甲磺酸达拉非尼

Name: 甲磺酸达拉非尼
Brand: 济南圣和化工有限公司

CAS 1195768-06-9C23H20F3N5O2S2MW 519.6

济南圣和化工主营供应甲磺酸达拉非尼（CAS 1195768-06-9），归类于医药中间体及原料药，分子式 C23H20F3N5O2S2，分子量 519.6。我们面向国内化工贸易与生产企业提供稳定的现货供应，报价响应快，支持对公转账并可开具增值税发票。

产品概览

CAS号	1195768-06-9
分子式	C23H20F3N5O2S2
分子量	519.6
沸点	653.7
LogP	2.9
纯度	按批次COA提供(不公开发布)
包装	按订单/批次确认(不公开发布)
应用领域	医药中间体及原料药
类别	医药中间体及原料药

应用领域

医药中间体及原料药

该产品的下游应用集中在医药中间体及原料药。不同客户工艺差异较大，我们支持按需提供样品与小批量试用。

包装与储存

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

运输常规化工运输

样品可协商提供

交期现货/按订单安排

供应说明：甲磺酸达拉非尼常规包装为按订单/批次确认(不公开发布)，储存时应密封置于阴凉干燥处，避免与氧化剂混放。济南圣和化工有限公司支持国内物流发货，大货交期与运费以订单确认为准。

质量与文件

每批产品随货提供 COA（分析证书）；可按需提供 MSDS/技术数据表及第三方检测报告。纯度与包装以批次 COA 及订单确认为准。

关于供应商

济南圣和化工有限公司位于山东济南，主营化工原料供应，精选产品 2,000+ 种，覆盖有机化学品、无机化学品、食品添加剂、医药中间体等 12 大分类。我们随货提供 COA 分析证书，一个工作日内回复报价，欢迎国内外采购方长期合作。

常见问题

甲磺酸达拉非尼的 CAS 号是多少？

甲磺酸达拉非尼的 CAS 号为 1195768-06-9。

该产品的纯度和包装规格是什么？

常规纯度规格为按批次COA提供(不公开发布)，包装为按订单/批次确认(不公开发布)，随货提供 COA。

甲磺酸达拉非尼有什么用途？

主要应用于医药中间体及原料药。

如何购买或获取报价？

请发送邮件至 info@591daili.com 或通过 WhatsApp 联系，注明产品名称、CAS 号与需求数量，一个工作日内回复报价。供应商：济南圣和化工有限公司。

PubChem 公开数据

Description

dabrafenib mesylate · CAS 1195768-06-9 · C23H20F3N5O2S2. UNII QGP4HA4G1B. Boiling Point: 653.7; LogP: 2.9; Dissociation Constants: -1.5.

Identification

CAS Registry Number	1195768-06-9
PubChem CID	44462760
Molecular formula	C23H20F3N5O2S2
IUPAC name	N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
UNII (FDA)	QGP4HA4G1B

Computed Descriptors

Molecular Weight	519.6
XLogP3	4.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	6
Exact Mass	519.10105173
Monoisotopic Mass	519.10105173
Topological Polar Surface Area	147
Heavy Atom Count	35
Formal Charge	0

Physical & Chemical Properties

Boiling Point	653.7
LogP	2.9
Dissociation Constants	-1.5

Physical description & handling notes

very slightly soluble at pH 1

GHS Hazard Classification

Reported hazard statements	H361 (22.2%), H373 (88.9%), H400 (100%), H410 (11.1%), H411 (88.9%)

H361 (22.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

H361fd (77.8%): Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]

Documented Uses

Dabrafenib is a selective inhibitor of mutated forms of BRAF kinase and is used alone or in combination with trametinib in the treatment of advanced malignant melanoma. Dabrafenib therapy is associated with transient elevations in serum aminotransferase during therapy, but has not been linked to instances of clinically apparent acute liver injury.
Breast Feeding; Lactation; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors;
Avoid grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum levels of dabrafenib.
Avoid St. John's Wort. This herb induces CYP3A4 metabolism, which may reduce serum levels of dabrafenib.
Do not take with or immediately after a high-fat meal. Dabrafenib's bioavailability is reduced when taken with a high-fat meal.
Take on an empty stomach. Take dabrafenib at least one hour before or two hours after a meal.

Synonyms

Dabrafenib; 1195765-45-7; GSK2118436A; GSK2118436; GSK-2118436; GSK-2118436A; QGP4HA4G1B; CHEBI:75045; DTXSID20152499; N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; N-(3-(5-(2-AMINOPYRIMIDIN-4-YL)-2-TERT-BUTYL-1,3-THIAZOL-4-YL)-2-FLUOROPHENYL)-2,6-DIFLUOROBENZENESULFONAMIDE; N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide; dabrafenibum; RefChem:58040; DTXCID8074990; BRAF Inhibitor GSK2118436

Frequently Asked Questions

What are the CAS number and molecular formula of dabrafenib mesylate?

CAS 1195768-06-9; molecular formula C23H20F3N5O2S2; molecular weight — g/mol.

What other names is dabrafenib mesylate known by?

Dabrafenib, 1195765-45-7, GSK2118436A, GSK2118436, GSK-2118436, GSK-2118436A.

Is dabrafenib mesylate classified as hazardous?

Hazard statements reported: H361, H373, H400, H410, H411.

What are the key physical properties of dabrafenib mesylate?

Boiling Point: 653.7; LogP: 2.9; Dissociation Constants: -1.5.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.