Azilsartan

Description

Azilsartan · CAS 147403-03-0 · C25H20N4O5. UNII F9NUX55P23. Melting Point: 212-214 °C; LogP: log Kow = 0.90.

Identification

CAS Registry Number	147403-03-0
PubChem CID	135415867
Molecular formula	C25H20N4O5
IUPAC name	2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
UNII (FDA)	F9NUX55P23

Computed Descriptors

Molecular Weight	456.4
XLogP3	4.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	456.14336975
Monoisotopic Mass	456.14336975
Topological Polar Surface Area	115
Heavy Atom Count	34
Formal Charge	0

Physical & Chemical Properties

Melting Point	212-214 °C
LogP	log Kow = 0.90

Physical description & handling notes

• Colorless prisms from ethanol
• Stable under recommended storage conditions.
• Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx).
• pKa at 0.1 N NaOH (26 eg C): 6.1
• Crystals from ethanol /Azilsartan medoxomil/
• Crystals; mp 196 °C (decomposes). Freely soluble in methanol. Practically insolluble in water /Azilsartan kamedoxomil/

GHS Hazard Classification

Reported hazard statements	H360 (25%), H361 (75%), H362 (25%), H372 (25%)

Documented Uses

• Preparation: T. Naka, Y. Inada, European Patent Office patent 0520423; eidem, United States of America patent 5243054 (1992, 1993 both to Takeda).
• United States Food and Drug Administration–Approved Indications
• Azilsartan is an angiotensin II receptor blocker (ARB) used in the therapy of hypertension. It is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Blockers
• Angiotensin II Receptor Antagonists
• Edarbi is an angiotensin II receptor blocker (ARB) indicated for the treatment of hypertension to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including the class to which this drug principally belongs. /Included in US product label/

Synonyms

Azilsartan; 147403-03-0; TAK-536; TAK 536; F9NUX55P23; 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid; CHEBI:68850; DTXSID70163712; 2-ethoxy-3-((4-(2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl)phenyl)methyl)benzimidazole-4-carboxylic acid; RefChem:54400; DTXCID1086203; Azilsartan [USAN]; AZILSARTAN [INN]; MFCD20278186; C25H20N4O5; CHEMBL57242

Frequently Asked Questions

What are the CAS number and molecular formula of Azilsartan?

CAS 147403-03-0; molecular formula C25H20N4O5; molecular weight — g/mol.

What other names is Azilsartan known by?

Azilsartan, 147403-03-0, TAK-536, TAK 536, F9NUX55P23, 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid.

Is Azilsartan classified as hazardous?

Hazard statements reported: H360, H361, H362, H372.

What are the key physical properties of Azilsartan?

Melting Point: 212-214 °C; LogP: log Kow = 0.90.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.