Cortisone

Description

Cortisone · CAS 53-06-5 · C21H28O5. UNII V27W9254FZ. Melting Point: 222 °C; Solubility: 0.28 mg/mL at 25 °C; LogP: 1.47.

Identification

CAS Registry Number	53-06-5
PubChem CID	222786
Molecular formula	C21H28O5
IUPAC name	(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
UNII (FDA)	V27W9254FZ

Computed Descriptors

Molecular Weight	360.4
XLogP3	1.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	360.19367399
Monoisotopic Mass	360.19367399
Topological Polar Surface Area	91.7
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	222 °C
Solubility	0.28 mg/mL at 25 °C
LogP	1.47
LogP	1.64
Collision Cross Section	191.4 Ų [M-H]-
Collision Cross Section	213.5 Ų [M+Na]+
Collision Cross Section	188.4 Ų [M+H]+

Physical description & handling notes

• Solid
• 257.2 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID5022857]
• 180.07 Ų [M-H2O-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
• 188.6 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
• 172.48 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 186.07 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H361 (98%)

Documented Uses

• Pharmaceuticals -> Steroid hormones
• Pharmaceuticals -> Animal Drugs -> Approved in Taiwan
• Breast Feeding; Lactation; Milk, Human; Corticosteroids, Systemic; Glucocorticoids; Anti-Inflammatory Agents
• Cortisone is a known transformation product of Hydrocortisone.
• Substances that reduce or suppress INFLAMMATION.
• Established Pharmacologic Class [EPC] - Corticosteroid

Synonyms

cortisone; 53-06-5; Kendall's compound E; Reichstein's substance FA; Wintersteiner's compound F; 17-Hydroxy-11-dehydrocorticosterone; 11-Dehydro-17-hydroxycorticosterone; Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-; Cortisona; Cortisonum; Kortison; 4-Pregnene-17alpha,21-diol-3,11,20-trione; 17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione; DTXSID5022857; Pregn-4-en-17alpha,21-diol-3,11,20-trione; 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione

Frequently Asked Questions

What are the CAS number and molecular formula of Cortisone?

CAS 53-06-5; molecular formula C21H28O5; molecular weight — g/mol.

What other names is Cortisone known by?

cortisone, 53-06-5, Kendall's compound E, Reichstein's substance FA, Wintersteiner's compound F, 17-Hydroxy-11-dehydrocorticosterone.

Is Cortisone classified as hazardous?

Hazard statements reported: H361.

What are the key physical properties of Cortisone?

Melting Point: 222 °C; Solubility: 0.28 mg/mL at 25 °C; LogP: 1.47; LogP: 1.64.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.