Diclofenac resinate (CAS 15307-86-5) — formula C14H11Cl2NO2, molecular weight 296.1.
| CAS Number | 15307-86-5 |
|---|---|
| Molecular Formula | C14H11Cl2NO2 |
| Molecular Weight | 296.1 |
| Melting Point | 283-285 °C |
| LogP | 4.51 |
| Applications | Uses: MEDICATION, Use (kg) in Switzerland (2009): >5000, Use (kg, approx.) in Germany (2009): >75000, exact) in Germany (2009): 91583, Use (kg) in USA (2002): 9480, Use (kg) in France (2004): 9896, Consumption (g per capita) in Switzerland (2009): 0.64, Consumption (g per capita, approx.) in Germany (2009): 0.92, exact) in Germany (2009): 1.1, Consumption (g per capita) in the USA (2002): 0.034, Consumption (g per capita) in France (2004): 0.16, Excretion rate: 0.16, Calculated removal (%): 86.6, For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis., Use Classification: Pharmaceuticals -> Musculo-skeletal system -> Antiinflammatory and antirheumatic products -> Antiinflammatory and antirheumatic products, non-steroids -> Acetic acid derivatives and related substances, Pharmaceuticals, Methods of Manufacturing: Oxalyl chloride and 2, 6-dichlorodiphenylamine are condensed to form the N, N-diphenyloxanilyl chloride that cyclizes under Friedel-Crafts conditions to yield 1-(2, 6-diphenyl)isatin. Wolff-Kishner reduction of the 3-oxo group gives the lactam, which on hydrolysis affords the free acid. Neutralization with NaOH produces the salt., Diclofenac sodium, Preparation: NL 6604752, A. Sallmann, R. Pfister, US 3558690 (1966, 1971 both to Geigy), Formulations, Preparations: Table: Diclofenac Sodium Combination Preparations [Table#6838], Table: Diclofenac Potassium Preparations [Table#6839], Table: Diclofenac Epolamine Preparations [Table#6840], Table: Diclofenac Sodium Preparations [Table#6841], Table: Diclofenac Preparations [Table#6842], General Manufacturing Information: Synthesis: acylation of N-phenyl-2, 6-dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2, 6-dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly., Diclofenac Sodium, A Sallmann, R Pfister |
Documented applications: Uses: MEDICATION, Use (kg) in Switzerland (2009): >5000, Use (kg, approx.) in Germany (2009): >75000, exact) in Germany (2009): 91583, Use (kg) in USA (2002): 9480, Use (kg) in France (2004): 9896, Consumption (g per capita) in Switzerland (2009): 0.64, Consumption (g per capita, approx.) in Germany (2009): 0.92, exact) in Germany (2009): 1.1, Consumption (g per capita) in the USA (2002): 0.034, Consumption (g per capita) in France (2004): 0.16, Excretion rate: 0.16, Calculated removal (%): 86.6, For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis., Use Classification: Pharmaceuticals -> Musculo-skeletal system -> Antiinflammatory and antirheumatic products -> Antiinflammatory and antirheumatic products, non-steroids -> Acetic acid derivatives and related substances, Pharmaceuticals, Methods of Manufacturing: Oxalyl chloride and 2, 6-dichlorodiphenylamine are condensed to form the N, N-diphenyloxanilyl chloride that cyclizes under Friedel-Crafts conditions to yield 1-(2, 6-diphenyl)isatin. Wolff-Kishner reduction of the 3-oxo group gives the lactam, which on hydrolysis affords the free acid. Neutralization with NaOH produces the salt., Diclofenac sodium, Preparation: NL 6604752, A. Sallmann, R. Pfister, US 3558690 (1966, 1971 both to Geigy), Formulations, Preparations: Table: Diclofenac Sodium Combination Preparations [Table#6838], Table: Diclofenac Potassium Preparations [Table#6839], Table: Diclofenac Epolamine Preparations [Table#6840], Table: Diclofenac Sodium Preparations [Table#6841], Table: Diclofenac Preparations [Table#6842], General Manufacturing Information: Synthesis: acylation of N-phenyl-2, 6-dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2, 6-dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly., Diclofenac Sodium, A Sallmann, R Pfister.
Diclofenac resinate is a chemical compound with CAS registry number 15307-86-5 and molecular formula C14H11Cl2NO2 (molecular weight 296.1).
CAS number: 15307-86-5
Its molecular formula C14H11Cl2NO2 comprises 14 C, 11 H, 2 Cl, 1 N, 2 O atoms.
Also known as: Diclofenac resinate · Diclofenac
The CAS registry number of Diclofenac resinate is 15307-86-5.
Molecular formula C14H11Cl2NO2, molecular weight 296.1.
It is also registered under: Diclofenac resinate, Diclofenac.
Recorded applications: Uses: MEDICATION, Use (kg) in Switzerland (2009): >5000, Use (kg, approx.) in Germany (2009): >75000, exact) in Germany (2009): 91583, Use (kg) in USA (2002): 9480, Use (kg) in France (2004): 9896, Consumption (g per capita) in Switzerland (2009): 0.64, Consumption (g per capita, approx.) in Germany (2009): 0.92, exact) in Germany (2009): 1.1, Consumption (g per capita) in the USA (2002): 0.034, Consumption (g per capita) in France (2004): 0.16, Excretion rate: 0.16, Calculated removal (%): 86.6, For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis., Use Classification: Pharmaceuticals -> Musculo-skeletal system -> Antiinflammatory and antirheumatic products -> Antiinflammatory and antirheumatic products, non-steroids -> Acetic acid derivatives and related substances, Pharmaceuticals, Methods of Manufacturing: Oxalyl chloride and 2, 6-dichlorodiphenylamine are condensed to form the N, N-diphenyloxanilyl chloride that cyclizes under Friedel-Crafts conditions to yield 1-(2, 6-diphenyl)isatin. Wolff-Kishner reduction of the 3-oxo group gives the lactam, which on hydrolysis affords the free acid. Neutralization with NaOH produces the salt., Diclofenac sodium, Preparation: NL 6604752, A. Sallmann, R. Pfister, US 3558690 (1966, 1971 both to Geigy), Formulations, Preparations: Table: Diclofenac Sodium Combination Preparations [Table#6838], Table: Diclofenac Potassium Preparations [Table#6839], Table: Diclofenac Epolamine Preparations [Table#6840], Table: Diclofenac Sodium Preparations [Table#6841], Table: Diclofenac Preparations [Table#6842], General Manufacturing Information: Synthesis: acylation of N-phenyl-2, 6-dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2, 6-dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly., Diclofenac Sodium, A Sallmann, R Pfister.
Independent reference data for Diclofenac resinate (CAS 15307-86-5), compiled from public chemistry databases.
| CAS Registry Number | 15307-86-5 |
|---|---|
| PubChem CID | 3033 |
| Molecular formula | C14H11Cl2NO2 |
| IUPAC name | 2-[2-(2,6-dichloroanilino)phenyl]acetic acid |
| UNII (FDA) | 144O8QL0L1 |
| Molecular Weight | 296.1 |
|---|---|
| XLogP3 | 4.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 295.0166840 |
| Monoisotopic Mass | 295.0166840 |
| Topological Polar Surface Area | 49.3 |
| Heavy Atom Count | 19 |
| Melting Point | 283-285 °C |
|---|---|
| Melting Point | 156-158 °C |
| Melting Point | 283 - 285 °C |
| Solubility | 2.37 |
| Solubility | In water, 2.37 mg/L at 25 °C |
| Solubility | 4.47e-03 g/L |
| LogP | 4.51 |
| LogP | log Kow = 4.51 |
| LogP | 3.9 |
| LogP | 4.26 |
diclofenac; 15307-86-5; Diclofenac acid; 2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid; Diclofenac free acid; Diclofenaco; Diclophenac; Diclofenacum; Zorvolex; Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-; 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid; Allvoran; DTXSID6022923; CHEBI:47381; Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-; [2-(2,6-Dichloroanilino)phenyl]acetic acid
| GHS notification summary | 29.2% (52 / 178) |
|---|
| GHS notification summary | 29.2% (52 / 178) |
|---|---|
| Reported hazard statements | H301 (30.3%), H302 (40.4%), H361 (21.3%), H372 (32%), H411 (51.1%) |
This chemical does not meet GHS hazard criteria for 29.2% (52 of 178) of reports.
H301 (30.3%): Toxic if swallowed [Danger Acute toxicity, oral]
Diclofenac resinate · CAS 15307-86-5 · C14H11Cl2NO2. UNII 144O8QL0L1. Melting Point: 283-285 °C; Melting Point: 156-158 °C; Melting Point: 283 - 285 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
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