Brinzolamide

Description

Brinzolamide · CAS 138890-62-7 · C12H21N3O5S3. UNII 9451Z89515. Melting Point: 131; Melting Point: 131 °C; Solubility: 7.13e-01 g/L.

Identification

CAS Registry Number	138890-62-7
PubChem CID	68844
Molecular formula	C12H21N3O5S3
IUPAC name	(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
UNII (FDA)	9451Z89515

Computed Descriptors

Molecular Weight	383.5
XLogP3	-0.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	383.06433430
Monoisotopic Mass	383.06433430
Topological Polar Surface Area	164
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	131
Melting Point	131 °C
Solubility	7.13e-01 g/L
LogP	-1.8

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• Brinzolamide, either as a standalone agent or in combination with brimonidine, is approved by the FDA for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Brinzolamide is also approved in Europe to be used in combination with timolol to treat the same conditions.
• Breast Feeding; Lactation; Milk, Human; Antiglaucoma Agents; Carbonic Anhydrase Inhibitors
• A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
• Established Pharmacologic Class [EPC] - Carbonic Anhydrase Inhibitor

Synonyms

Brinzolamide; 138890-62-7; Azopt; AL-4862; Brinzolamida; AL 4862; DTXSID6045531; NSC-760050; CHEBI:3176; (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide 1,1-dioxide; DTXCID4025531; AZARGA COMPONENT BRINZOLAMIDE; 9451Z89515; SIMBRINZA COMPONENT BRINZOLAMIDE; (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide; brinzolamidum

Frequently Asked Questions

What are the CAS number and molecular formula of Brinzolamide?

CAS 138890-62-7; molecular formula C12H21N3O5S3; molecular weight — g/mol.

What other names is Brinzolamide known by?

Brinzolamide, 138890-62-7, Azopt, AL-4862, Brinzolamida, AL 4862.

Is Brinzolamide classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Brinzolamide?

Melting Point: 131; Melting Point: 131 °C; Solubility: 7.13e-01 g/L; LogP: -1.8.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.