene、C12-15 alkyl lactate、cyclomethicone、diiospropyl adipate、disodium edetate、and purified water.、Topical: Solution、10%、(Jublia) Valeant.。
艾立康唑 是一种化工化合物，登记 CAS 号为 164650-44-6，分子式 C18H22F2N4O（分子量 348.4）。
登记 CAS 号：164650-44-6
其分子式 C18H22F2N4O 由 18 个碳、22 个氢、2 个氟、4 个氮、1 个氧 组成。
别名/同义词：艾立康唑 · Efinaconazole
艾立康唑 的 CAS 登记号为 164650-44-6。
分子式 C18H22F2N4O，分子量 348.4。
别名/同义词：艾立康唑、Efinaconazole。
登记用途：Uses: Antifungal Agents、MEDICATION、Methods of Manufacturing: A new synthetic route、the shortest reported to date、to access a key intermediate for the synthesis of various triazole antifungal agents was developed. The elusive tetrasubstituted stereogenic center that is essential in advanced triazole antifungal agents was constructed via the catalytic asymmetric cyanosilylation of a ketone. The subsequent transformations were performed in two one-pot operations、enhancing the overall synthetic efficiency toward the intermediate. This streamlined synthetic approach was successfully applied to efficient enantioselective syntheses of efinaconazole (Jublia) ... .、Formulations、Preparations: For the topical treatment of onychomycosis、efinaconazole is commercially available as a 10% solution. The clear colorless to pale yellow solution contains efinaconazole in an alcohol-based vehicle. The topical solution also contains anhydrous citric acid、butylated hydroxytoluene、C12-15 alkyl lactate、cyclomethicone、diiospropyl adipate、disodium edetate、and purified water.、Topical: Solution、10%、(Jublia) Valeant.。
艾立康唑（CAS 164650-44-6）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 164650-44-6 |
|---|---|
| PubChem CID | 489181 |
| Molecular formula | C18H22F2N4O |
| IUPAC name | (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol |
| UNII (FDA) | J82SB7FXWB |
| Molecular Weight | 348.4 |
|---|---|
| XLogP3 | 2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 348.17616766 |
| Monoisotopic Mass | 348.17616766 |
| Topological Polar Surface Area | 54.2 |
| Heavy Atom Count | 25 |
EFINACONAZOLE; 164650-44-6; (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; JUBLIA; KP-103; efinaconazol; Clenafin; KP103; Kp 103; efinaconazolum; IDP-108; J82SB7FXWB; CHEBI:82718; (2r,3r)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol; DTXSID40167787; (2R,3R)-2-(2,4-Difluorofenil)-3-(4-metilenopiperidin-1-il)-1-(1H-1,2,4-triazin-1-il)butan-2-ol
| Reported hazard statements | H361 (100%) |
|---|
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
Efinaconazole · CAS 164650-44-6 · C18H22F2N4O. UNII J82SB7FXWB.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Efinaconazole