巴瑞克替尼

巴瑞克替尼（CAS 1187594-09-7）的独立参考数据，整理自公开化学数据库。

各数据库的登记标识

计算分子描述符

在册的理化数值

在册的记载用途

Baricitinib is a disease-modifying antirheumatic drug (DMARD) indicated for rheumatoid arthritis when conventional DMARDs prove inadequate.Baricitinib is an orally available small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis, severe alopecia areata, and, in combination with remdesivir, severe COVID-19 in hospitalized patients requiring supplementary oxygen. Baricitinib is associated with transient and usually mild elevations in serum aminotransferase levels during therapy but has yet to be linked to cases of clinically apparent acute liver injury.

同义词与商品名

Baricitinib; 1187594-09-7; olumiant; LY3009104; INCB028050; INCB 028050; INCB-028050; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; LY-3009104; LY 3009104; ISP4442I3Y; DTXCID5074719; CHEBI:95341; DTXSID30152228; L04AA37; 3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)-

GHS 危害分类

Reported hazard statements	H302 (50%), H335 (16.7%), H360 (66.7%), H372 (16.7%), H373 (66.7%), H411 (66.7%)

H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]

H335 (16.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

公开数据库对它的描述

Baricitinib · CAS 1187594-09-7 · C16H17N7O2S. UNII ISP4442I3Y. Boiling Point: 707.2.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。