Diphenhydramine hydrochloride

CAS 147-24-0C17H21NOMW 255.35

Diphenhydramine hydrochloride (CAS 147-24-0) — formula C17H21NO, molecular weight 255.35.

Product Overview

CAS Number	147-24-0
Molecular Formula	C17H21NO
Molecular Weight	255.35
Melting Point	161-162
Boiling Point	150-165 °C at 2.00E+00 mm Hg
LogP	3.27
Applications	Uses: Anesthetics, Local, Anti-Allergic Agents, Antiemetics, Histamine H1 Antagonists, Hypnotics and Sedatives, MEDICATION, MEDICATION (VET), Use (kg, approx.) in Germany (2009): >2500, Use (kg) in USA (2002): 13500, Consumption (g per capita, approx.) in Germany (2009): 0.0305, Consumption (g per capita) in the USA (2002): 0.0479, Excretion rate: 0.018, Calculated removal (%): 36.4, For the treatment of symptoms associated with Vertigo, Meniere's disease, nausea and vomiting, motion sickness and insect bite., Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: By heating diphenylbromomethane, beta-dimethylamino-ethanol, and sodium carbonate in toluene. After distilling off the toluene, the purified diphenhydramine is converted to the hydrochloride with hydrogen chloride., Diphenhydramine hydrochloride, Formulations, Preparations: Table: Diphenhydramine Hydrochloride Preparations [Table#4378], Benadryl, Benocten, Nytol, Sedopretten, Sominex, Unisom Sleepgels., U.S. Production: (1976) PROBABLY GREATER THAN 9.08X10+5 GRAMS, (1978) PROBABLY GREATER THAN 9.08X10+5 GRAMS, U.S. Imports: (1976) 4.10X10+6 GRAMS (PRINCPL CUSTMS DISTS), (1978) 4.40X10+6 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: Ethanamine, 2-(diphenylmethoxy)-N, N-dimethyl-: INACTIVE

Applications

Documented applications: Uses: Anesthetics, Local, Anti-Allergic Agents, Antiemetics, Histamine H1 Antagonists, Hypnotics and Sedatives, MEDICATION, MEDICATION (VET), Use (kg, approx.) in Germany (2009): >2500, Use (kg) in USA (2002): 13500, Consumption (g per capita, approx.) in Germany (2009): 0.0305, Consumption (g per capita) in the USA (2002): 0.0479, Excretion rate: 0.018, Calculated removal (%): 36.4, For the treatment of symptoms associated with Vertigo, Meniere's disease, nausea and vomiting, motion sickness and insect bite., Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: By heating diphenylbromomethane, beta-dimethylamino-ethanol, and sodium carbonate in toluene. After distilling off the toluene, the purified diphenhydramine is converted to the hydrochloride with hydrogen chloride., Diphenhydramine hydrochloride, Formulations, Preparations: Table: Diphenhydramine Hydrochloride Preparations [Table#4378], Benadryl, Benocten, Nytol, Sedopretten, Sominex, Unisom Sleepgels., U.S. Production: (1976) PROBABLY GREATER THAN 9.08X10+5 GRAMS, (1978) PROBABLY GREATER THAN 9.08X10+5 GRAMS, U.S. Imports: (1976) 4.10X10+6 GRAMS (PRINCPL CUSTMS DISTS), (1978) 4.40X10+6 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: Ethanamine, 2-(diphenylmethoxy)-N, N-dimethyl-: INACTIVE.

Technical Profile

What this product is

Diphenhydramine hydrochloride is a chemical compound with CAS registry number 147-24-0 and molecular formula C17H21NO (molecular weight 255.35).

Identification

CAS number: 147-24-0

Its molecular formula C17H21NO comprises 17 C, 21 H, 1 N, 1 O atoms.

Also known as: Diphenhydramine hydrochloride · 盐酸苯海拉明

Frequently Asked Questions

What is the CAS number of Diphenhydramine hydrochloride?

The CAS registry number of Diphenhydramine hydrochloride is 147-24-0.

What is the molecular formula and molecular weight of Diphenhydramine hydrochloride?

Molecular formula C17H21NO, molecular weight 255.35.

What other names is Diphenhydramine hydrochloride known by?

It is also registered under: Diphenhydramine hydrochloride, 盐酸苯海拉明.

What are the documented applications of Diphenhydramine hydrochloride?

Recorded applications: Uses: Anesthetics, Local, Anti-Allergic Agents, Antiemetics, Histamine H1 Antagonists, Hypnotics and Sedatives, MEDICATION, MEDICATION (VET), Use (kg, approx.) in Germany (2009): >2500, Use (kg) in USA (2002): 13500, Consumption (g per capita, approx.) in Germany (2009): 0.0305, Consumption (g per capita) in the USA (2002): 0.0479, Excretion rate: 0.018, Calculated removal (%): 36.4, For the treatment of symptoms associated with Vertigo, Meniere's disease, nausea and vomiting, motion sickness and insect bite., Use Classification: Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Methods of Manufacturing: By heating diphenylbromomethane, beta-dimethylamino-ethanol, and sodium carbonate in toluene. After distilling off the toluene, the purified diphenhydramine is converted to the hydrochloride with hydrogen chloride., Diphenhydramine hydrochloride, Formulations, Preparations: Table: Diphenhydramine Hydrochloride Preparations [Table#4378], Benadryl, Benocten, Nytol, Sedopretten, Sominex, Unisom Sleepgels., U.S. Production: (1976) PROBABLY GREATER THAN 9.08X10+5 GRAMS, (1978) PROBABLY GREATER THAN 9.08X10+5 GRAMS, U.S. Imports: (1976) 4.10X10+6 GRAMS (PRINCPL CUSTMS DISTS), (1978) 4.40X10+6 GRAMS (PRINCPL CUSTMS DISTS), General Manufacturing Information: Ethanamine, 2-(diphenylmethoxy)-N, N-dimethyl-: INACTIVE.

PubChem Public Data

Independent reference data for Diphenhydramine hydrochloride (CAS 147-24-0), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	147-24-0
PubChem CID	3100
Molecular formula	C17H21NO
IUPAC name	2-benzhydryloxy-N,N-dimethylethanamine
UNII (FDA)	8GTS82S83M

Computed descriptors

Molecular Weight	255.35
XLogP3	3.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	255.162314293
Monoisotopic Mass	255.162314293
Topological Polar Surface Area	12.5
Heavy Atom Count	19

Physicochemical values on record

Boiling Point	150-165 °C at 2.00E+00 mm Hg
Boiling Point	BP: 165 °C at 3 mm Hg
Boiling Point	BP: 150-165 °C at 2.0 mm Hg
Melting Point	161-162
Melting Point	168 °C
Solubility	3060
Solubility	In water, 3.06X10+3 mg/L at 37 °C
LogP	3.27
LogP	log Kow = 3.27
LogP	3.4

Documented uses on record

Synonyms and trade names

diphenhydramine; 58-73-1; Benzhydramine; Alledryl; Probedryl; Dihidral; Antistominum; Benzhydraminum; Benzhydroamina; Diphantine; Baramine; Dermodrin; Desentol; Dibondrin; Histaxin; Benylan

GHS hazard classification

Reported hazard statements	H302 (100%), H315 (66.7%), H319 (66.7%)

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]

What the public record says

(2-Diphenylmethoxyethyl)Dimethylamine Hydrochloride · CAS 147-24-0 · C17H21NO. UNII 8GTS82S83M. Boiling Point: 150-165 °C at 2.00E+00 mm Hg; Boiling Point: BP: 165 °C at 3 mm Hg; Boiling Point: BP: 150-165 °C at 2.0 mm Hg.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.