Dovitinib

CAS 405169-16-6C21H21FN6OMW 392.4

Dovitinib (CAS 405169-16-6) — formula C21H21FN6O, molecular weight 392.4.

Product Overview

CAS Number	405169-16-6
Molecular Formula	C21H21FN6O
Molecular Weight	392.4
LogP	1.6

Technical Profile

What this product is

Dovitinib is a chemical compound with CAS registry number 405169-16-6 and molecular formula C21H21FN6O (molecular weight 392.4).

Identification

CAS number: 405169-16-6

Its molecular formula C21H21FN6O comprises 21 C, 21 H, 1 F, 6 N, 1 O atoms.

Also known as: Dovitinib · 多韦替尼

Frequently Asked Questions

What is the CAS number of Dovitinib?

The CAS registry number of Dovitinib is 405169-16-6.

What is the molecular formula and molecular weight of Dovitinib?

Molecular formula C21H21FN6O, molecular weight 392.4.

What other names is Dovitinib known by?

It is also registered under: Dovitinib, 多韦替尼.

PubChem Public Data

Independent reference data for Dovitinib (CAS 405169-16-6), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	405169-16-6
PubChem CID	135398510
Molecular formula	C21H21FN6O
IUPAC name	4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one
UNII (FDA)	I35H55G906

Computed descriptors

Molecular Weight	392.4
XLogP3	1.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	392.17608748
Monoisotopic Mass	392.17608748
Topological Polar Surface Area	90.3
Heavy Atom Count	29

Documented uses on record

Investigated for use/treatment in multiple myeloma and solid tumors.
Unlike many kinase inhibitors that only target vascular endothelial growth factor (VEGF), Dovitinib inhibits receptors in the fibroblast growth factor (FGF ) pathway, as well as VEGF and platelet-derived growth factor (PDGF). FGF receptor tyrosine kinase inhibition is potentially of therapeutic significance to a group of myeloma patients whose cancer cells express high levels of surface FGF receptors.

Synonyms and trade names

Dovitinib; 405169-16-6; TKI-258; I35H55G906; GFKI-258; 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one; dovitinibum; 4-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl)-1,2-dihydroquinolin-2-one; RefChem:590385; 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one; Dovitinib [INN]; Chir 258; Dovitinib (TKI-258, CHIR-258); Dovitinib (TKI-258); Dovitinib lactate; 4-Amino-5-Fluoro-3-(6-(4-Methylpiperazin-1-yl)-1H-Benzo[D]Imidazol-2-yl)Quinolin-2(1H)-One

What the public record says

Dovitinib · CAS 405169-16-6 · C21H21FN6O. UNII I35H55G906.

Source: PubChem / Wikidata; the batch COA governs where values differ.