Canertinib

CAS 267243-28-7C24H25ClFN5O3MW 485.9

Canertinib (CAS 267243-28-7) — formula C24H25ClFN5O3, molecular weight 485.9.

Product Overview

CAS Number	267243-28-7
Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.9
LogP	3.9

Technical Profile

What this product is

Canertinib is a chemical compound with CAS registry number 267243-28-7 and molecular formula C24H25ClFN5O3 (molecular weight 485.9).

Identification

CAS number: 267243-28-7

Its molecular formula C24H25ClFN5O3 comprises 24 C, 25 H, 1 Cl, 1 F, 5 N, 3 O atoms.

Also known as: Canertinib · 卡纳替尼

Frequently Asked Questions

What is the CAS number of Canertinib?

The CAS registry number of Canertinib is 267243-28-7.

What is the molecular formula and molecular weight of Canertinib?

Molecular formula C24H25ClFN5O3, molecular weight 485.9.

What other names is Canertinib known by?

It is also registered under: Canertinib, 卡纳替尼.

PubChem Public Data

Independent reference data for Canertinib (CAS 267243-28-7), compiled from public chemistry databases.

Registry identifiers across databases

CAS Registry Number	267243-28-7
PubChem CID	156414
Molecular formula	C24H25ClFN5O3
IUPAC name	N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide
UNII (FDA)	C78W1K5ASF

Computed descriptors

Molecular Weight	485.9
XLogP3	3.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	485.1629955
Monoisotopic Mass	485.1629955
Topological Polar Surface Area	88.6
Heavy Atom Count	34

Documented uses on record

Investigated for use/treatment in breast cancer and lung cancer.
CI-1033 effectively inhibits the growth of esophageal squamous cell carcinoma which co-expresses both EGFR and HER2 with the inhibition of phosphorylation of both MAPK and AKT. Some studies suggest that CI-1033 holds significant clinical potential in esophageal cancer.

Synonyms and trade names

Canertinib; 267243-28-7; DTXSID8048943; N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide; C78W1K5ASF; N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; DTXCID1028869; CHEBI:61399; 2-PROPENAMIDE, N-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-(3-(4-MORPHOLINYL)PROPOXY)-6-QUINAZOLINYL)-; canertinibum; RefChem:917970; CI 1033; Canertinib (CI-1033); CI-1033; Canertinib [INN]; Canertinib free base

What the public record says

Canertinib · CAS 267243-28-7 · C24H25ClFN5O3. UNII C78W1K5ASF.

Source: PubChem / Wikidata; the batch COA governs where values differ.