Cyclohexasiloxane (CAS 540-97-6) — formula C12H36O6Si6, molecular weight 444.92.
| CAS Number | 540-97-6 |
|---|---|
| Molecular Formula | C12H36O6Si6 |
| Molecular Weight | 444.92 |
| Melting Point | -3 °C |
| Boiling Point | 245 °C |
| LogP | log Kow = 8.87 |
| Applications | Uses: Electronics, furniture, health-care products, cookware, and medical devices, Field of application: Surface treatments, paint, lacquers, and varnishes., From table, Cyclomethicone formulation containing dodecamethylcyclohexasiloxane (D6), decamethylcyclopentasiloxane (D5), and octamethylcyclotetrasiloxane (D4) are used in consumer products such as body lotion, hair styling products, lipstick, and deodorants., Limited number of applications including some cosmetics, where it provides certain application-related benefits preferred by customers, The most important use, worldwide and in Canada, of D6 is as an ingredient in the formulation of personal care products and as an intermediate in the production of polydimethylsiloxanes (PDMS) silicone polymers ... D6 is also a constituent of cyclomethicone in the cosmetics industry ... In Canada, the most important uses of the mixtures of low molecular weight volatile cyclic siloxanes, which may contain a certain percentage of D6, are in the preparation of personal care products including hair and skin care products, and antiperspirants ... D6 was reported for use as a defoamer ... Defoamers are employed often at parts per million levels in a range of processing industries including pulp and paper, food, petrochemical, petroleum, and chemical manufacture as well as water treatment. Silicones are also used as defoamers in household products such as cleaners and detergents., Use Classification: Cosmetics -> Emollient, Solvent, Hair conditioning, Industry Uses: Monomers, Intermediate, Viscosity modifiers, Diluent, Consumer Uses: Diluent, Household Products: Cosmetics product ingredient: Dodecamethylcyclohexasiloxane (D6) (Cyclohexasiloxane), Reason for Listing:, - Identified as Persistent, Bioaccumulative, and Inherently Toxic to the environment by the Canadian Environmental Protection Act Environmental Registry Domestic Substances List, - Priority Chemical identified under the California Environmental Contaminant Biomonitoring Program, - Included in the European Union candidate list of Substances of Very High Concern in accordance with Article 59 of Regulation (EC) 1907, 2006 on the basis of Article 57(d), Article 57(e), or Article 57(f) for persistent, bioaccumulative and toxic, or very persistent and very bioaccumulative properties, Potential Health Impacts: Bioaccumulation, Endocrine Toxicity, Environmental Persistence, Hepatotoxicity and Digestive System Toxicity, and Reproductive Toxicity, Product count: 198, Information on 10 consumer products that contain Dodecamethylcyclohexasiloxane in the following categories is provided:, • Auto Products, • Personal Care, Methods of Manufacturing: Isolated from the hydrolysis product of dimethyldichlorosilane, Formulations, Preparations: Typically including dodecamethylcyclohexasiloxane (D6) with a general formula of (-Si(CH3)2O-)x in a cyclic configuration, where x is generally less than 8, and more commonly x is 3-7. This formulation is commonly used in cosmetics., U.S. Production: 2023: 5, 500, 000 - <7, 000, 000 lb, 2022: 5, 2021: 7, 000 - <8, 2020: 5, Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7388], Cyclohexasiloxane, dodecamethyl- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Cyclohexasiloxane, 2, 4, 6, 8, 10, 12, 12-dodecamethyl-. National Production Volume: 1, 000 - 10, yr., General Manufacturing Information: Plastics Product Manufacturing, All Other Basic Inorganic Chemical Manufacturing, Other (requires additional information), Paint and Coating Manufacturing, All Other Chemical Product and Preparation Manufacturing, 12-dodecamethyl-: ACTIVE, Cyclomethicone, is a common name for a mixture of cyclic dimethyl siloxanes, Cyclomethicone is a generic name for several cyclic dimethyl polysiloxane compounds ... it refers not only to octamethylcyclotetrasiloxane (D4), but also to cyclotrisiloxane (D3), cyclopentasiloxane (D5), cyclohexasiloxane (D6), and cycloheptasiloxane (D7), i.e. compounds of the general formula (CH3)2n-(O)n-(Si)n where n = 3-7. |
Documented applications: Uses: Electronics, furniture, health-care products, cookware, and medical devices, Field of application: Surface treatments, paint, lacquers, and varnishes., From table, Cyclomethicone formulation containing dodecamethylcyclohexasiloxane (D6), decamethylcyclopentasiloxane (D5), and octamethylcyclotetrasiloxane (D4) are used in consumer products such as body lotion, hair styling products, lipstick, and deodorants., Limited number of applications including some cosmetics, where it provides certain application-related benefits preferred by customers, The most important use, worldwide and in Canada, of D6 is as an ingredient in the formulation of personal care products and as an intermediate in the production of polydimethylsiloxanes (PDMS) silicone polymers ... D6 is also a constituent of cyclomethicone in the cosmetics industry ... In Canada, the most important uses of the mixtures of low molecular weight volatile cyclic siloxanes, which may contain a certain percentage of D6, are in the preparation of personal care products including hair and skin care products, and antiperspirants ... D6 was reported for use as a defoamer ... Defoamers are employed often at parts per million levels in a range of processing industries including pulp and paper, food, petrochemical, petroleum, and chemical manufacture as well as water treatment. Silicones are also used as defoamers in household products such as cleaners and detergents., Use Classification: Cosmetics -> Emollient, Solvent, Hair conditioning, Industry Uses: Monomers, Intermediate, Viscosity modifiers, Diluent, Consumer Uses: Diluent, Household Products: Cosmetics product ingredient: Dodecamethylcyclohexasiloxane (D6) (Cyclohexasiloxane), Reason for Listing:, - Identified as Persistent, Bioaccumulative, and Inherently Toxic to the environment by the Canadian Environmental Protection Act Environmental Registry Domestic Substances List, - Priority Chemical identified under the California Environmental Contaminant Biomonitoring Program, - Included in the European Union candidate list of Substances of Very High Concern in accordance with Article 59 of Regulation (EC) 1907, 2006 on the basis of Article 57(d), Article 57(e), or Article 57(f) for persistent, bioaccumulative and toxic, or very persistent and very bioaccumulative properties, Potential Health Impacts: Bioaccumulation, Endocrine Toxicity, Environmental Persistence, Hepatotoxicity and Digestive System Toxicity, and Reproductive Toxicity, Product count: 198, Information on 10 consumer products that contain Dodecamethylcyclohexasiloxane in the following categories is provided:, • Auto Products, • Personal Care, Methods of Manufacturing: Isolated from the hydrolysis product of dimethyldichlorosilane, Formulations, Preparations: Typically including dodecamethylcyclohexasiloxane (D6) with a general formula of (-Si(CH3)2O-)x in a cyclic configuration, where x is generally less than 8, and more commonly x is 3-7. This formulation is commonly used in cosmetics., U.S. Production: 2023: 5, 500, 000 - <7, 000, 000 lb, 2022: 5, 2021: 7, 000 - <8, 2020: 5, Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7388], Cyclohexasiloxane, dodecamethyl- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Cyclohexasiloxane, 2, 4, 6, 8, 10, 12, 12-dodecamethyl-. National Production Volume: 1, 000 - 10, yr., General Manufacturing Information: Plastics Product Manufacturing, All Other Basic Inorganic Chemical Manufacturing, Other (requires additional information), Paint and Coating Manufacturing, All Other Chemical Product and Preparation Manufacturing, 12-dodecamethyl-: ACTIVE, Cyclomethicone, is a common name for a mixture of cyclic dimethyl siloxanes, Cyclomethicone is a generic name for several cyclic dimethyl polysiloxane compounds ... it refers not only to octamethylcyclotetrasiloxane (D4), but also to cyclotrisiloxane (D3), cyclopentasiloxane (D5), cyclohexasiloxane (D6), and cycloheptasiloxane (D7), i.e. compounds of the general formula (CH3)2n-(O)n-(Si)n where n = 3-7..
Cyclohexasiloxane is a chemical compound with CAS registry number 540-97-6 and molecular formula C12H36O6Si6 (molecular weight 444.92).
CAS number: 540-97-6
Its molecular formula C12H36O6Si6 comprises 12 C, 36 H, 6 O, 6 Si atoms.
Also known as: Cyclohexasiloxane · 环六硅氧烷
The CAS registry number of Cyclohexasiloxane is 540-97-6.
Molecular formula C12H36O6Si6, molecular weight 444.92.
It is also registered under: Cyclohexasiloxane, 环六硅氧烷.
Recorded applications: Uses: Electronics, furniture, health-care products, cookware, and medical devices, Field of application: Surface treatments, paint, lacquers, and varnishes., From table, Cyclomethicone formulation containing dodecamethylcyclohexasiloxane (D6), decamethylcyclopentasiloxane (D5), and octamethylcyclotetrasiloxane (D4) are used in consumer products such as body lotion, hair styling products, lipstick, and deodorants., Limited number of applications including some cosmetics, where it provides certain application-related benefits preferred by customers, The most important use, worldwide and in Canada, of D6 is as an ingredient in the formulation of personal care products and as an intermediate in the production of polydimethylsiloxanes (PDMS) silicone polymers ... D6 is also a constituent of cyclomethicone in the cosmetics industry ... In Canada, the most important uses of the mixtures of low molecular weight volatile cyclic siloxanes, which may contain a certain percentage of D6, are in the preparation of personal care products including hair and skin care products, and antiperspirants ... D6 was reported for use as a defoamer ... Defoamers are employed often at parts per million levels in a range of processing industries including pulp and paper, food, petrochemical, petroleum, and chemical manufacture as well as water treatment. Silicones are also used as defoamers in household products such as cleaners and detergents., Use Classification: Cosmetics -> Emollient, Solvent, Hair conditioning, Industry Uses: Monomers, Intermediate, Viscosity modifiers, Diluent, Consumer Uses: Diluent, Household Products: Cosmetics product ingredient: Dodecamethylcyclohexasiloxane (D6) (Cyclohexasiloxane), Reason for Listing:, - Identified as Persistent, Bioaccumulative, and Inherently Toxic to the environment by the Canadian Environmental Protection Act Environmental Registry Domestic Substances List, - Priority Chemical identified under the California Environmental Contaminant Biomonitoring Program, - Included in the European Union candidate list of Substances of Very High Concern in accordance with Article 59 of Regulation (EC) 1907, 2006 on the basis of Article 57(d), Article 57(e), or Article 57(f) for persistent, bioaccumulative and toxic, or very persistent and very bioaccumulative properties, Potential Health Impacts: Bioaccumulation, Endocrine Toxicity, Environmental Persistence, Hepatotoxicity and Digestive System Toxicity, and Reproductive Toxicity, Product count: 198, Information on 10 consumer products that contain Dodecamethylcyclohexasiloxane in the following categories is provided:, • Auto Products, • Personal Care, Methods of Manufacturing: Isolated from the hydrolysis product of dimethyldichlorosilane, Formulations, Preparations: Typically including dodecamethylcyclohexasiloxane (D6) with a general formula of (-Si(CH3)2O-)x in a cyclic configuration, where x is generally less than 8, and more commonly x is 3-7. This formulation is commonly used in cosmetics., U.S. Production: 2023: 5, 500, 000 - <7, 000, 000 lb, 2022: 5, 2021: 7, 000 - <8, 2020: 5, Production volumes for non-confidential chemicals reported under the Inventory Update Rule.[Table#7388], Cyclohexasiloxane, dodecamethyl- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and, or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B, 51FR21438)., Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: Cyclohexasiloxane, 2, 4, 6, 8, 10, 12, 12-dodecamethyl-. National Production Volume: 1, 000 - 10, yr., General Manufacturing Information: Plastics Product Manufacturing, All Other Basic Inorganic Chemical Manufacturing, Other (requires additional information), Paint and Coating Manufacturing, All Other Chemical Product and Preparation Manufacturing, 12-dodecamethyl-: ACTIVE, Cyclomethicone, is a common name for a mixture of cyclic dimethyl siloxanes, Cyclomethicone is a generic name for several cyclic dimethyl polysiloxane compounds ... it refers not only to octamethylcyclotetrasiloxane (D4), but also to cyclotrisiloxane (D3), cyclopentasiloxane (D5), cyclohexasiloxane (D6), and cycloheptasiloxane (D7), i.e. compounds of the general formula (CH3)2n-(O)n-(Si)n where n = 3-7..
Independent reference data for Cyclohexasiloxane (CAS 540-97-6), compiled from public chemistry databases.
| CAS Registry Number | 540-97-6 |
|---|---|
| PubChem CID | 10911 |
| Molecular formula | C12H36O6Si6 |
| IUPAC name | 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane |
| UNII (FDA) | XHK3U310BA |
| Molecular Weight | 444.92 |
|---|---|
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 0 |
| Exact Mass | 444.11274807 |
| Monoisotopic Mass | 444.11274807 |
| Topological Polar Surface Area | 55.4 |
| Heavy Atom Count | 24 |
| Boiling Point | 245 °C |
|---|---|
| Melting Point | -3 °C |
| Flash Point | 91 °C (196 °F) - closed cup |
| Solubility | In water, 0.0051 mg/L at 23 °C |
| Density | 0.9672 g/cu cm at 25 °C |
| Vapor Pressure | 0.0169 mm Hg at 25 °C |
| LogP | log Kow = 8.87 |
| Viscosity | 6.62 cSt |
| Surface Tension | 19.2 mN/m at 20 °C; 18.8 mN/m at 25 °C |
DODECAMETHYLCYCLOHEXASILOXANE; 540-97-6; Cyclohexasiloxane, dodecamethyl-; Cyclomethicone 6; XHK3U310BA; XIAMETER PMX-0246; DTXSID6027183; RefChem:590100; DTXCID507183; 208-762-8; 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane; Cyclohexasiloxane; MFCD00144215; Simethicone Impurity 5; 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane; S08515
| Regulatory & Food Contact | FDA Cumulative Estimated Daily Intake (CEDI): FCS DODECAMETHYLCYCLOHEXASILOXANE (D6) CIR / INCI: Cosmetics ingredient -> Conditioning/Emollient; Moisturizing/Humectant; Other (Specify); Solvent CIR / INCI: Hair conditioning; Solvent; Emollient |
|---|---|
| GHS notification summary | 81.5% (365 / 448) |
| GHS notification summary | 81.5% (365 / 448) |
|---|---|
| Reported hazard statements | H413 (12.9%), H227 |
This chemical does not meet GHS hazard criteria for 81.5% (365 of 448) of all reports.
H413 (12.9%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]
Cyclohexasiloxane · CAS 540-97-6 · C12H36O6Si6. UNII XHK3U310BA. Boiling Point: 245 °C; Melting Point: -3 °C; Flash Point: 91 °C (196 °F) - closed cup.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 环六硅氧烷