阿佐塞米

Description

Azosemide · CAS 27589-33-9 · C12H11ClN6O2S2. UNII MR40VT1L8Z. Melting Point: 219.5 °C.

Identification

CAS Registry Number	27589-33-9
PubChem CID	2273
Molecular formula	C12H11ClN6O2S2
IUPAC name	2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
UNII (FDA)	MR40VT1L8Z

Computed Descriptors

Molecular Weight	370.8
XLogP3	1.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	370.0073437
Monoisotopic Mass	370.0073437
Topological Polar Surface Area	163
Heavy Atom Count	23
Formal Charge	0

Physical & Chemical Properties

Melting Point	219.5 °C

Physical description & handling notes

• Solid
• Diuretic affects upon oral administration match those of furosemide. However, upon intravenous administration azosemide displays 5.5 to 8 times greater effect.

Documented Uses

• Agents that promote the excretion of urine through their effects on kidney function.
• Peak plasma concentrations are achieved in 3-4 hours when azosemide is administered to healthy humans in a fasting state. There is an absorption lag time of approximately 1 hour. Oral bioavailability estimated to be 20.4%
• Total body clearance 112ml/min. Renal clearance 41.6ml/min. Actively secreted in the renal proximal tubule of humans. This may or may not involve a nonspecific organic acid secretory pathway. There is thus a potential for disease states and other organic acids such as NSAIDs which affect the organic acid transport pathway to affect the efficacy of azosemide.
• Poor affinity for human tissue. Small apparent post-pseudodistribution Vd of 0.262 l/kg.
• > 95% 4% protein binding to 4% human serum albumin at azosemide concentrations of 10-100ug/ml, using equilibrium dialysis.
• Considerable first pass metabolism which makes parentral administration more effective than oral administration. Eleven metabolites of azosemide were found in rats, but only azosemide and its glucuronide were detected in humans.

Synonyms

azosemide; 27589-33-9; Azosemid; Diart; Azosemida; Azosemidum; Luret; DTXSID7046910; MR40VT1L8Z; 2-Chloro-5-(1H-tetrazol-5-yl)-N(sup 4)-2-thenylsulfanilamide; Benzenesulfonamide, 2-chloro-5-(1H-tetrazol-5-yl)-4-((2-thienylmethyl)amino)-; 5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole; DTXCID5026910; CHEBI:31248; 2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzene-1-sulfonamide; 2-chloro-5-(2H-1,2,3,4-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzene-1-sulfonamide

Frequently Asked Questions

What are the CAS number and molecular formula of Azosemide?

CAS 27589-33-9; molecular formula C12H11ClN6O2S2; molecular weight — g/mol.

What other names is Azosemide known by?

azosemide, 27589-33-9, Azosemid, Diart, Azosemida, Azosemidum.

What are the key physical properties of Azosemide?

Melting Point: 219.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.