Cetirizine DI HCL

Description

Cetirizine DI HCL · CAS 83881-52-1 · C21H27Cl3N2O3. UNII 64O047KTOA.

Identification

CAS Registry Number	83881-52-1
PubChem CID	55182
Molecular formula	C21H27Cl3N2O3
IUPAC name	2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride
UNII (FDA)	64O047KTOA

Computed Descriptors

Molecular Weight	461.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	460.108726
Monoisotopic Mass	460.108726
Topological Polar Surface Area	53
Heavy Atom Count	29
Formal Charge	0
Complexity	443

Physical description & handling notes

• 198.3 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (99.4%), H317 (39.8%), H360 (39.8%)

Documented Uses

• For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria
• Breast Feeding; Lactation; Milk, Human; Antihistamines
• Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
• Increased Histamine Release [PE]; Cell-mediated Immunity [PE]; Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]; Allergens [CS]
• Histamine H1 Receptor Antagonists [MoA]; Histamine-1 Receptor Antagonist [EPC]
• Histamine-1 Receptor Antagonist [EPC]; Histamine H1 Receptor Antagonists [MoA]

Synonyms

Cetirizine dihydrochloride; 83881-52-1; CETIRIZINE HYDROCHLORIDE; 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride; Cetrine; Cetirizine HCl; Formistin; Alleroff; Zerviate; Allergy relief; Zyrtec Allergy; Zyrtec Hives Relief; P 071; P-071; Topcare all day allergy; Children's Zyrtec Allergy

Frequently Asked Questions

What are the CAS number and molecular formula of Cetirizine DI HCL?

CAS 83881-52-1; molecular formula C21H27Cl3N2O3; molecular weight — g/mol.

What other names is Cetirizine DI HCL known by?

Cetirizine dihydrochloride, 83881-52-1, CETIRIZINE HYDROCHLORIDE, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride, Cetrine, Cetirizine HCl.

Is Cetirizine DI HCL classified as hazardous?

Hazard statements reported: H302, H317, H360.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.