Diclofenac resinate（CAS 15307-86-5）：分子式 C14H11Cl2NO2、分子量 296.1。
| CAS号 | 15307-86-5 |
|---|---|
| 分子式 | C14H11Cl2NO2 |
| 分子量 | 296.1 |
| 熔点 | 283-285 °C |
| LogP | 4.51 |
| 应用领域 | Uses: MEDICATION、Use (kg) in Switzerland (2009): >5000、Use (kg、approx.) in Germany (2009): >75000、exact) in Germany (2009): 91583、Use (kg) in USA (2002): 9480、Use (kg) in France (2004): 9896、Consumption (g per capita) in Switzerland (2009): 0.64、Consumption (g per capita、approx.) in Germany (2009): 0.92、exact) in Germany (2009): 1.1、Consumption (g per capita) in the USA (2002): 0.034、Consumption (g per capita) in France (2004): 0.16、Excretion rate: 0.16、Calculated removal (%): 86.6、For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.、Use Classification: Pharmaceuticals -> Musculo-skeletal system -> Antiinflammatory and antirheumatic products -> Antiinflammatory and antirheumatic products、non-steroids -> Acetic acid derivatives and related substances、Pharmaceuticals、Methods of Manufacturing: Oxalyl chloride and 2、6-dichlorodiphenylamine are condensed to form the N、N-diphenyloxanilyl chloride that cyclizes under Friedel-Crafts conditions to yield 1-(2、6-diphenyl)isatin. Wolff-Kishner reduction of the 3-oxo group gives the lactam、which on hydrolysis affords the free acid. Neutralization with NaOH produces the salt.、Diclofenac sodium、Preparation: NL 6604752、A. Sallmann、R. Pfister、US 3558690 (1966、1971 both to Geigy)、Formulations、Preparations: Table: Diclofenac Sodium Combination Preparations [Table#6838]、Table: Diclofenac Potassium Preparations [Table#6839]、Table: Diclofenac Epolamine Preparations [Table#6840]、Table: Diclofenac Sodium Preparations [Table#6841]、Table: Diclofenac Preparations [Table#6842]、General Manufacturing Information: Synthesis: acylation of N-phenyl-2、6-dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide、which is fused with aluminum chloride to give 1-(2、6-dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.、Diclofenac Sodium、A Sallmann、R Pfister |
登记用途：Uses: MEDICATION、Use (kg) in Switzerland (2009): >5000、Use (kg、approx.) in Germany (2009): >75000、exact) in Germany (2009): 91583、Use (kg) in USA (2002): 9480、Use (kg) in France (2004): 9896、Consumption (g per capita) in Switzerland (2009): 0.64、Consumption (g per capita、approx.) in Germany (2009): 0.92、exact) in Germany (2009): 1.1、Consumption (g per capita) in the USA (2002): 0.034、Consumption (g per capita) in France (2004): 0.16、Excretion rate: 0.16、Calculated removal (%): 86.6、For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.、Use Classification: Pharmaceuticals -> Musculo-skeletal system -> Antiinflammatory and antirheumatic products -> Antiinflammatory and antirheumatic products、non-steroids -> Acetic acid derivatives and related substances、Pharmaceuticals、Methods of Manufacturing: Oxalyl chloride and 2、6-dichlorodiphenylamine are condensed to form the N、N-diphenyloxanilyl chloride that cyclizes under Friedel-Crafts conditions to yield 1-(2、6-diphenyl)isatin. Wolff-Kishner reduction of the 3-oxo group gives the lactam、which on hydrolysis affords the free acid. Neutralization with NaOH produces the salt.、Diclofenac sodium、Preparation: NL 6604752、A. Sallmann、R. Pfister、US 3558690 (1966、1971 both to Geigy)、Formulations、Preparations: Table: Diclofenac Sodium Combination Preparations [Table#6838]、Table: Diclofenac Potassium Preparations [Table#6839]、Table: Diclofenac Epolamine Preparations [Table#6840]、Table: Diclofenac Sodium Preparations [Table#6841]、Table: Diclofenac Preparations [Table#6842]、General Manufacturing Information: Synthesis: acylation of N-phenyl-2、6-dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide、which is fused with aluminum chloride to give 1-(2、6-dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.、Diclofenac Sodium、A Sallmann、R Pfister。
Diclofenac resinate 是一种化工化合物，登记 CAS 号为 15307-86-5，分子式 C14H11Cl2NO2（分子量 296.1）。
登记 CAS 号：15307-86-5
其分子式 C14H11Cl2NO2 由 14 个碳、11 个氢、2 个氯、1 个氮、2 个氧 组成。
别名/同义词：Diclofenac resinate · Diclofenac
Diclofenac resinate 的 CAS 登记号为 15307-86-5。
分子式 C14H11Cl2NO2，分子量 296.1。
别名/同义词：Diclofenac resinate、Diclofenac。
登记用途：Uses: MEDICATION、Use (kg) in Switzerland (2009): >5000、Use (kg、approx.) in Germany (2009): >75000、exact) in Germany (2009): 91583、Use (kg) in USA (2002): 9480、Use (kg) in France (2004): 9896、Consumption (g per capita) in Switzerland (2009): 0.64、Consumption (g per capita、approx.) in Germany (2009): 0.92、exact) in Germany (2009): 1.1、Consumption (g per capita) in the USA (2002): 0.034、Consumption (g per capita) in France (2004): 0.16、Excretion rate: 0.16、Calculated removal (%): 86.6、For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.、Use Classification: Pharmaceuticals -> Musculo-skeletal system -> Antiinflammatory and antirheumatic products -> Antiinflammatory and antirheumatic products、non-steroids -> Acetic acid derivatives and related substances、Pharmaceuticals、Methods of Manufacturing: Oxalyl chloride and 2、6-dichlorodiphenylamine are condensed to form the N、N-diphenyloxanilyl chloride that cyclizes under Friedel-Crafts conditions to yield 1-(2、6-diphenyl)isatin. Wolff-Kishner reduction of the 3-oxo group gives the lactam、which on hydrolysis affords the free acid. Neutralization with NaOH produces the salt.、Diclofenac sodium、Preparation: NL 6604752、A. Sallmann、R. Pfister、US 3558690 (1966、1971 both to Geigy)、Formulations、Preparations: Table: Diclofenac Sodium Combination Preparations [Table#6838]、Table: Diclofenac Potassium Preparations [Table#6839]、Table: Diclofenac Epolamine Preparations [Table#6840]、Table: Diclofenac Sodium Preparations [Table#6841]、Table: Diclofenac Preparations [Table#6842]、General Manufacturing Information: Synthesis: acylation of N-phenyl-2、6-dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide、which is fused with aluminum chloride to give 1-(2、6-dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.、Diclofenac Sodium、A Sallmann、R Pfister。
Diclofenac resinate（CAS 15307-86-5）的独立参考数据，整理自公开化学数据库。
| CAS Registry Number | 15307-86-5 |
|---|---|
| PubChem CID | 3033 |
| Molecular formula | C14H11Cl2NO2 |
| IUPAC name | 2-[2-(2,6-dichloroanilino)phenyl]acetic acid |
| UNII (FDA) | 144O8QL0L1 |
| Molecular Weight | 296.1 |
|---|---|
| XLogP3 | 4.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 295.0166840 |
| Monoisotopic Mass | 295.0166840 |
| Topological Polar Surface Area | 49.3 |
| Heavy Atom Count | 19 |
| Melting Point | 283-285 °C |
|---|---|
| Melting Point | 156-158 °C |
| Melting Point | 283 - 285 °C |
| Solubility | 2.37 |
| Solubility | In water, 2.37 mg/L at 25 °C |
| Solubility | 4.47e-03 g/L |
| LogP | 4.51 |
| LogP | log Kow = 4.51 |
| LogP | 3.9 |
| LogP | 4.26 |
diclofenac; 15307-86-5; Diclofenac acid; 2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid; Diclofenac free acid; Diclofenaco; Diclophenac; Diclofenacum; Zorvolex; Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-; 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid; Allvoran; DTXSID6022923; CHEBI:47381; Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-; [2-(2,6-Dichloroanilino)phenyl]acetic acid
| GHS notification summary | 29.2% (52 / 178) |
|---|
| GHS notification summary | 29.2% (52 / 178) |
|---|---|
| Reported hazard statements | H301 (30.3%), H302 (40.4%), H361 (21.3%), H372 (32%), H411 (51.1%) |
This chemical does not meet GHS hazard criteria for 29.2% (52 of 178) of reports.
H301 (30.3%): Toxic if swallowed [Danger Acute toxicity, oral]
Diclofenac resinate · CAS 15307-86-5 · C14H11Cl2NO2. UNII 144O8QL0L1. Melting Point: 283-285 °C; Melting Point: 156-158 °C; Melting Point: 283 - 285 °C.
数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。
English page: Diclofenac resinate