desipramine

CAS 50-47-5C18H22N2MW 266.4

desipramine (CAS 50-47-5) — formula C18H22N2, molecular weight 266.4.

Product Overview

CAS Number	50-47-5
Molecular Formula	C18H22N2
Molecular Weight	266.4
Melting Point	214-218 °C
Boiling Point	172-174 °C @ 0.02 MM HG
LogP	4.9
Applications	Uses: Antidepressant, For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management., Use Classification: Pharmaceuticals, Methods of Manufacturing: FREE BASE & HYDROCHLORIDE: BRITISH PATENT 908, 788 (1962 TO GEIGY), Formulations, Preparations: DESIPRAMINE HYDROCHLORIDE, NF: NORPRAMIN, CAPSULES: 25, 50 MG, PERTOFRANE, TABLETS: 25, HYDROGEN CHLORIDE, FROM TABLE, General Manufacturing Information: PREPN OF HYDROCHLORIDE: BELGIAN PATENT 614, 616, CA 58 11338C (1963), (1962 TO GEIGY)

Applications

Documented applications: Uses: Antidepressant, For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management., Use Classification: Pharmaceuticals, Methods of Manufacturing: FREE BASE & HYDROCHLORIDE: BRITISH PATENT 908, 788 (1962 TO GEIGY), Formulations, Preparations: DESIPRAMINE HYDROCHLORIDE, NF: NORPRAMIN, CAPSULES: 25, 50 MG, PERTOFRANE, TABLETS: 25, HYDROGEN CHLORIDE, FROM TABLE, General Manufacturing Information: PREPN OF HYDROCHLORIDE: BELGIAN PATENT 614, 616, CA 58 11338C (1963), (1962 TO GEIGY).

Technical Profile

What this product is

desipramine is a chemical compound with CAS registry number 50-47-5 and molecular formula C18H22N2 (molecular weight 266.4).

Identification

CAS number: 50-47-5

Its molecular formula C18H22N2 comprises 18 C, 22 H, 2 N atoms.

Also known as: desipramine · 地昔帕明

Frequently Asked Questions

What is the CAS number of desipramine?

The CAS registry number of desipramine is 50-47-5.

What is the molecular formula and molecular weight of desipramine?

Molecular formula C18H22N2, molecular weight 266.4.

What other names is desipramine known by?

It is also registered under: desipramine, 地昔帕明.

What are the documented applications of desipramine?

Recorded applications: Uses: Antidepressant, For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management., Use Classification: Pharmaceuticals, Methods of Manufacturing: FREE BASE & HYDROCHLORIDE: BRITISH PATENT 908, 788 (1962 TO GEIGY), Formulations, Preparations: DESIPRAMINE HYDROCHLORIDE, NF: NORPRAMIN, CAPSULES: 25, 50 MG, PERTOFRANE, TABLETS: 25, HYDROGEN CHLORIDE, FROM TABLE, General Manufacturing Information: PREPN OF HYDROCHLORIDE: BELGIAN PATENT 614, 616, CA 58 11338C (1963), (1962 TO GEIGY).

PubChem Public Data

Independent reference data for desipramine (CAS 50-47-5), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	50-47-5
PubChem CID	2995
Molecular formula	C18H22N2
IUPAC name	3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
UNII (FDA)	TG537D343B

Computed descriptors

Molecular Weight	266.4
XLogP3	4.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	266.178298710
Monoisotopic Mass	266.178298710
Topological Polar Surface Area	15.3
Heavy Atom Count	20

Physicochemical values on record

Boiling Point	172-174 °C @ 0.02 MM HG
Melting Point	214-218 °C
Melting Point	214 - 218 °C
Solubility	58.6
Solubility	In water, 58.6 mg/l @ 24 °C.
Solubility	3.96e-02 g/L
LogP	4.9
LogP	log Kow = 4.90
LogP	3.7
LogP	4.0

Documented uses on record

Synonyms and trade names

desipramine; Norimipramine; 50-47-5; Desmethylimipramine; Monodemethylimipramine; Desipramin; Demethylimipramine; Desimipramine; Dimethylimipramine; Dezipramine; Desipramina; Methylaminopropyliminodibenzyl; Imipramine, demethyl-; desipraminum; Desimpramine; 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE

GHS hazard classification

Reported hazard statements	H302 (66.7%), H336 (66.7%), H370 (66.7%), H400 (33.3%)

H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H336 (66.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]

What the public record says

desipramine · CAS 50-47-5 · C18H22N2. UNII TG537D343B. Boiling Point: 172-174 °C @ 0.02 MM HG; Melting Point: 214-218 °C; Melting Point: 214 - 218 °C.

Physical description and handling notes

Source: PubChem / Wikidata; the batch COA governs where values differ.