Cyclophosphamide monohydrate (CAS 6055-19-2) — formula C7H15Cl2N2O2P, molecular weight 261.08.
| CAS Number | 6055-19-2 |
|---|---|
| Molecular Formula | C7H15Cl2N2O2P |
| Molecular Weight | 261.08 |
| Melting Point | 106 to 113 °F (NTP, 1992) |
| Boiling Point | 336 °C |
| LogP | 0.6 |
| Applications | Uses: Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug, [Merck Index] An alkylating agent, [HSDB], Therap Cat: Antineoplastic, Immunosupressive, Antineoplastic for treatment of leukemia, etc, tested for use in chemical shearing of sheep and as an insect chemosterilant., MEDICATION, MEDICATION (VET), Use (kg) in Switzerland (2009): >25, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 252, Consumption (g per capita) in Switzerland (2009): 0.0032, Consumption (g per capita, approx.) in Germany (2009): 0.0031, exact) in Germany (2009): 0.0031, Excretion rate: 0.2, Calculated removal (%): 22, Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients., Methods of Manufacturing: Cyclophosphamide can be prepared by treating N, N-bis(B-chloroethyl)-phosphamide dichloride with propanolamine in the presence of trimethylamine and dioxane., Prepn: H. Arnold et al., Naturwiss 45, 64 (1957), eidem, Nature 181, 931 (1958), H. Arnold, F. Bourseaux, Angew Chem. 70, 539 (1958)., Formulations, Preparations: CYCLOPHOSPHAMIDE IS SUPPLIED AS 25 & 50 MG TABLETS & AS A POWDER (100 TO 2000 MG) IN STERILE VIALS., Grade: USP, measured as containing 95.0 - 105.0% active ingredient calculated as the monohydrate, 5.7 - 6.8% max. water content, 0.002% max. heavy metals, and producing an aqueous solution (1 in 100) at pH 3.9 - 7.1., Available as 25 and 50 mg tablets ... and in vials for injection in amounts of 100, 200 or 500 mg measured as containing 90.0 - 110.0% of the stated amount of anhydrous cyclophosphamide., Consumption Patterns: Total US sales are 600 kg, year (1975), U.S. Production: Not produced in the US., U.S. Imports: No data were available on the quantities imported. |
Documented applications: Uses: Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug, [Merck Index] An alkylating agent, [HSDB], Therap Cat: Antineoplastic, Immunosupressive, Antineoplastic for treatment of leukemia, etc, tested for use in chemical shearing of sheep and as an insect chemosterilant., MEDICATION, MEDICATION (VET), Use (kg) in Switzerland (2009): >25, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 252, Consumption (g per capita) in Switzerland (2009): 0.0032, Consumption (g per capita, approx.) in Germany (2009): 0.0031, exact) in Germany (2009): 0.0031, Excretion rate: 0.2, Calculated removal (%): 22, Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients., Methods of Manufacturing: Cyclophosphamide can be prepared by treating N, N-bis(B-chloroethyl)-phosphamide dichloride with propanolamine in the presence of trimethylamine and dioxane., Prepn: H. Arnold et al., Naturwiss 45, 64 (1957), eidem, Nature 181, 931 (1958), H. Arnold, F. Bourseaux, Angew Chem. 70, 539 (1958)., Formulations, Preparations: CYCLOPHOSPHAMIDE IS SUPPLIED AS 25 & 50 MG TABLETS & AS A POWDER (100 TO 2000 MG) IN STERILE VIALS., Grade: USP, measured as containing 95.0 - 105.0% active ingredient calculated as the monohydrate, 5.7 - 6.8% max. water content, 0.002% max. heavy metals, and producing an aqueous solution (1 in 100) at pH 3.9 - 7.1., Available as 25 and 50 mg tablets ... and in vials for injection in amounts of 100, 200 or 500 mg measured as containing 90.0 - 110.0% of the stated amount of anhydrous cyclophosphamide., Consumption Patterns: Total US sales are 600 kg, year (1975), U.S. Production: Not produced in the US., U.S. Imports: No data were available on the quantities imported..
Cyclophosphamide monohydrate is a chemical compound with CAS registry number 6055-19-2 and molecular formula C7H15Cl2N2O2P (molecular weight 261.08).
CAS number: 6055-19-2
Its molecular formula C7H15Cl2N2O2P comprises 7 C, 15 H, 2 Cl, 2 N, 2 O, 1 P atoms.
Also known as: Cyclophosphamide monohydrate · 环磷酰胺一水合物
The CAS registry number of Cyclophosphamide monohydrate is 6055-19-2.
Molecular formula C7H15Cl2N2O2P, molecular weight 261.08.
It is also registered under: Cyclophosphamide monohydrate, 环磷酰胺一水合物.
Recorded applications: Uses: Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug, [Merck Index] An alkylating agent, [HSDB], Therap Cat: Antineoplastic, Immunosupressive, Antineoplastic for treatment of leukemia, etc, tested for use in chemical shearing of sheep and as an insect chemosterilant., MEDICATION, MEDICATION (VET), Use (kg) in Switzerland (2009): >25, Use (kg, approx.) in Germany (2009): >250, exact) in Germany (2009): 252, Consumption (g per capita) in Switzerland (2009): 0.0032, Consumption (g per capita, approx.) in Germany (2009): 0.0031, exact) in Germany (2009): 0.0031, Excretion rate: 0.2, Calculated removal (%): 22, Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients., Methods of Manufacturing: Cyclophosphamide can be prepared by treating N, N-bis(B-chloroethyl)-phosphamide dichloride with propanolamine in the presence of trimethylamine and dioxane., Prepn: H. Arnold et al., Naturwiss 45, 64 (1957), eidem, Nature 181, 931 (1958), H. Arnold, F. Bourseaux, Angew Chem. 70, 539 (1958)., Formulations, Preparations: CYCLOPHOSPHAMIDE IS SUPPLIED AS 25 & 50 MG TABLETS & AS A POWDER (100 TO 2000 MG) IN STERILE VIALS., Grade: USP, measured as containing 95.0 - 105.0% active ingredient calculated as the monohydrate, 5.7 - 6.8% max. water content, 0.002% max. heavy metals, and producing an aqueous solution (1 in 100) at pH 3.9 - 7.1., Available as 25 and 50 mg tablets ... and in vials for injection in amounts of 100, 200 or 500 mg measured as containing 90.0 - 110.0% of the stated amount of anhydrous cyclophosphamide., Consumption Patterns: Total US sales are 600 kg, year (1975), U.S. Production: Not produced in the US., U.S. Imports: No data were available on the quantities imported..
Independent reference data for Cyclophosphamide monohydrate (CAS 6055-19-2), compiled from public chemistry databases.
| CAS Registry Number | 6055-19-2 |
|---|---|
| PubChem CID | 2907 |
| Molecular formula | C7H15Cl2N2O2P |
| IUPAC name | N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine |
| UNII (FDA) | 6UXW23996M |
| Molecular Weight | 261.08 |
|---|---|
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 260.0248201 |
| Monoisotopic Mass | 260.0248201 |
| Topological Polar Surface Area | 41.6 |
| Heavy Atom Count | 14 |
| Boiling Point | 336 °C |
|---|---|
| Melting Point | 106 to 113 °F (NTP, 1992) |
| Melting Point | 48-49 |
| Melting Point | 49.5-53 °C |
| Melting Point | 41 - 45 °C |
| Melting Point | 49.5 - 53 °C |
| Flash Point | 113 °C c.c. |
| Solubility | 10 to 50 mg/mL at 73 °F (NTP, 1992) |
| Solubility | Soluble. 1-5 g/100 mL at 23 °C |
| Solubility | In water, 40,000 ppm @ 20 °C |
cyclophosphamide; 50-18-0; Cytoxan; Cyclophosphamid; Cyclophosphane; Clafen; Endoxan; Cyclophosphan; Cytophosphan; Procytox; Sendoxan; Cyclophosphamidum; Claphene; Cyclostin; Endoxana; Endoxanal
| Reported hazard statements | H301 (63.2%), H302 (35.3%), H318 (36.8%), H340 (95.6%), H350 (98.5%), H360 (94.1%), H372 (36.8%), H362 |
|---|
H301 (63.2%): Toxic if swallowed [Danger Acute toxicity, oral]
H302 (35.3%): Harmful if swallowed [Warning Acute toxicity, oral]
Cyclophosphamide monohydrate · CAS 6055-19-2 · C7H15Cl2N2O2P. UNII 6UXW23996M. Boiling Point: 336 °C; Melting Point: 106 to 113 °F (NTP, 1992); Melting Point: 48-49.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 环磷酰胺一水合物