灰黄霉素（CAS 2884-22-2）：分子式 C17H17ClO6、分子量 352.8。
| CAS号 | 2884-22-2 |
|---|---|
| 分子式 | C17H17ClO6 |
| 分子量 | 352.8 |
| 熔点 | 428 °F (NTP, 1992) |
| LogP | 2.18 |
| 应用领域 | Uses: MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >250、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Calculated removal (%): 47.1、Griseofulvin is used both in animals and in humans、to treat fungal infections of the skin (commonly known as ringworm) and nails. Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. Griseofulvin is reserved for cases with nail、hair or large body surface involvement. (Wikipedia)、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: ANTIBIOTIC SUBSTANCE PRODUCED BY PENICULLIUM GRISEOFULVUM DIERCKX AND BY P. JANCZEWSKII ZAL. (= P. NIGRCANS (BANIER) THOM.). ISOLATION: OXFORD ET AL、BIOCHEM J 33、240 (1939)、BRIAN ET AL、TRANS BRIT MYCOL SOC 29、173 (1946)、HOCKENHULL、DOREY ET AL、US PATENT 3、069、328-9 (1962 TO GLAXO).、Formulations、Preparations: DUSTS 1.5-3.5% WT、WT FOR USE AT 75 LB、ACRE. WETTABLE POWDERS、DISPERSIBLE CONCENTRATES (SOLN IN DIMETHYL FORMAMIDE WITH DISPERSING AGENT).、SRP: NOT APPROVED FOR USE ON CROPS IN US.、GRISEOFULVIN、USP (FULVICIN U、F、GRIFULVIN V、GRISACTIN)、IS MARKETED IN CAPSULES CONTAINING 125 OR 250 MG & IN TABLETS CONTAINING 125、250、OR 500 MG、IT IS ALSO AVAIL AS ORAL SUSPENSION (125 MG、5 ML). ... TABLETS INCORPORATING ULTRAMICROSIZED PREPN (FULVICIN P、G、GRIS-PEG) CONTAIN 125 OR 250 MG OF GRISEOFULVIN (EQUIVALENT TO 250 OR 500 MG OF PREPN...ABOVE).、BIOAVAILABILITY OF A 500 MG MICROSIZE FORMULATION WAS COMPARED TO 2 NEW ULTRAMICROSIZE FORMULATIONS. ONE 330 MG ULTRAMICROSIZE TABLET IS BIOEQUIVALENT TO 2 165 MG ULTRAMICROSIZE TABLETS & EITHER ULTRAMICROSIZE DOSAGE REGIMEN IS BIOEQUIVALENT TO 500 MG OF THE MICROSIZE FORMULATION.、THE BIOAVAILABILITY OF GRISEOFULVIN TABLETS SPRAY DRIED WITH 20% METHYLCELLULOSE WAS DETERMINED IN 10 RABBITS. COMPARED TO REGULAR TABLETS、DRUG ABSORPTION WAS GREATER IN THE SPRAY DRIED PREPN.、Tablet、250 mg、500 mg、suspension、ml、Grifulvin V、U.S. Production: (1972) 2.5X10+7 GRAMS (SALES-HUMAN MEDICINE)、General Manufacturing Information: NOT APPROVED IN UNITED STATES IN FOOD PRODUCING ANIMALS. |
登记用途：Uses: MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >250、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Calculated removal (%): 47.1、Griseofulvin is used both in animals and in humans、to treat fungal infections of the skin (commonly known as ringworm) and nails. Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. Griseofulvin is reserved for cases with nail、hair or large body surface involvement. (Wikipedia)、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: ANTIBIOTIC SUBSTANCE PRODUCED BY PENICULLIUM GRISEOFULVUM DIERCKX AND BY P. JANCZEWSKII ZAL. (= P. NIGRCANS (BANIER) THOM.). ISOLATION: OXFORD ET AL、BIOCHEM J 33、240 (1939)、BRIAN ET AL、TRANS BRIT MYCOL SOC 29、173 (1946)、HOCKENHULL、DOREY ET AL、US PATENT 3、069、328-9 (1962 TO GLAXO).、Formulations、Preparations: DUSTS 1.5-3.5% WT、WT FOR USE AT 75 LB、ACRE. WETTABLE POWDERS、DISPERSIBLE CONCENTRATES (SOLN IN DIMETHYL FORMAMIDE WITH DISPERSING AGENT).、SRP: NOT APPROVED FOR USE ON CROPS IN US.、GRISEOFULVIN、USP (FULVICIN U、F、GRIFULVIN V、GRISACTIN)、IS MARKETED IN CAPSULES CONTAINING 125 OR 250 MG & IN TABLETS CONTAINING 125、250、OR 500 MG、IT IS ALSO AVAIL AS ORAL SUSPENSION (125 MG、5 ML). ... TABLETS INCORPORATING ULTRAMICROSIZED PREPN (FULVICIN P、G、GRIS-PEG) CONTAIN 125 OR 250 MG OF GRISEOFULVIN (EQUIVALENT TO 250 OR 500 MG OF PREPN...ABOVE).、BIOAVAILABILITY OF A 500 MG MICROSIZE FORMULATION WAS COMPARED TO 2 NEW ULTRAMICROSIZE FORMULATIONS. ONE 330 MG ULTRAMICROSIZE TABLET IS BIOEQUIVALENT TO 2 165 MG ULTRAMICROSIZE TABLETS & EITHER ULTRAMICROSIZE DOSAGE REGIMEN IS BIOEQUIVALENT TO 500 MG OF THE MICROSIZE FORMULATION.、THE BIOAVAILABILITY OF GRISEOFULVIN TABLETS SPRAY DRIED WITH 20% METHYLCELLULOSE WAS DETERMINED IN 10 RABBITS. COMPARED TO REGULAR TABLETS、DRUG ABSORPTION WAS GREATER IN THE SPRAY DRIED PREPN.、Tablet、250 mg、500 mg、suspension、ml、Grifulvin V、U.S. Production: (1972) 2.5X10+7 GRAMS (SALES-HUMAN MEDICINE)、General Manufacturing Information: NOT APPROVED IN UNITED STATES IN FOOD PRODUCING ANIMALS.。
灰黄霉素 是一种化工化合物，登记 CAS 号为 2884-22-2，分子式 C17H17ClO6（分子量 352.8）。
登记 CAS 号：2884-22-2
其分子式 C17H17ClO6 由 17 个碳、17 个氢、1 个氯、6 个氧 组成。
别名/同义词：灰黄霉素 · dl-Griseofulvin
灰黄霉素 的 CAS 登记号为 2884-22-2。
分子式 C17H17ClO6，分子量 352.8。
别名/同义词：灰黄霉素、dl-Griseofulvin。
登记用途：Uses: MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >250、Consumption (g per capita、approx.) in Germany (2009): 0.00305、Calculated removal (%): 47.1、Griseofulvin is used both in animals and in humans、to treat fungal infections of the skin (commonly known as ringworm) and nails. Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. Griseofulvin is reserved for cases with nail、hair or large body surface involvement. (Wikipedia)、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Methods of Manufacturing: ANTIBIOTIC SUBSTANCE PRODUCED BY PENICULLIUM GRISEOFULVUM DIERCKX AND BY P. JANCZEWSKII ZAL. (= P. NIGRCANS (BANIER) THOM.). ISOLATION: OXFORD ET AL、BIOCHEM J 33、240 (1939)、BRIAN ET AL、TRANS BRIT MYCOL SOC 29、173 (1946)、HOCKENHULL、DOREY ET AL、US PATENT 3、069、328-9 (1962 TO GLAXO).、Formulations、Preparations: DUSTS 1.5-3.5% WT、WT FOR USE AT 75 LB、ACRE. WETTABLE POWDERS、DISPERSIBLE CONCENTRATES (SOLN IN DIMETHYL FORMAMIDE WITH DISPERSING AGENT).、SRP: NOT APPROVED FOR USE ON CROPS IN US.、GRISEOFULVIN、USP (FULVICIN U、F、GRIFULVIN V、GRISACTIN)、IS MARKETED IN CAPSULES CONTAINING 125 OR 250 MG & IN TABLETS CONTAINING 125、250、OR 500 MG、IT IS ALSO AVAIL AS ORAL SUSPENSION (125 MG、5 ML). ... TABLETS INCORPORATING ULTRAMICROSIZED PREPN (FULVICIN P、G、GRIS-PEG) CONTAIN 125 OR 250 MG OF GRISEOFULVIN (EQUIVALENT TO 250 OR 500 MG OF PREPN...ABOVE).、BIOAVAILABILITY OF A 500 MG MICROSIZE FORMULATION WAS COMPARED TO 2 NEW ULTRAMICROSIZE FORMULATIONS. ONE 330 MG ULTRAMICROSIZE TABLET IS BIOEQUIVALENT TO 2 165 MG ULTRAMICROSIZE TABLETS & EITHER ULTRAMICROSIZE DOSAGE REGIMEN IS BIOEQUIVALENT TO 500 MG OF THE MICROSIZE FORMULATION.、THE BIOAVAILABILITY OF GRISEOFULVIN TABLETS SPRAY DRIED WITH 20% METHYLCELLULOSE WAS DETERMINED IN 10 RABBITS. COMPARED TO REGULAR TABLETS、DRUG ABSORPTION WAS GREATER IN THE SPRAY DRIED PREPN.、Tablet、250 mg、500 mg、suspension、ml、Grifulvin V、U.S. Production: (1972) 2.5X10+7 GRAMS (SALES-HUMAN MEDICINE)、General Manufacturing Information: NOT APPROVED IN UNITED STATES IN FOOD PRODUCING ANIMALS.。
灰黄霉素（CAS 2884-22-2）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 2884-22-2 |
|---|---|
| PubChem CID | 441140 |
| 分子式 | C17H17ClO6 |
| IUPAC 名称 | (2S,5'R)-7-chloro-3',4,6-trimethoxy-5'-methylspiro[1-benzofuran-2,4'-cyclohex-2-ene]-1',3-dione |
| UNII（FDA） | 32HRV3E3D5 |
| Molecular Weight | 352.8 |
|---|---|
| XLogP3 | 2.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 352.0713660 |
| Monoisotopic Mass | 352.0713660 |
| Topological Polar Surface Area | 71.1 |
| Heavy Atom Count | 24 |
| Melting Point | 428 °F (NTP, 1992) |
|---|---|
| Melting Point | 220 |
| Melting Point | 220 °C |
| Solubility | 8.64 |
| Solubility | 5.04e-02 g/L |
| LogP | 2.18 |
| LogP | LogP = 2.18 |
griseofulvin; 126-07-8; (+)-Griseofulvin; Fulvicin; Amudane; Fulcin; Griseofulvina; Griseofulvinum; Grifulvin; Grisactin; Grisovin; Spirofulvin; Lamoryl; Curling factor; Grisefuline; Griseofulvine
| GHS 通报统计 | 0.7% (1 / 149) |
|---|
| GHS 通报统计 | 0.7% (1 / 149) |
|---|---|
| 已通报的危害声明 | H317 (90.6%), H351 (98%), H360 (98%), H340, H371, H373 |
灰黄霉素 · CAS 2884-22-2 · C17H17ClO6. UNII 32HRV3E3D5. Melting Point: 428 °F (NTP, 1992); Melting Point: 220; Melting Point: 220 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: dl-Griseofulvin