头孢唑林

CAS 25953-19-9C14H14N8O4S3MW 454.5

头孢唑林（CAS 25953-19-9）：分子式 C14H14N8O4S3、分子量 454.5。

产品概览

CAS号	25953-19-9
分子式	C14H14N8O4S3
分子量	454.5
熔点	198-200 °C (decomposes)
LogP	-0.58
应用领域	Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effective against anaerobes as ... penicillins.、First-generation cephalosporins、Mesh Heading: anti-bacterial agents、MEDICATION、Use (kg、approx.) in Germany (2009): >10000、exact) in Germany (2009): 10132、Use (kg) in USA (2002): 4740、Consumption (g per capita、approx.) in Germany (2009): 0.122、exact) in Germany (2009): 0.124、Consumption (g per capita) in the USA (2002): 0.0168、Excretion rate: 1、Calculated removal (%): 22、Methods of Manufacturing: 7-AMINOCEPHALOSPORANIC ACID IS CONVERTED TO ITS SODIUM SALT & ACETYLATED WITH 1H-TETRAZOLE-1-ACETYL CHLORIDE & ACETOXY GROUP IS THEN DISPLACED BY REACTION WITH 5-METHYL-1、3、4-THIADIAZOLE-2-THIOL IN BUFFER SOLN. ...IS ISOLATED AS CEFAZOLIN (ACID) & CONVERTED TO SODIUM SALT WITH SODIUM BICARBONATE.、CEFAZOLIN SODIUM SALT、Formulations、Preparations: Trade Name ... Kefzol、Zolicef、From table、Parenteral: For injection: 500 mg (of cefazolin) Ancef、(GlaxoSmithKline)、Cefazolin Sodium for Injection、(American Pharmaceutical Partners)、(Sandoz)、1 g (of cefazolin) Ancef、10 g (of cefazolin) pharmacy bulk package Ancef、20 g (of cefazolin) pharmacy bulk package Cefazolin Sodium for Injection、(American Pharmaceutical Partners). For injection、.for IV infusion: 1 g (of cefazolin) Ancef Piggyback、(Abbott)、Cefazolin Sodium ADD-Vantage ( with 0.04% polysorbate 80)、Cefazolin Sodium for Injection Piggyback、(Sandoz).、Cefazolin sodium、General Manufacturing Information: Semi-synthetic antibiotic derived from 7-aminocephalosporanic acid、... South African patent 6804513 corresponds to US patent 3516997 (1969、1970 to Fujisawa).

应用领域

登记用途：Uses: Vet: Antibacterial ... usually quite active against many gram-positive bacteria ... moderately active against gram-negative bacteria ... relatively susceptible to beta-lactamases ... not as effective against anaerobes as ... penicillins.、First-generation cephalosporins、Mesh Heading: anti-bacterial agents、MEDICATION、Use (kg、approx.) in Germany (2009): >10000、exact) in Germany (2009): 10132、Use (kg) in USA (2002): 4740、Consumption (g per capita、approx.) in Germany (2009): 0.122、exact) in Germany (2009): 0.124、Consumption (g per capita) in the USA (2002): 0.0168、Excretion rate: 1、Calculated removal (%): 22、Methods of Manufacturing: 7-AMINOCEPHALOSPORANIC ACID IS CONVERTED TO ITS SODIUM SALT & ACETYLATED WITH 1H-TETRAZOLE-1-ACETYL CHLORIDE & ACETOXY GROUP IS THEN DISPLACED BY REACTION WITH 5-METHYL-1、3、4-THIADIAZOLE-2-THIOL IN BUFFER SOLN. ...IS ISOLATED AS CEFAZOLIN (ACID) & CONVERTED TO SODIUM SALT WITH SODIUM BICARBONATE.、CEFAZOLIN SODIUM SALT、Formulations、Preparations: Trade Name ... Kefzol、Zolicef、From table、Parenteral: For injection: 500 mg (of cefazolin) Ancef、(GlaxoSmithKline)、Cefazolin Sodium for Injection、(American Pharmaceutical Partners)、(Sandoz)、1 g (of cefazolin) Ancef、10 g (of cefazolin) pharmacy bulk package Ancef、20 g (of cefazolin) pharmacy bulk package Cefazolin Sodium for Injection、(American Pharmaceutical Partners). For injection、.for IV infusion: 1 g (of cefazolin) Ancef Piggyback、(Abbott)、Cefazolin Sodium ADD-Vantage ( with 0.04% polysorbate 80)、Cefazolin Sodium for Injection Piggyback、(Sandoz).、Cefazolin sodium、General Manufacturing Information: Semi-synthetic antibiotic derived from 7-aminocephalosporanic acid、... South African patent 6804513 corresponds to US patent 3516997 (1969、1970 to Fujisawa).。

技术档案

这个产品是什么

头孢唑林是一种化工化合物，登记 CAS 号为 25953-19-9，分子式 C14H14N8O4S3（分子量 454.5）。

识别信息

登记 CAS 号：25953-19-9

其分子式 C14H14N8O4S3 由 14 个碳、14 个氢、8 个氮、4 个氧、3 个硫组成。

别名/同义词：头孢唑林 · Cefazolin

常见问题

头孢唑林的 CAS 号是多少？

头孢唑林的 CAS 登记号为 25953-19-9。

头孢唑林的分子式与分子量是多少？

分子式 C14H14N8O4S3，分子量 454.5。

头孢唑林还有哪些别名？

别名/同义词：头孢唑林、Cefazolin。

头孢唑林的登记用途是什么？

PubChem 公开数据

头孢唑林（CAS 25953-19-9）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

CAS Registry Number	25953-19-9
PubChem CID	33255
Molecular formula	C14H14N8O4S3
IUPAC name	(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
UNII (FDA)	IHS69L0Y4T

计算分子描述符

Molecular Weight	454.5
XLogP3	-0.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	7
Exact Mass	454.03001448
Monoisotopic Mass	454.03001448
Topological Polar Surface Area	235
Heavy Atom Count	29

在册的理化数值

Melting Point	198-200 °C (decomposes)
Solubility	4.87e-01 g/L
LogP	-0.58
LogP	log Kow = -0.58
LogP	-0.24

在册的记载用途

同义词与商品名

cefazolin; 25953-19-9; Cephazolin; Cefazoline; Cephamezine; Cefamezin; Cephazoline; Cephazolidin; Cefazolina; Cefazolinum; Elzogram; DTXSID2022753; IHS69L0Y4T; J01DB04; CHEBI:474053; DTXCID302753

GHS 危害分类

Reported hazard statements	H317 (100%), H334 (100%)

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

公开数据库对它的描述

Cefazolin · CAS 25953-19-9 · C14H14N8O4S3. UNII IHS69L0Y4T. Melting Point: 198-200 °C (decomposes); Solubility: 4.87e-01 g/L; LogP: -0.58.

物理形态与操作说明

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。