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Cobimetinib

CAS 934660-93-2C21H21F3IN3O2MW 531.3

Cobimetinib (CAS 934660-93-2) — formula C21H21F3IN3O2, molecular weight 531.3; category pharmaceutical intermediates and APIs.

Product Description

Cobimetinib (CAS 934660-93-2) is a chemical raw material in the pharmaceutical intermediates and APIs category. Its molecular formula C21H21F3IN3O2 comprises 21 C, 21 H, 3 F, 1 I, 3 N, 2 O atoms. Its molecular weight is about 531.3. Reported physicochemical data: LogP about 3.9. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.

Product Overview

CAS Number934660-93-2
Molecular FormulaC21H21F3IN3O2
Molecular Weight531.3
LogP3.9
CategoryPharmaceutical Intermediates & APIs

Technical Profile

What this product is

Cobimetinib is a pharmaceutical intermediate or API compound with CAS registry number 934660-93-2 and molecular formula C21H21F3IN3O2 (molecular weight 531.3), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.

Identification

CAS number: 934660-93-2

Its molecular formula C21H21F3IN3O2 comprises 21 C, 21 H, 3 F, 1 I, 3 N, 2 O atoms.

Also known as: Cobimetinib · 考比替尼

Category: pharmaceutical intermediates and APIs

Frequently Asked Questions

What is the CAS number of Cobimetinib?

The CAS registry number of Cobimetinib is 934660-93-2.

What is the molecular formula and molecular weight of Cobimetinib?

Molecular formula C21H21F3IN3O2, molecular weight 531.3.

What other names is Cobimetinib known by?

It is also registered under: Cobimetinib, 考比替尼.

Which category does Cobimetinib belong to?

Category: Pharmaceutical Intermediates & APIs.

Packaging & documentation

Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.

PubChem Public Data

Independent reference data for Cobimetinib (CAS 934660-93-2), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number934660-93-2
PubChem CID16222096
Molecular formulaC21H21F3IN3O2
IUPAC name[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone
UNII (FDA)ER29L26N1X

Computed descriptors

Molecular Weight531.3
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass531.06306
Monoisotopic Mass531.06306
Topological Polar Surface Area64.6
Heavy Atom Count30

Documented uses on record

    Cobimetinib is indicated in combination with [vemurafenib] for the treatment of unresectable or metastatic melanoma with a BRAF V600E or V600K mutation. As a single agent, cobimetinib is also indicated for the treatment of adult patients with histiocytic neoplasms.Cobimetinib is a tyrosine kinase receptor inhibitor that is used in combination with vemurafenib as therapy for selected forms of advanced malignant melanoma. The combination of cobimetinib and vemurafenib is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.

    Synonyms and trade names

    Cobimetinib; 934660-93-2; GDC-0973; XL518; Cotellic; GDC 0973; Xl-518; RG7420; XL 518; RG 7420; ER29L26N1X; CHEBI:90851; DTXSID60239435; 1-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl}-3-[(2S)-piperidin-2-yl]azetidin-3-ol; cobimetinibum; 1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-((2S)-piperidin-2-yl)azetidin-3-ol

    What the public record says

    Cobimetinib · CAS 934660-93-2 · C21H21F3IN3O2. UNII ER29L26N1X.

    Source: PubChem / Wikidata; the batch COA governs where values differ.

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