地尔硫卓（CAS 42399-41-7）：分子式 C22H26N2O4S、分子量 414.5。
| CAS号 | 42399-41-7 |
|---|---|
| 分子式 | C22H26N2O4S |
| 分子量 | 414.5 |
| 熔点 | 187-188 |
| LogP | 2.8 |
| 应用领域 | Uses: Medication、Medication (Vet)、Use (kg、approx.) in Germany (2009): >5000、Use (kg) in USA (2002): 97800、Consumption (g per capita、approx.) in Germany (2009): 0.0611、Consumption (g per capita) in the USA (2002): 0.347、Excretion rate: 0.1、Calculated removal (%): 11.8、For the treatment of hypertension.、Use Classification: Pharmaceuticals、Methods of Manufacturing: p-Anisaldehyde + methyl chloroacetate + 2-aminothiophenol + acetic anhydride + 2-dimethylaminoethyl chloride hydrochloride (Darzens reaction、epoxidation、saponification、racemate separation、condensation、amine formation)、Prepn (unspec stereochem): H. Kugita et al.、DE 1805714、eidem、US 3562257 (1969、1971 both to Tanabe Seiyaku)、Chem. Pharm. Bull. 19、595 (1971). ...Stereospecific synthesis: K. Igarashi、T. Honma、DE 3415035、US 4552695 (1984、1985 both to Shionogi)、Formulations、Preparations: Available commercially as the (+)-cis-isomer hydrochloride salt.、Cardizem、Diltiazem hydrochloride、Dilacor-XR、Tiazac、For more Formulations、Preparations (Complete) data for DILTIAZEM (6 total)、please visit the HSDB record page. |
登记用途：Uses: Medication、Medication (Vet)、Use (kg、approx.) in Germany (2009): >5000、Use (kg) in USA (2002): 97800、Consumption (g per capita、approx.) in Germany (2009): 0.0611、Consumption (g per capita) in the USA (2002): 0.347、Excretion rate: 0.1、Calculated removal (%): 11.8、For the treatment of hypertension.、Use Classification: Pharmaceuticals、Methods of Manufacturing: p-Anisaldehyde + methyl chloroacetate + 2-aminothiophenol + acetic anhydride + 2-dimethylaminoethyl chloride hydrochloride (Darzens reaction、epoxidation、saponification、racemate separation、condensation、amine formation)、Prepn (unspec stereochem): H. Kugita et al.、DE 1805714、eidem、US 3562257 (1969、1971 both to Tanabe Seiyaku)、Chem. Pharm. Bull. 19、595 (1971). ...Stereospecific synthesis: K. Igarashi、T. Honma、DE 3415035、US 4552695 (1984、1985 both to Shionogi)、Formulations、Preparations: Available commercially as the (+)-cis-isomer hydrochloride salt.、Cardizem、Diltiazem hydrochloride、Dilacor-XR、Tiazac、For more Formulations、Preparations (Complete) data for DILTIAZEM (6 total)、please visit the HSDB record page.。
地尔硫卓 是一种化工化合物，登记 CAS 号为 42399-41-7，分子式 C22H26N2O4S（分子量 414.5）。
登记 CAS 号：42399-41-7
其分子式 C22H26N2O4S 由 22 个碳、26 个氢、2 个氮、4 个氧、1 个硫 组成。
别名/同义词：地尔硫卓 · Diltiazem
地尔硫卓 的 CAS 登记号为 42399-41-7。
分子式 C22H26N2O4S，分子量 414.5。
别名/同义词：地尔硫卓、Diltiazem。
登记用途：Uses: Medication、Medication (Vet)、Use (kg、approx.) in Germany (2009): >5000、Use (kg) in USA (2002): 97800、Consumption (g per capita、approx.) in Germany (2009): 0.0611、Consumption (g per capita) in the USA (2002): 0.347、Excretion rate: 0.1、Calculated removal (%): 11.8、For the treatment of hypertension.、Use Classification: Pharmaceuticals、Methods of Manufacturing: p-Anisaldehyde + methyl chloroacetate + 2-aminothiophenol + acetic anhydride + 2-dimethylaminoethyl chloride hydrochloride (Darzens reaction、epoxidation、saponification、racemate separation、condensation、amine formation)、Prepn (unspec stereochem): H. Kugita et al.、DE 1805714、eidem、US 3562257 (1969、1971 both to Tanabe Seiyaku)、Chem. Pharm. Bull. 19、595 (1971). ...Stereospecific synthesis: K. Igarashi、T. Honma、DE 3415035、US 4552695 (1984、1985 both to Shionogi)、Formulations、Preparations: Available commercially as the (+)-cis-isomer hydrochloride salt.、Cardizem、Diltiazem hydrochloride、Dilacor-XR、Tiazac、For more Formulations、Preparations (Complete) data for DILTIAZEM (6 total)、please visit the HSDB record page.。
地尔硫卓（CAS 42399-41-7）的独立参考数据，整理自公开化学数据库。
| CAS 号 | 42399-41-7 |
|---|---|
| PubChem CID | 39186 |
| 分子式 | C22H26N2O4S |
| IUPAC 名称 | [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate |
| UNII（FDA） | EE92BBP03H |
| Molecular Weight | 414.5 |
|---|---|
| XLogP3 | 3.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 7 |
| Exact Mass | 414.16132849 |
| Monoisotopic Mass | 414.16132849 |
| Topological Polar Surface Area | 84.4 |
| Heavy Atom Count | 29 |
| Melting Point | 187-188 |
|---|---|
| Melting Point | 212 °C (decomposes) |
| Melting Point | 231 °C |
| Solubility | 465 |
| Solubility | In water, 465 mg/l @ 25 °C |
| Solubility | 1.68e-02 g/L |
| LogP | 2.8 |
| LogP | log Kow = 2.70 |
| LogP | 2.93 |
| Dissociation Constants | 8.02 |
diltiazem; 42399-41-7; d-cis-Diltiazem; Dilcontin; Dilticard; Acalix; Anoheal; Incoril AP; Diltiazemum; Surazem; Dilacor-XR; Herbesser; Ditiaz; Diltiazem extended release; EE92BBP03H; Diltia XT
地尔硫卓 · CAS 42399-41-7 · C22H26N2O4S. UNII EE92BBP03H. Melting Point: 187-188; Melting Point: 212 °C (decomposes); Melting Point: 231 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Diltiazem