Dasatinib

Description

Dasatinib · CAS 302962-49-8 · C22H26ClN7O2S. UNII X78UG0A0RN. Melting Point: 280-286 °C; Melting Point: 280 - 286 °C; Solubility: 1.28e-02 g/L.

Identification

CAS Registry Number	302962-49-8
PubChem CID	3062316
Molecular formula	C22H26ClN7O2S
IUPAC name	N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
UNII (FDA)	X78UG0A0RN

Computed Descriptors

Molecular Weight	488.0
XLogP3	3.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	487.1557220
Monoisotopic Mass	487.1557220
Topological Polar Surface Area	135
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Melting Point	280-286 °C
Melting Point	280 - 286 °C
Solubility	1.28e-02 g/L
LogP	1.8
LogP	3.41

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H301 (92.5%), H315 (77.5%), H318 (75%), H351 (80%), H360 (12.5%), H361 (80%), H371 (10%), H372 (80%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >10
• Consumption (g per capita; approx.) in Germany (2009): 0.000122
• Dasatinib is a selective tyrosine kinase receptor inhibitor that is used in the therapy of chronic myelogenous leukemia (CML) positive for the Philadelphia chromosome. Dasatinib is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
• Oral - Solid: 20 mg tablet; 50 mg tablet; 70 mg tablet; 80 mg tablet; 100 mg tablet; 140 mg tablet
• Chronic myeloid leukaemia, not elsewhere classified

Synonyms

Dasatinib; 302962-49-8; Sprycel; BMS-354825; Dasatinib anhydrous; BMS354825; Dasatinib (anhydrous); BMS 354825; dasatinibum; anh. dasatinib; anhydrous dasatinib; dasatinib (anh.); DTXSID4040979; BMS Dasatinib; X78UG0A0RN; NSC732517

Frequently Asked Questions

What are the CAS number and molecular formula of Dasatinib?

CAS 302962-49-8; molecular formula C22H26ClN7O2S; molecular weight — g/mol.

What other names is Dasatinib known by?

Dasatinib, 302962-49-8, Sprycel, BMS-354825, Dasatinib anhydrous, BMS354825.

Is Dasatinib classified as hazardous?

Hazard statements reported: H301, H315, H318, H351, H360.

What are the key physical properties of Dasatinib?

Melting Point: 280-286 °C; Melting Point: 280 - 286 °C; Solubility: 1.28e-02 g/L; LogP: 1.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.