cloxacillin (CAS 61-72-3) — formula C19H18ClN3O5S, molecular weight 435.9; category pharmaceutical intermediates and APIs.
cloxacillin (CAS 61-72-3) is a chemical raw material in the pharmaceutical intermediates and APIs category. Its molecular formula C19H18ClN3O5S comprises 19 C, 18 H, 1 Cl, 3 N, 5 O, 1 S atoms. Its molecular weight is about 435.9. Reported physicochemical data: LogP about 2.48. As a sourcing and distribution partner we help locate and compare this item across domestic and cross-border channels, arranging samples and batch orders with full COA and compliance files.
| CAS Number | 61-72-3 |
|---|---|
| Molecular Formula | C19H18ClN3O5S |
| Molecular Weight | 435.9 |
| LogP | 2.48 |
| Applications | MEDICATION, Methods of Manufacturing: 6-Aminopenicillanic acid is acylated with 3-(o-chlorophenyl)-5- methyl-4-isoxazolecarboxylic acid and the resulting cloxacillin (acid) is purified by recrystallizations and converted to the sodium salt /Sodium Cloxacillin USP/, NOT RECOMMENDED IN US FOR USE IN FOOD PRODUCING ANIMALS, MORE RECENTLY INTRODUCED SEMISYNTHETIC DERIVATIVES OF PENICILLIN... CLOXACILLIN...SIMILAR IN ACTION TO PARENT COMPD BUT SOME ARE ALSO EFFECTIVE AGAINST...PENICILLINASE PRODUCING STAPHYLOCOCCI. /PENICILLINS/, SAFE TO ASSUME THAT AFTER...RECOMMENDED OR NON-RECOMMENDED USAGE FDA INSISTS TO ZERO TOLERANCE FOR DRUG IN EDIBLE TISSUES OF ANIMALS & POULTRY INCLUDING THEIR BY-PRODUCTS, MILK |
| Category | Pharmaceutical Intermediates & APIs |
Documented applications: MEDICATION, Methods of Manufacturing: 6-Aminopenicillanic acid is acylated with 3-(o-chlorophenyl)-5- methyl-4-isoxazolecarboxylic acid and the resulting cloxacillin (acid) is purified by recrystallizations and converted to the sodium salt /Sodium Cloxacillin USP/, NOT RECOMMENDED IN US FOR USE IN FOOD PRODUCING ANIMALS, MORE RECENTLY INTRODUCED SEMISYNTHETIC DERIVATIVES OF PENICILLIN... CLOXACILLIN...SIMILAR IN ACTION TO PARENT COMPD BUT SOME ARE ALSO EFFECTIVE AGAINST...PENICILLINASE PRODUCING STAPHYLOCOCCI. /PENICILLINS/, SAFE TO ASSUME THAT AFTER...RECOMMENDED OR NON-RECOMMENDED USAGE FDA INSISTS TO ZERO TOLERANCE FOR DRUG IN EDIBLE TISSUES OF ANIMALS & POULTRY INCLUDING THEIR BY-PRODUCTS, MILK.
cloxacillin is a pharmaceutical intermediate or API compound with CAS registry number 61-72-3 and molecular formula C19H18ClN3O5S (molecular weight 435.9), belonging to the pharmaceutical intermediates and APIs segment of chemical raw materials.
CAS number: 61-72-3
Its molecular formula C19H18ClN3O5S comprises 19 C, 18 H, 1 Cl, 3 N, 5 O, 1 S atoms.
Also known as: cloxacillin · 氯唑西林
Category: pharmaceutical intermediates and APIs
The CAS registry number of cloxacillin is 61-72-3.
Molecular formula C19H18ClN3O5S, molecular weight 435.9.
It is also registered under: cloxacillin, 氯唑西林.
Recorded applications: MEDICATION, Methods of Manufacturing: 6-Aminopenicillanic acid is acylated with 3-(o-chlorophenyl)-5- methyl-4-isoxazolecarboxylic acid and the resulting cloxacillin (acid) is purified by recrystallizations and converted to the sodium salt /Sodium Cloxacillin USP/, NOT RECOMMENDED IN US FOR USE IN FOOD PRODUCING ANIMALS, MORE RECENTLY INTRODUCED SEMISYNTHETIC DERIVATIVES OF PENICILLIN... CLOXACILLIN...SIMILAR IN ACTION TO PARENT COMPD BUT SOME ARE ALSO EFFECTIVE AGAINST...PENICILLINASE PRODUCING STAPHYLOCOCCI. /PENICILLINS/, SAFE TO ASSUME THAT AFTER...RECOMMENDED OR NON-RECOMMENDED USAGE FDA INSISTS TO ZERO TOLERANCE FOR DRUG IN EDIBLE TISSUES OF ANIMALS & POULTRY INCLUDING THEIR BY-PRODUCTS, MILK.
Category: Pharmaceutical Intermediates & APIs.
Packaging is agreed per order, from lab-scale packs to bulk, and confirmed with each order rather than fixed on the page. A Certificate of Analysis (COA) ships with every batch and MSDS is available; where the end use carries a regulatory limit (food contact, pharmaceutical or cosmetic), state the standard at enquiry and the grade is set against it.
Independent reference data for cloxacillin (CAS 61-72-3), compiled from public chemistry databases.
| CAS Registry Number | 61-72-3 |
|---|---|
| PubChem CID | 6098 |
| Molecular formula | C19H18ClN3O5S |
| IUPAC name | (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| UNII (FDA) | O6X5QGC2VB |
| Molecular Weight | 435.9 |
|---|---|
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 4 |
| Exact Mass | 435.0655696 |
| Monoisotopic Mass | 435.0655696 |
| Topological Polar Surface Area | 138 |
| Heavy Atom Count | 29 |
| Solubility | 5.32e-02 g/L |
|---|---|
| LogP | 2.48 |
| LogP | LogP = 2.44 |
| LogP | 2.86 |
| Dissociation Constants | 2.78 |
| Collision Cross Section | 200.94 Ų [M-H]- |
cloxacillin; 61-72-3; Cloxacilline; Cloxacillinum; Cloxacilina; Methocillin S; Syntarpen; Clossacillina; Chloroxacillin; O6X5QGC2VB; (3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin; CHEBI:49566; 6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid; cloxacillina; Cloxacillin, Sodium; Sodium, Cloxacillin
| Reported hazard statements | H315 (85.4%), H317 (91.7%), H319 (85.4%), H334 (97.9%), H335 (85.4%) |
|---|
H315 (85.4%): Causes skin irritation [Warning Skin corrosion/irritation]
H317 (91.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]
cloxacillin · CAS 61-72-3 · C19H18ClN3O5S. UNII O6X5QGC2VB. Solubility: 5.32e-02 g/L; LogP: 2.48; LogP: LogP = 2.44.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd.
中文页面: 氯唑西林