Cycloheximide (CAS 4630-75-5) — formula C15H23NO4, molecular weight 281.35.
| CAS Number | 4630-75-5 |
|---|---|
| Molecular Formula | C15H23NO4 |
| Molecular Weight | 281.35 |
| Melting Point | 247 to 250 °F (EPA, 1998) |
| LogP | log Kow = 0.55 |
| Applications | Uses: Antibiotic compound isolated from Streptomyces griseus, [Merck Index] Used as a fungicide, plant growth regulator, protein synthesis inhibitor, and to stimulate the natural abscission process (pre-harvest use on citrus), [HSDB], Farming (Pesticides) [Category: Industry], For Cycloheximide (USEPA, OPP Pesticide Code: 043401) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., Fungicide, as protein synthesis inhibitor, Cycloheximide, is used in laboratory media as a selective agent to permit isolation of pathogenic and non-pathogenic fungi from specimens such as sputa and feces which may be other fungi., Cycloheximide has a limited application in treatment of downy mildew of onions and shoot blight of Japanese larch., For more Uses (Complete) data for CYCLOHEXIMIDE (8 total), please visit the HSDB record page., Methods of Manufacturing: Antibiotic substance isolated from beers of streptomycin-producing strains of Streptomyces griseus: Leach et al, J Am Chem Soc 69, 474 (1947), Ford, Leach, J Am Chem Soc 70, 1223 (1948), Whiffen et al, US patent 2, 574, 519 (1951 to Upjohn). Production, assay and antibiotic activity: Whiffen, J Bacteriol 56, 283 (1948). Improved production method: Kominek, US patents 3, 915, 802-3 (both 1975 to Upjohn). ... synthesis of dl- and l-forms: Johnson et al, J Am Chem Soc 88, 149 (1966)., Formulations, Preparations: USEPA, OPP Pesticide Code 043401, Trade Names: Acti-dione, Acti-aid, ENT-15541, Acti-dione BR, Acti-dione PM, Actispray, Hizarocin, Kaken, Naramycin A, NSC-185, U 4527., Discontinued names: Acti-Aid, Acti-dione, ... Actispray, 7.7% WETTABLE POWDER, ACTI-DIONE FERRATED (UPJOHN) 4% WT, WT CYCLOHEXIMIDE, 96% EXSICCATED FERROUS SULFATE USED FOR TREATMENT OF TURF. ACTI-DIONE THIRAM (0.75%, 75.00% & 24.25% INERT INGREDIENTS) TURF FUNGICIDE, ACTI-DIONE PM (0.027%) POWDERY MILDEW CONTROL ON ORNAMENTALS. ACTI-AID CITRUS ABSCISSION AGENT (COMPONENT A 4.22% WT, WT WATER SOL FORMULATION AND A SEPARATE COMPONENT B- SURFACTANT)., This ... compound is ... formulated as an oily soln ... & water-sol tablets., For more Formulations, Preparations (Complete) data for CYCLOHEXIMIDE (21 total), General Manufacturing Information: ..., is recovered as a byproduct during streptomycin manufacturing through fermentation. |
Documented applications: Uses: Antibiotic compound isolated from Streptomyces griseus, [Merck Index] Used as a fungicide, plant growth regulator, protein synthesis inhibitor, and to stimulate the natural abscission process (pre-harvest use on citrus), [HSDB], Farming (Pesticides) [Category: Industry], For Cycloheximide (USEPA, OPP Pesticide Code: 043401) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., Fungicide, as protein synthesis inhibitor, Cycloheximide, is used in laboratory media as a selective agent to permit isolation of pathogenic and non-pathogenic fungi from specimens such as sputa and feces which may be other fungi., Cycloheximide has a limited application in treatment of downy mildew of onions and shoot blight of Japanese larch., For more Uses (Complete) data for CYCLOHEXIMIDE (8 total), please visit the HSDB record page., Methods of Manufacturing: Antibiotic substance isolated from beers of streptomycin-producing strains of Streptomyces griseus: Leach et al, J Am Chem Soc 69, 474 (1947), Ford, Leach, J Am Chem Soc 70, 1223 (1948), Whiffen et al, US patent 2, 574, 519 (1951 to Upjohn). Production, assay and antibiotic activity: Whiffen, J Bacteriol 56, 283 (1948). Improved production method: Kominek, US patents 3, 915, 802-3 (both 1975 to Upjohn). ... synthesis of dl- and l-forms: Johnson et al, J Am Chem Soc 88, 149 (1966)., Formulations, Preparations: USEPA, OPP Pesticide Code 043401, Trade Names: Acti-dione, Acti-aid, ENT-15541, Acti-dione BR, Acti-dione PM, Actispray, Hizarocin, Kaken, Naramycin A, NSC-185, U 4527., Discontinued names: Acti-Aid, Acti-dione, ... Actispray, 7.7% WETTABLE POWDER, ACTI-DIONE FERRATED (UPJOHN) 4% WT, WT CYCLOHEXIMIDE, 96% EXSICCATED FERROUS SULFATE USED FOR TREATMENT OF TURF. ACTI-DIONE THIRAM (0.75%, 75.00% & 24.25% INERT INGREDIENTS) TURF FUNGICIDE, ACTI-DIONE PM (0.027%) POWDERY MILDEW CONTROL ON ORNAMENTALS. ACTI-AID CITRUS ABSCISSION AGENT (COMPONENT A 4.22% WT, WT WATER SOL FORMULATION AND A SEPARATE COMPONENT B- SURFACTANT)., This ... compound is ... formulated as an oily soln ... & water-sol tablets., For more Formulations, Preparations (Complete) data for CYCLOHEXIMIDE (21 total), General Manufacturing Information: ..., is recovered as a byproduct during streptomycin manufacturing through fermentation..
Cycloheximide is a chemical compound with CAS registry number 4630-75-5 and molecular formula C15H23NO4 (molecular weight 281.35).
CAS number: 4630-75-5
Its molecular formula C15H23NO4 comprises 15 C, 23 H, 1 N, 4 O atoms.
Also known as: Cycloheximide · 放线菌酮
The CAS registry number of Cycloheximide is 4630-75-5.
Molecular formula C15H23NO4, molecular weight 281.35.
It is also registered under: Cycloheximide, 放线菌酮.
Recorded applications: Uses: Antibiotic compound isolated from Streptomyces griseus, [Merck Index] Used as a fungicide, plant growth regulator, protein synthesis inhibitor, and to stimulate the natural abscission process (pre-harvest use on citrus), [HSDB], Farming (Pesticides) [Category: Industry], For Cycloheximide (USEPA, OPP Pesticide Code: 043401) there are 0 labels match., SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses., Fungicide, as protein synthesis inhibitor, Cycloheximide, is used in laboratory media as a selective agent to permit isolation of pathogenic and non-pathogenic fungi from specimens such as sputa and feces which may be other fungi., Cycloheximide has a limited application in treatment of downy mildew of onions and shoot blight of Japanese larch., For more Uses (Complete) data for CYCLOHEXIMIDE (8 total), please visit the HSDB record page., Methods of Manufacturing: Antibiotic substance isolated from beers of streptomycin-producing strains of Streptomyces griseus: Leach et al, J Am Chem Soc 69, 474 (1947), Ford, Leach, J Am Chem Soc 70, 1223 (1948), Whiffen et al, US patent 2, 574, 519 (1951 to Upjohn). Production, assay and antibiotic activity: Whiffen, J Bacteriol 56, 283 (1948). Improved production method: Kominek, US patents 3, 915, 802-3 (both 1975 to Upjohn). ... synthesis of dl- and l-forms: Johnson et al, J Am Chem Soc 88, 149 (1966)., Formulations, Preparations: USEPA, OPP Pesticide Code 043401, Trade Names: Acti-dione, Acti-aid, ENT-15541, Acti-dione BR, Acti-dione PM, Actispray, Hizarocin, Kaken, Naramycin A, NSC-185, U 4527., Discontinued names: Acti-Aid, Acti-dione, ... Actispray, 7.7% WETTABLE POWDER, ACTI-DIONE FERRATED (UPJOHN) 4% WT, WT CYCLOHEXIMIDE, 96% EXSICCATED FERROUS SULFATE USED FOR TREATMENT OF TURF. ACTI-DIONE THIRAM (0.75%, 75.00% & 24.25% INERT INGREDIENTS) TURF FUNGICIDE, ACTI-DIONE PM (0.027%) POWDERY MILDEW CONTROL ON ORNAMENTALS. ACTI-AID CITRUS ABSCISSION AGENT (COMPONENT A 4.22% WT, WT WATER SOL FORMULATION AND A SEPARATE COMPONENT B- SURFACTANT)., This ... compound is ... formulated as an oily soln ... & water-sol tablets., For more Formulations, Preparations (Complete) data for CYCLOHEXIMIDE (21 total), General Manufacturing Information: ..., is recovered as a byproduct during streptomycin manufacturing through fermentation..
Independent reference data for Cycloheximide (CAS 4630-75-5), compiled from public chemistry databases.
| CAS Registry Number | 4630-75-5 |
|---|---|
| PubChem CID | 6197 |
| Molecular formula | C15H23NO4 |
| IUPAC name | 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione |
| UNII (FDA) | 98600C0908 |
| Molecular Weight | 281.35 |
|---|---|
| XLogP3 | 0.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 281.16270821 |
| Monoisotopic Mass | 281.16270821 |
| Topological Polar Surface Area | 83.5 |
| Heavy Atom Count | 20 |
| Melting Point | 247 to 250 °F (EPA, 1998) |
|---|---|
| Melting Point | 119.5-121 °C; also listed as 115-16 °C |
| Melting Point | 119.5-121 °C |
| Solubility | 10 to 50 mg/mL at 68 °F (NTP, 1992) |
| Solubility | In water, 2.1X10-4 mg/l @ 25 °C |
| Vapor Pressure | 0.006 [mm Hg] @25 °C |
| LogP | log Kow = 0.55 |
| LogP | 0.55 |
cycloheximide; 66-81-9; ACTIDIONE; Cicloheximide; NARAMYCIN A; Actidion; Hizarocin; Naramycin; Kaken; Acti-Aid; Actidone; Neocycloheximide; Cicloheximida; Actispray; Acti-Dione; Actidione PM
| Reported hazard statements | H300, H341, H411, H315 (38.4%), H360 (69.7%), H319 |
|---|
H300: Fatal if swallowed [Danger Acute toxicity, oral]
H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]
Cycloheximide · CAS 4630-75-5 · C15H23NO4. UNII 98600C0908. Melting Point: 247 to 250 °F (EPA, 1998); Melting Point: 119.5-121 °C; also listed as 115-16 °C; Melting Point: 119.5-121 °C.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 放线菌酮