Efinaconazole (CAS 164650-44-6) — formula C18H22F2N4O, molecular weight 348.4; category dyes and pigments.
Efinaconazole (CAS 164650-44-6) is a chemical raw material in the dyes and pigments category. Its molecular formula C18H22F2N4O comprises 18 C, 22 H, 2 F, 4 N, 1 O atoms. Its molecular weight is about 348.4. Reported physicochemical data: LogP about 2. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 164650-44-6 |
|---|---|
| Molecular Formula | C18H22F2N4O |
| Molecular Weight | 348.4 |
| LogP | 2 |
| Applications | Antifungal Agents, MEDICATION, Methods of Manufacturing: A new synthetic route, the shortest reported to date, to access a key intermediate for the synthesis of various triazole antifungal agents was developed. The elusive tetrasubstituted stereogenic center that is essential in advanced triazole antifungal agents was constructed via the catalytic asymmetric cyanosilylation of a ketone. The subsequent transformations were performed in two one-pot operations, enhancing the overall synthetic efficiency toward the intermediate. This streamlined synthetic approach was successfully applied to efficient enantioselective syntheses of efinaconazole (Jublia) |
| Category | Dyes & Pigments |
Documented applications: Antifungal Agents, MEDICATION, Methods of Manufacturing: A new synthetic route, the shortest reported to date, to access a key intermediate for the synthesis of various triazole antifungal agents was developed. The elusive tetrasubstituted stereogenic center that is essential in advanced triazole antifungal agents was constructed via the catalytic asymmetric cyanosilylation of a ketone. The subsequent transformations were performed in two one-pot operations, enhancing the overall synthetic efficiency toward the intermediate. This streamlined synthetic approach was successfully applied to efficient enantioselective syntheses of efinaconazole (Jublia).
Efinaconazole is a colorant or pigment compound with CAS registry number 164650-44-6 and molecular formula C18H22F2N4O (molecular weight 348.4), belonging to the dyes and pigments segment of chemical raw materials.
CAS number: 164650-44-6
Its molecular formula C18H22F2N4O comprises 18 C, 22 H, 2 F, 4 N, 1 O atoms.
Also known as: Efinaconazole · 艾立康唑
Category: dyes and pigments
The CAS registry number of Efinaconazole is 164650-44-6.
Molecular formula C18H22F2N4O, molecular weight 348.4.
It is also registered under: Efinaconazole, 艾立康唑.
Recorded applications: Antifungal Agents, MEDICATION, Methods of Manufacturing: A new synthetic route, the shortest reported to date, to access a key intermediate for the synthesis of various triazole antifungal agents was developed. The elusive tetrasubstituted stereogenic center that is essential in advanced triazole antifungal agents was constructed via the catalytic asymmetric cyanosilylation of a ketone. The subsequent transformations were performed in two one-pot operations, enhancing the overall synthetic efficiency toward the intermediate. This streamlined synthetic approach was successfully applied to efficient enantioselective syntheses of efinaconazole (Jublia).
Category: Dyes & Pigments.
Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.
Independent reference data for Efinaconazole (CAS 164650-44-6), compiled from public chemistry databases.
| CAS Registry Number | 164650-44-6 |
|---|---|
| PubChem CID | 489181 |
| Molecular formula | C18H22F2N4O |
| IUPAC name | (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol |
| UNII (FDA) | J82SB7FXWB |
| Molecular Weight | 348.4 |
|---|---|
| XLogP3 | 2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 348.17616766 |
| Monoisotopic Mass | 348.17616766 |
| Topological Polar Surface Area | 54.2 |
| Heavy Atom Count | 25 |
EFINACONAZOLE; 164650-44-6; (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; JUBLIA; KP-103; efinaconazol; Clenafin; KP103; Kp 103; efinaconazolum; IDP-108; J82SB7FXWB; CHEBI:82718; (2r,3r)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol; DTXSID40167787; (2R,3R)-2-(2,4-Difluorofenil)-3-(4-metilenopiperidin-1-il)-1-(1H-1,2,4-triazin-1-il)butan-2-ol
| Reported hazard statements | H361 (100%) |
|---|
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P280, P318, P405, and P501 (click each P-code to see the statement)
Efinaconazole · CAS 164650-44-6 · C18H22F2N4O. UNII J82SB7FXWB.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 艾立康唑