Crospovidone (CAS 25249-54-1) — formula C6H9NO, molecular weight 111.14; category pharmaceutical intermediates and APIs.
| CAS Number | 25249-54-1 |
|---|---|
| Molecular Formula | C6H9NO |
| Molecular Weight | 111.14 |
| Melting Point | 13 °C |
| Boiling Point | 96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg |
| LogP | 0.4 |
| Applications | Uses: Used as a monomer in the production of polyvinyl pyrrolidone, also used in the production of other polymers and organic chemicals, [ACGIH], Using Disinfectants or Biocides [Category: Clean], Plastic Composites Manufacturing [Category: Industry], Used to manufacture water-soluble and insoluble forms of polyvinyl pyrrolidone for pharmaceutical and cosmetic industries and to make copolymers with other monomers intended for use in contact with food. ...Used in cast films adherent to glass, metals, plastics., Solvent for resins, co-monomer for polymerization, binder in cosmetic and pharmaceutical preparations., ...About 10-15% of the monomer is used in the pharmaceutical industry for the production of PVP-iodine complex used as a disinfectant. It is also used as a reactive solvent of UV-curable resins for the production of printing inks and paints as paper and textile auxiliaries, and as an additive in the cosmetics industry., ... Precursor and intermediate for process auxiliaries and additives. The main areas of use are the production of polyvinylpyrrolidone and copolymers, the preferred comonomers being vinyl acetate and methyl acrylate., For more Uses (Complete) data for 2-PYRROLIDINONE, 1-ETHENYL- (6 total), please visit the HSDB record page., Use Classification: Cosmetics -> Film forming, Binding, Antistatic, Emulsion stabilizing, Hair fixing, Industry Uses: Monomers, Adhesion, cohesion promoter, Intermediate, Not Known or Reasonably Ascertainable, Consumer Uses: Adhesion, Household Products: Information on 179 consumer products that contain Polyvinylpyrrolidone (PVP) in the following categories is provided:, • Commercial, Institutional, • Inside the Home, • Personal Care, • Pet Care, Methods of Manufacturing: Industrially, NVP is produced by reacting 2-pyrrolidone with acetylene in high-pressure autoclaves at 130-160 °C and pressures of up to 2.6 MPa. Vinylation proceeds in the liquid phase and is catalyzed by 2-pyrrolidone-potassium, which is obtained by dissolving 1-5% potassium hydroxide (the water formed is removed by distillation in vacuo) or potassium in 2-pyrrolidone. To avoid the danger of explosions acetylene-nitrogen mixtures are used instead of acetylene. The crude product obtained by continuous or batch production is purified by vacuum distillation., Formulations, Preparations: A typical commercial product has the following composition: NVP content, minimum 99 weight percent, 2-pyrrolidone, maximum 0.2 weight percent, water, maximum 0.1 weight percent, color index (freshly filled, APHA), 40 maximum, stabilizers: 10 ppm N, N'-bis(1-methylpropyl)-1, 4-benzenediamine or 0.1 weight percent sodium hydroxide., Polyquaternium-11 is a copolymer of vinylpyrrolidone and dimethylamine ethylmethacrylate, partially quaternized with diethyl sulfate....Industry specifications for Polyquaternium-11 allow residual vinylpyrrolidone to a maximum concentration of 1.0%. ...The principal use of Polyquaternium-11 in cosmetic products is in hair care preparations., Polyvinylpyrrolidone, Vinyl Acetate Copolymer (PVP, VA Copolymer) is the copolymer of vinyl pyrrolidone (VP) and vinyl acetate (VA) monomers. The copolymers vary in their ratio of VP to VA and range from 70:30 to 30:70 VP to VA., U.S. Production: 2023: 55, 000, 000 - <70, 000 lb, 2022: 55, 2021: 55, 2020: 55, General Manufacturing Information: Printing Ink Manufacturing, All Other Basic Organic Chemical Manufacturing, Adhesive Manufacturing, All Other Chemical Product and Preparation Manufacturing, 2-Pyrrolidinone, 1-ethenyl-: ACTIVE, PVP, VA Copolymer is used in tablet coating, spray bandages, protective masks, spray or rub-on gloves, plant leaf sprays, shoe polishes, and film production, it is also used as a dye medium in adhesive sticks and in the synthesis of peptides. |
| Category | Pharma Excipients |
Documented applications: Uses: Used as a monomer in the production of polyvinyl pyrrolidone, also used in the production of other polymers and organic chemicals, [ACGIH], Using Disinfectants or Biocides [Category: Clean], Plastic Composites Manufacturing [Category: Industry], Used to manufacture water-soluble and insoluble forms of polyvinyl pyrrolidone for pharmaceutical and cosmetic industries and to make copolymers with other monomers intended for use in contact with food. ...Used in cast films adherent to glass, metals, plastics., Solvent for resins, co-monomer for polymerization, binder in cosmetic and pharmaceutical preparations., ...About 10-15% of the monomer is used in the pharmaceutical industry for the production of PVP-iodine complex used as a disinfectant. It is also used as a reactive solvent of UV-curable resins for the production of printing inks and paints as paper and textile auxiliaries, and as an additive in the cosmetics industry., ... Precursor and intermediate for process auxiliaries and additives. The main areas of use are the production of polyvinylpyrrolidone and copolymers, the preferred comonomers being vinyl acetate and methyl acrylate., For more Uses (Complete) data for 2-PYRROLIDINONE, 1-ETHENYL- (6 total), please visit the HSDB record page., Use Classification: Cosmetics -> Film forming, Binding, Antistatic, Emulsion stabilizing, Hair fixing, Industry Uses: Monomers, Adhesion, cohesion promoter, Intermediate, Not Known or Reasonably Ascertainable, Consumer Uses: Adhesion, Household Products: Information on 179 consumer products that contain Polyvinylpyrrolidone (PVP) in the following categories is provided:, • Commercial, Institutional, • Inside the Home, • Personal Care, • Pet Care, Methods of Manufacturing: Industrially, NVP is produced by reacting 2-pyrrolidone with acetylene in high-pressure autoclaves at 130-160 °C and pressures of up to 2.6 MPa. Vinylation proceeds in the liquid phase and is catalyzed by 2-pyrrolidone-potassium, which is obtained by dissolving 1-5% potassium hydroxide (the water formed is removed by distillation in vacuo) or potassium in 2-pyrrolidone. To avoid the danger of explosions acetylene-nitrogen mixtures are used instead of acetylene. The crude product obtained by continuous or batch production is purified by vacuum distillation., Formulations, Preparations: A typical commercial product has the following composition: NVP content, minimum 99 weight percent, 2-pyrrolidone, maximum 0.2 weight percent, water, maximum 0.1 weight percent, color index (freshly filled, APHA), 40 maximum, stabilizers: 10 ppm N, N'-bis(1-methylpropyl)-1, 4-benzenediamine or 0.1 weight percent sodium hydroxide., Polyquaternium-11 is a copolymer of vinylpyrrolidone and dimethylamine ethylmethacrylate, partially quaternized with diethyl sulfate....Industry specifications for Polyquaternium-11 allow residual vinylpyrrolidone to a maximum concentration of 1.0%. ...The principal use of Polyquaternium-11 in cosmetic products is in hair care preparations., Polyvinylpyrrolidone, Vinyl Acetate Copolymer (PVP, VA Copolymer) is the copolymer of vinyl pyrrolidone (VP) and vinyl acetate (VA) monomers. The copolymers vary in their ratio of VP to VA and range from 70:30 to 30:70 VP to VA., U.S. Production: 2023: 55, 000, 000 - <70, 000 lb, 2022: 55, 2021: 55, 2020: 55, General Manufacturing Information: Printing Ink Manufacturing, All Other Basic Organic Chemical Manufacturing, Adhesive Manufacturing, All Other Chemical Product and Preparation Manufacturing, 2-Pyrrolidinone, 1-ethenyl-: ACTIVE, PVP, VA Copolymer is used in tablet coating, spray bandages, protective masks, spray or rub-on gloves, plant leaf sprays, shoe polishes, and film production, it is also used as a dye medium in adhesive sticks and in the synthesis of peptides..
Crospovidone is a pharmaceutical intermediate or API compound with CAS registry number 25249-54-1 and molecular formula C6H9NO (molecular weight 111.14), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 25249-54-1
Its molecular formula C6H9NO comprises 6 C, 9 H, 1 N, 1 O atoms.
Also known as: Crospovidone
Category: pharmaceutical intermediates and APIs
The CAS registry number of Crospovidone is 25249-54-1.
Molecular formula C6H9NO, molecular weight 111.14.
It is also registered under: Crospovidone.
Recorded applications: Uses: Used as a monomer in the production of polyvinyl pyrrolidone, also used in the production of other polymers and organic chemicals, [ACGIH], Using Disinfectants or Biocides [Category: Clean], Plastic Composites Manufacturing [Category: Industry], Used to manufacture water-soluble and insoluble forms of polyvinyl pyrrolidone for pharmaceutical and cosmetic industries and to make copolymers with other monomers intended for use in contact with food. ...Used in cast films adherent to glass, metals, plastics., Solvent for resins, co-monomer for polymerization, binder in cosmetic and pharmaceutical preparations., ...About 10-15% of the monomer is used in the pharmaceutical industry for the production of PVP-iodine complex used as a disinfectant. It is also used as a reactive solvent of UV-curable resins for the production of printing inks and paints as paper and textile auxiliaries, and as an additive in the cosmetics industry., ... Precursor and intermediate for process auxiliaries and additives. The main areas of use are the production of polyvinylpyrrolidone and copolymers, the preferred comonomers being vinyl acetate and methyl acrylate., For more Uses (Complete) data for 2-PYRROLIDINONE, 1-ETHENYL- (6 total), please visit the HSDB record page., Use Classification: Cosmetics -> Film forming, Binding, Antistatic, Emulsion stabilizing, Hair fixing, Industry Uses: Monomers, Adhesion, cohesion promoter, Intermediate, Not Known or Reasonably Ascertainable, Consumer Uses: Adhesion, Household Products: Information on 179 consumer products that contain Polyvinylpyrrolidone (PVP) in the following categories is provided:, • Commercial, Institutional, • Inside the Home, • Personal Care, • Pet Care, Methods of Manufacturing: Industrially, NVP is produced by reacting 2-pyrrolidone with acetylene in high-pressure autoclaves at 130-160 °C and pressures of up to 2.6 MPa. Vinylation proceeds in the liquid phase and is catalyzed by 2-pyrrolidone-potassium, which is obtained by dissolving 1-5% potassium hydroxide (the water formed is removed by distillation in vacuo) or potassium in 2-pyrrolidone. To avoid the danger of explosions acetylene-nitrogen mixtures are used instead of acetylene. The crude product obtained by continuous or batch production is purified by vacuum distillation., Formulations, Preparations: A typical commercial product has the following composition: NVP content, minimum 99 weight percent, 2-pyrrolidone, maximum 0.2 weight percent, water, maximum 0.1 weight percent, color index (freshly filled, APHA), 40 maximum, stabilizers: 10 ppm N, N'-bis(1-methylpropyl)-1, 4-benzenediamine or 0.1 weight percent sodium hydroxide., Polyquaternium-11 is a copolymer of vinylpyrrolidone and dimethylamine ethylmethacrylate, partially quaternized with diethyl sulfate....Industry specifications for Polyquaternium-11 allow residual vinylpyrrolidone to a maximum concentration of 1.0%. ...The principal use of Polyquaternium-11 in cosmetic products is in hair care preparations., Polyvinylpyrrolidone, Vinyl Acetate Copolymer (PVP, VA Copolymer) is the copolymer of vinyl pyrrolidone (VP) and vinyl acetate (VA) monomers. The copolymers vary in their ratio of VP to VA and range from 70:30 to 30:70 VP to VA., U.S. Production: 2023: 55, 000, 000 - <70, 000 lb, 2022: 55, 2021: 55, 2020: 55, General Manufacturing Information: Printing Ink Manufacturing, All Other Basic Organic Chemical Manufacturing, Adhesive Manufacturing, All Other Chemical Product and Preparation Manufacturing, 2-Pyrrolidinone, 1-ethenyl-: ACTIVE, PVP, VA Copolymer is used in tablet coating, spray bandages, protective masks, spray or rub-on gloves, plant leaf sprays, shoe polishes, and film production, it is also used as a dye medium in adhesive sticks and in the synthesis of peptides..
Category: Pharma Excipients.
Independent reference data for Crospovidone (CAS 25249-54-1), compiled from public chemistry databases.
| CAS Registry Number | 25249-54-1 |
|---|---|
| PubChem CID | 6917 |
| Molecular formula | C6H9NO |
| IUPAC name | 1-ethenylpyrrolidin-2-one |
| UNII (FDA) | 76H9G81541 |
| Molecular Weight | 111.14 |
|---|---|
| XLogP3 | 0.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 1 |
| Exact Mass | 111.068413911 |
| Monoisotopic Mass | 111.068413911 |
| Topological Polar Surface Area | 20.3 |
| Heavy Atom Count | 8 |
| Boiling Point | 96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg |
|---|---|
| Boiling Point | at 1.3kPa: 90-93 °C |
| Boiling Point | 194 °F |
| Melting Point | 13 °C |
| Melting Point | 57 °F |
| Flash Point | 95 °C |
| Flash Point | 100.5 °C (213 °F) open cup |
| Flash Point | 95 °C closed cup |
| Flash Point | 93 °C |
| Flash Point | 199.4 °F |
88-12-0; N-VINYL-2-PYRROLIDONE; 1-Vinyl-2-pyrrolidone; 1-Vinyl-2-pyrrolidinone; Vinylpyrrolidone; 1-ethenylpyrrolidin-2-one; 2-Pyrrolidinone, 1-ethenyl-; Vinylbutyrolactam; Vinylpyrrolidinone; 1-Vinylpyrrolidinone; 1-Ethenyl-2-pyrrolidinone; DTXSID2021440; DTXCID101440; RefChem:1092137; 201-800-4; 1-vinylpyrrolidin-2-one
| Regulatory & Food Contact | FDA Substance added to food: PROCESSING AID, SURFACE-FINISHING AGENT FDA Inventory of Food Contact Substances Listed in 21 CFR: FCS POLYVINYL POLYPYRROLIDONE CIR / INCI: Antistatic; Film forming; Binding; Emulsion stabilizing; Hair fixing |
|---|---|
| GHS notification summary | 0.1% (1 / 963) |
| GHS notification summary | 0.1% (1 / 963) |
|---|---|
| Reported hazard statements | H302, H312, H318, H332, H335, H351, H373, H311 |
H302: Harmful if swallowed [Warning Acute toxicity, oral]
H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
PVP-K30 · CAS 25249-54-1 · C6H9NO. UNII 76H9G81541. Boiling Point: 96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg; Boiling Point: at 1.3kPa: 90-93 °C; Boiling Point: 194 °F.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: Crospovidone